bruce.moran

Genomics/transcriptomics for clinical/diagnostic and translational/research in cancer. Mostly a retweet repo of papers/tools. Fan of reproducibility.

[Joaquin Mateo @quimmateo]

@myESMO Recommendations for clinical reporting of genomics - now published in @Annals_Oncology. We're aiming to advance rational, evidence-based use of genomics in patient care and harmonize biomarker interpretation in cancer treatment
https://t.co/GohY3dWkQB

[Luciano Martelotto 🛠🧬💻🇦🇺 @LGMartelotto]

Here’s the newest and final version:

𝘀𝗻𝗣𝗔𝗧𝗛𝗢-𝘀𝗲𝗾: unlocking the pathology archives

A method/protocol that works very well, has been widely accepted and embraced by scientists globally, yet not as much by peer-reviewed journals. https://t.co/VISRUEtrtO

[bruce.moran @bruler0111]

@yokofakun Vespula vulgaris, common wasp most likely

[bruce.moran @bruler0111]

@AedinCulhane Agree 100%, would be interested to see data to support 500 vs. 50 gene panels in terms of cost + scaling. Also entirely agree that making clinically generated data accessible to research community is necessary.

[HSE Ireland @HSELive]

Today, we launch the National Strategy for Accelerating Genetic and Genomic Medicine in Ireland which outlines the approach for developing a patient and family centred #genetic and #genomic service.

https://t.co/IarvE2S6mH

[bruce.moran @bruler0111]

@nilshomer You can't know everything. Draw mental boundaries based on your interests. Use new projects to redraw boundaries by learning something you think will be useful if time permits (IMO it always should).

[Amin Nassar, MD @AminNassarMD]

📢 📢 📢 📢 📢 📢 📢 📢
1/ Psyched to share our latest in @Cancer_Cell. “Ancestry-driven recalibration of tumor mutational burden and disparate clinical outcomes in response to immune checkpoint inhibitors”.
https://t.co/kKx2sauRer
Accompanying highlight:https://t.co/nQIOzRNPHe

[bruce.moran @bruler0111]

@tangming2005 'while read'

[Jason Sheltzer @JSheltzer]

Out now in @genomeresearch - our comprehensive analysis of the effects of aneuploidy on protein expression. Changes in gene dosage trigger complex compensatory mechanisms that are conserved from yeast to cancer! Great work led by @DrKlaske.

https://t.co/D3G6GlNIhA

[Elaine Kenny @elaneyk1]

So disappointing, yet so very very unexpected. I'm sure there were excellent candidates, why did they not take the job.....

https://t.co/5EvAa4tJta

[Nils Homer @nilshomer]

$ git log --oneline
47972a3 feature: some awesome complex idea
a12a560 first attempt failed, try again
72dbea7 fixed silly typo
4e048f6 fixed
3f5c3b2 fix
59f3d56 fix
dd3da66 f
f1a8ca6 f
8af6c93 ...
3c72dae fuck

[Genome Biology @GenomeBiology]

recount3, from @chrisnwilks. @KasperDHansen, @BenLangmead & co, is a resource of 750,000 mouse and human RNA-seq datasets uniformly processed with the same pipeline. It allows rapid queries across the whole dataset, eg cross-species or cross-study https://t.co/exV5YP1ugr

[Aɴᴛᴏɴɪᴏ Pᴀssᴀʀᴏ @APassaroMD]

🆕@CD_AACR
Functional STK11 mutations is associated with resistance to ICIs in #lungcancer & is reversed by STAT3 knockdown 🌟 #LCSM
https://t.co/vKnWE5toDW

[ClinGen @ClinGenResource]

Announcing the @ClinGenResource Criteria Specification Registry https://t.co/5ot7AITS3X, a database for the management of the Criteria Specifications of @TheACMG evidence codes for variant classification from ClinGen Variant Curation Expert Panels #variantclassification

[GA4GH @GA4GH]

🎉200+ authors came together to deliver the latest issue of @cellgenomics, featuring GA4GH-enabled interop. These papers represent years of tireless effort from a truly global community; we are deeply grateful to each of you. https://t.co/QQwLNV1Vmh

[Nicolas Robine @notSoJunkDNA]

Advancing NGS quality control to enable measurement of actionable mutations in circulating tumor DNA
https://t.co/sziuXg9Olg

[Britt Adamson @bsadamson]

Our work developing Repair-seq, a platform for studying #DNArepair processes, and its application to double-strand breaks is out today @CellCellPress. Alongside, we release https://t.co/7aIPds1XEl, a portal for exploring many, many DNA repair phenotypes! https://t.co/6IizvfCdt3

[Sohrab Shah @SohrabShah]

1/ What are the challenges ahead for multi-modal data integration to improve precision oncology? In this @NatureRevCancer perspective we outline how we might leverage diagnostic cancer data as a substrate for next generation integrative biomarkers. https://t.co/Qpfjwb7GYr

[Olivier Elemento @ElementoLab]

Next-generation immunotherapy: what's next after anti-PD-1/PD-L1 and anti-CTLA4, how to increase the chance of success of novel immuno-oncology strategies in the clinic, and moving towards personalized immuno-medicine. A great review by @merghout and team! https://t.co/LPcJ4jfUsI

[Royal College of Physicians of Ireland @RCPI_news]

Clinical challenges in Genomic Medicine for Cancer Care | 15 Oct

Register now for this free webinar⬇️
https://t.co/OtzUkS1qXU

#GCchat #genetictesting #genetics #genomics