brandonscopes

[Bryan Johnson @bryan_johnson]

Cancer runs in my family and about 5-10% of cancer is inherited. So I did a blood test that looked at 71 genes for inherited cancer risk.

All came back negative. I feel lucky.

You can sleep, exercise and eat right for decades, and one late cancer can do you in. Cancer is the second leading cause of death in the US, the first for anyone under 85. More than 1 in 3 of us will be diagnosed. A cancer death costs nearly 15 years of life, on average.

You want to catch cancer early. Breast cancer has a 5 year survival near 100% but caught late, survival drops to about 34%. Colon cancer: 91% versus 16%.

A genetic risk panel won't tell you if you have cancer. It tells you whether you were born holding a bad card, so you can watch the right things, sooner.

So I ran a combined DNA + RNA Panel covering 71 genes tied to inherited cancer risk, with RNA analysis on most. They cover the big hereditary pathways. DNA repair (BRCA1, BRCA2, ATM). Lynch syndrome (MLH1, MSH2). The classic tumor suppressors (TP53, APC, PTEN). The endocrine genes (RET, VHL, MEN1).

DNA shows the spelling of a gene. RNA shows what the cell actually builds from it. Up to 1 in 4 cancer-gene variants are predicted to disrupt splicing, the RNA edit that makes a working protein, and DNA alone often can't tell whether it matters, so it gets flagged "uncertain." Reading the RNA settles a lot of those, and catches broken variants DNA-only tests miss.

My result came back with no pathogenic variants in any of the tested genes, so it looks like I was born lucky.

This doesn't mean it clears cancer risk and it says nothing about the 90 to 95% of cancers that aren't inherited or influenced over a lifetime from age, environment, and luck.

Cancer surveillance is among the least glamorous parts of a longevity stack. It's also the most underrated.

The name of this test is Invitae Multi-Cancer Panel.

[Bryan Johnson @bryan_johnson]

Some of us will live forever.

And if you’re reading this, that may or may not be you.

I am so bullish on this that I just renamed my company to Immortals.

Below:
+ why I think this
+ early signs of success
+ how to increase your odds

Yes, I know this sounds crazy.

Immortality has been an ambition for humanity since the beginning of recorded history.

The immortality I’m referring to is specific: increases in life expectancy will outpace the rate of aging. Meaning, we will no longer, by default, expect to die of natural causes.

I believe this for three reasons.

#1: Immortality already exists

Biology can reverse some features of aging, and in a handful of organisms escape it almost entirely. For example, a sperm and an egg from two people in their 30s carry the legacy of bodies that have aged for decades (the egg in particular has been arrested inside the mother since before she herself was born), yet they combine to produce an embryo that resets the aging clock to zero.

The immortal jellyfish goes further and resets itself within one lifetime, reverting its adult cells to an earlier stage through transdifferentiation and starting its life cycle again. And in the lab, scientists have begun doing this deliberately, making induced pluripotent stem cells (iPSCs) from mature adult cells such as skin fibroblasts, and using partial cellular reprogramming to turn the clock back in the tissues of living animals.

#2: AI offers new potentials

Biology is a hard problem. For most of history that complexity was beyond native human capacity. AI was made for this complexity. The clearest demonstration so far is protein folding. Predicting the three-dimensional shape a protein folds was an unsolved problem for roughly fifty years, and it mattered because a protein's shape determines what it does in the body.

DeepMind's AlphaFold2 effectively solved it in 2020, reaching a median accuracy of 92.4 out of 100, a level long thought to require the slow, painstaking work of crystallizing a protein and solving its structure by X-ray crystallography. It then released predicted structures for over 200 million proteins, nearly the entire catalogued protein universe, in a fraction of the time anyone expected.

#3: Early signs are encouraging

These aspirations are not imaginative. With the current tools in biotech Sid Sijbrandij, the co-founder of GitLab, was diagnosed with an aggressive bone cancer, osteosarcoma in his vertebrae. He treated his own disease like an engineering problem, he used AI to help direct several experimental, personalized therapies in parallel and drove the cancer into remission after standard medicine had given up. Around the same time, an Australian named Paul Conyngham, with no medical or biology background, did something similar for his dog. He used AI to help design a personalized mRNA vaccine targeting the specific mutations in his dog's tumor, and after it was given alongside another immunotherapy and within a few months the main tumor had shrunk by roughly three-quarters.

How to increase your odds…

I. Don’t die in the meantime

We don’t know when these longevity therapies will become available. Your goal is to be around when they come out. Buy yourself as much time as possible by looking after your body to the best of our scientific knowledge. Good diet, sleep, exercise will get you 80% of the results.

II. Find your achilles

Longevity therapies will likely be outcome specific. Individual specific drugs/therapies that target specific things like…

> prevent and remove arterial plaque
> prevent and reverse neurodegeneration
> specifically target and eliminate cancers, or pre cancerous legions
> prevent frailty and muscle loss, and regain muscle mass, strength and, bone density
> reverse skin aging
> rejuvenate eye health
> restore lost hearing
> etc

We don’t know what therapies will be available first. Your goal is to find what your body is struggling with most and keep that problem at-bay until a therapy is available that can fully cure or reverse it.

For example, do you struggle with cholesterol? Blood glucose control? Cognitive decline? Find your achilles heel and reduce your risk systematically.

III. Invest in the future

There are three macro trends happening on planet earth right now, and the people who bet on these areas have the highest risk + reward.

> AI
> Immortality
> Energy

As we know, power comes in many forms: money, social, political, health, etc. Those that can collect power in these fields will have the greatest chance of positioning themselves in the Immortal future.

With time, Immortal therapies will become broadly available.

If you’re reading this: don’t waste your chances by burning down your life points on a yolo-like mentality. Grind culture, addiction, social media pollution, fast food, porn, alcohol, these are all corporations turning your life into their profit. This is the Die Economy.

My company Immortals has the sole objective of turning your time, attention, and life into more healthy, functional, and prosperous minutes, days, and years. The Don’t Die Economy.

Good luck.

[Teddy - PolyBackTest.com @Bitcoin_Teddy]

Pewdiepie reveals how to break free from the algorithm

“A lot of this is going to sound crazy but you’ve gotta hear me out, it’s a step by step process. I’m not saying you should do all of it but you should try some of it”

“Step 1 is creating friction. I put all social media and attention hungry apps in a second profile and I can’t understate how much this changed my life. Those 5-6 seconds it takes to switch profiles stops me every time and makes me think, is this what I want to be doing?”

“The second thing I did was self hosting. The effect that had on me is I’m not the product anymore. The things I use are mine and because they’re not free, I’m not paying with my privacy. I think the main difference is ads and news don’t reach me”

“Next thing I did was disable Shorts, I like YouTube but I hate how Shorts is everywhere I can’t escape it”

“Then I unfollowed everyone. You don’t have to do this, this is definitely a me thing, I just got really fed up”

“Next, get a DNS blocker. You can remove ads completely, most of it won’t even reach your device”

“I think you owe it to yourself to take some time today and start building your tech fence”

“These tech companies don’t care about you, so you’ve got to care about yourself. The cheat code is building some friction and filtering out the noise, that’s your defence and your cure”

[Gary Brecka @thegarybrecka]

🚨 Your home environment affects your health as much as your diet.

Five swaps worth making this week.

1️⃣ Replace plastic food storage with glass containers
2️⃣ Switch synthetic candles for beeswax or soy with essential oils
3️⃣ Open windows for 10 minutes daily. Indoor air is 2 to 5x more polluted than outdoor air.
4️⃣ Replace synthetic air freshener with an essential oil diffuser
5️⃣ Add a houseplant. Snake plants and pothos filter indoor air naturally.

✅ A non-toxic home is not built overnight.

One swap at a time. Start today. 👇🏻

[brandonscopes @brandonscopes]

@EricCrossMLB Good time to sell👀
Just offered him for Schwellenbach in one deal and Kade Anderson in another

[Dan Go @CoachDanGo]

If I had $100,000 to invest in my health, I'd buy these:

- Sauna
- Hot tub
- Home gym
- Air purifier
- Meal prep
- Cold plunge
- Health coach
- Water flosser
- Standing desk
- Under desk treadmill
- Functional blood work
- Red light therapy lamp
- Incandescent light bulbs
- Reverse osmosis water filter
- Great mattress and bedding
- Membership at the best gym in the area

What about you?

[Gary Brecka @thegarybrecka]

I have tested a lot of expensive interventions over the years.

The ones that moved my biomarkers the most: sleep consistency, Zone 2 training, time restricted eating, morning sunlight, and strength training.

Combined cost: nearly zero. The basics are not boring. They are underestimated.

[Thomas Nestico @TJStats]

My Top 100 Prospects

[Prospect Tilt @Prospect_Tilt]

Top 100 Minor League Baseball Prospect Rankings - May 2026 ⚾️ 📈📉

[Ross Jensen @rossjensen]

My personal top 100 prospects 🤡

*non-debuted

[Dan Go @CoachDanGo]

The fastest way to shrink visceral fat (backed by science):

[Gary Brecka @thegarybrecka]

Microplastics have been found in human blood, breast milk, lung tissue, and the placenta.

We are ingesting and inhaling plastic particles every single day from food packaging, synthetic clothing, plastic bottles, and indoor air.

Here are practical ways to reduce your exposure starting this week:
1. Drink from glass or stainless steel instead of plastic.
2. Avoid heating food in plastic containers.
3. Choose natural fiber clothing like cotton, wool, and linen when possible.
4. Filter your tap water with a quality carbon or reverse osmosis filter.
5. Buy dry goods like grains and nuts in bulk using your own glass jars.

You cannot eliminate all exposure. But you can meaningfully reduce it with simple swaps.

[Gary Brecka @thegarybrecka]

One of the most powerful things you can add to your diet this weekend costs almost nothing.

Fermented foods.

Kimchi, sauerkraut, plain kefir, plain Greek yogurt, miso, and kombucha are all rich in live bacteria that support gut microbiome diversity.

Your gut microbiome influences your immune function, your mood, your metabolism, and your cognitive clarity.

One serving of fermented food daily is one of the simplest and most evidence-backed investments you can make in your long-term health.

Start today.

[Gary Brecka @thegarybrecka]

Most conventional cleaning products contain compounds that disrupt hormones, irritate the respiratory system, and accumulate in your body over time.

The good news is the alternatives work just as well and cost less.

Here is what to replace them with:
- All-purpose cleaner: white vinegar diluted with water and a few drops of tea tree oil.
- Glass cleaner: diluted white vinegar with a splash of rubbing alcohol.
- Scrubbing paste: baking soda mixed with a little castile soap.
- Laundry: fragrance-free detergent without optical brighteners or synthetic scents.
- Air freshener: open a window, diffuse essential oils, or simmer lemon and herbs on the stove.

A clean home does not require toxic chemicals.

[Dan Go @CoachDanGo]

Best investments I've made in my health

· Air fryer
· Lab work
· Pedometer
· DEXA scans
· Health coach
· Standing desk
· Under desk treadmill
· Bluelight blockers
· Blackout shades
· Ninja Creami
· Home gym
· Meal prep

What about you?

[brandonscopes @brandonscopes]

@rossjensen @StatlineScout For triple A guys knocking on the door… Who do you like most between Arroyo, Luis Lara, Pedro Ramirez and Cole Carrigg

[Bryan Johnson @bryan_johnson]

This is it.
Everything learned spending millions on longevity.

From: Your Immortal Unc and Auntie.
To: Our Immortal nieces and nephews.

0. Sleep is the world's most powerful drug.
1. Be in your bed for 8 hours
2. Same bedtime every night, any time before midnight
3. Don’t eat right before bed
4. Calm foods for dinner
5. No screens 1 hour before bed
6. Avoid added sugar (be aware it’s in everything)
7. Avoid all things in an American convenience store
8. Avoid fried foods
9. Shoes off at the door
10. Eat whole foods, particularly veggies fruits nuts legumes berries
11. Walk a little after meals or air squats
12. Get your heart rate high routinely
13. Lift heavy things
14. Stretch daily
15. Water pik, floss, brush, tongue scrape, morning and night
16. Make an effort to drink water
17. Get sunlight when you wake up (UV is low)
18. Protect skin in midday sun
19. Stand up straight
20. See at least one friend once a week
21. Avoid plastic where you can (in all things)
22. Circulate air in rooms
23. When stressed, breathe, learn to calm your body
24. Go to the dentist
25. Avoid sitting for long times
26. Protect your hearing, the world is too loud
27. Alcohol is bad for you
28. Finish coffee before noon
29. Avoid bright lights after sunset
30. If obese, look into a GLP
31. Sleep in a cold room
32. Texting while driving is dangerous
33. Turn off all notifications
34. Limit social media use
35. Don’t smoke anything
36. If you struggle to sleep, read a physical book before bed
37. 1 hour before bed have a calm wind down routine: bath, read, light walk, listen to music
38. The body is a clock and loves routine. Have a daily morning and evening schedule.
39. Avoid long distance travel where you can
40. Baby steps first: incorporate new things slowly
41. Do less… most things don’t work.

Bonus points if you get your blood checked.

Start here, it will change your life.

[WarrantWhisperer @pizdets17]

thinking of transferring all my TD stuff (rrsp, tfsa, direct investing, checking account, credit card) to Wealthsimple. Thoughts?

[Bryan Johnson @bryan_johnson]

🚨 I HAVE NO MICROPLASTICS IN MY BALLS 🚨

This should not be possible.

Studies show that 100% of men have microplastics in their semen. I am the first human ever to show a complete reduction to zero.

This may be a world-first breakthrough in fertility research.

I had 165 microplastic particles in my semen just 18 months ago. Now, I have zero.

Five published studies have measured microplastics in human semen. Two found them in 100% of men. The other three found then in 44 to 76% of men tested, but those used methods that miss the smallest particles and the clear ones. Corrected for that, the real rate is likely 100%. Almost every man alive has plastic in his semen right now. The same applies to testicular tissue, testing 100% positive for microplastics.

Microplastics hurt sperm.

Human studies show the impact of various types of plastic, associated chemicals, and other toxins on male fertility:

+ 60% fewer normal shaped sperm (from PFAS)
+ 5x higher odds of low sperm count (from PTFE)
+ 10% lower sperm concentration (from PTFE)
+ 15% lower swimming ability (from PTFE)
+ 41% lower swimming ability (from PET)
+ 12% lower sperm swimming ability (from BPA)
+ 3x higher odds of low sperm count (from Phthalates)
+ 2x higher odds of poor swimming (from Phthalates)

The effects compound: each extra type of plastic drops sperm swimming ability by about 21%.

This matters even if you’re NOT trying to get pregnant.

Sperm count is one of the cleanest biomarkers of overall health we have. And microplastics don't stop at the testes.

The same particles are showing up everywhere we look. Studies show 4.5x higher rate of heart attack, stroke, and death in people with microplastics in their arterial plaque vs. those without. Microplastics were also found in 100% of human placentas tested.

100% of post-mortem human brains tested positive for microplastics. Brain concentrations rose ~50% between 2016 and 2024, and now sit at roughly 11x the levels found in the liver or kidney.

Where do these come from?
+ PTFE, commonly in non-stick pans
+ PET, water bottles
+ Phthalates, makes plastic soft and bendy
+ BPA, can linings
+ PFAS, stain-resistant fabrics & food packaging

Inside the body, plastic causes a kind of cellular rust. It triggers inflammation in the testicles, kills the cells that make sperm and drops testosterone. It's been confirmed across 39 animal and cell studies, then in human data.

MY PROTOCOL:

Note, what I did is n=1, not a controlled trial, I cannot prove cause.

1. Sauna (dry). My toxin blood panel confirms sauna clears plastic related chemicals: BPA, phthalates, PFAS, flame retardants, pesticides. The plastic particles themselves are too big to sweat out directly. Heat may activate other clearance routes: bile flow through the liver, the cell's internal cleanup system, and the gut barrier. Humans have almost no enzymes that can break plastic apart, so the body has to physically push it out.

2. Reverse osmosis water filter. Drinking water is likely a major source of microplastic getting into your body. A reverse osmosis filter pushes water through a very tight membrane and strains the particles out. I filter everything I drink.

3. Trying to rid my environment of the big plastic items: cutting boards, cups, plates, food storage containers, non-stick pans, cling wrap, tea bags, water bottles, kitchen utensils, kettles, and synthetic clothing. Note, as hard as I try, I'm always finding new plastic things in my life. This can be all-consuming thing so try to just knock out the big ones.

I did all three interventions at the same time. I cannot say which one did the most work. What I can say is this: going from 165 to zero in 18 months is possible.

Results:
Nov 2024: 165 particles/mL
Jul 2025: 20 particles/mL
Apr 2026: 0 particles/mL

The 18 month window also captures roughly 7 full spermatogenesis cycles.

[Gary Brecka @thegarybrecka]

How you sit is slowly deforming your body.

Most people spend 8 to 10 hours a day in a position that rounds the lower back, juts the head forward, and internally rotates the shoulders.

Over years this becomes your resting structure. Chronic pain follows.

Three things you can do right now...

Sit at the edge of your chair with your pelvis slightly tilted forward. This naturally restores your lumbar curve.

Bring your screen to eye level so your head is not drooping forward.

Set a timer and stand every 50 minutes.

You cannot undo years of poor posture in a day. But you can stop adding to the damage starting now.