Genome Stability Lab

Understanding and exploiting genome stability & DNA repair mechanisms, ubiquitin/UBLs, cellular micromotors, bioengineering (University of Manchester)

[Alice Ting @aliceyting]

APEX peroxidase is a versatile tool for proximity labeling and electron microscopy (EM) but its requirement for toxic H2O2 is a liability. We now report LaccID, a multicopper oxidase evolved from an ancestral fungal laccase that oxidizes aromatic substrates using non-toxic O2 instead of H2O2. We use LaccID for EM imaging of cultured cells and fly brains, and for proteomic mapping of the changing surface composition of T cells that engage with tumor cells via antigen-specific T cell receptors.

[Itai Yanai @ItaiYanai]

If you think the next big idea in your field will come from inside the field, you're probably wrong.

[Manchester Cancer Research Centre @MCRCnews]

Closing soon - ACED Non-Clinical PhD Studentship. 🚨

💰Fully-funded for 4 years
👩‍🔬Learn from leading cancer researchers
🏥 Rotate your training across various ACED Centres

📅 Deadline: Monday 4 November
🔗 Apply: https://t.co/8bDPzpOg80

[Manchester Cancer Research Centre @MCRCnews]

Applications are open for our Clinical & Non-Clinical PhD projects!

🧬 Access state-of-the art facilities
🌍 Learn from world-leading academics
🐝 Study in the buzzing city of Manchester

📆 Deadline: 15th November

Explore our current projects: https://t.co/FulB48uFcZ

[Grant Stewart @GS_Lab_Bham]

Happy to see our collaborative paper with Cyrus Vaziri’s lab demonstrating that RNF168 is recruited to damaged replication forks via a degenerative PIP box and its MIU1 ubiquitin binding domain is finally out in @NAR_Open :

https://t.co/sCQwkjKC5m

[Manchester Cancer Research Centre @MCRCnews]

👏 We're delighted to have been awarded £5.9m from @CRUKresearch to develop new radiotherapy technologies and techniques over the next five years.

Read more about the new funding: https://t.co/s8k9ZmMcre

@TheChristieNHS | @OfficialUoM

[Jonathan Pruneda @jnpruneda]

Check out this beautiful study from @imPeiYee, now published in @JCellBiol!

[Aga Gambus @AgaGambus]

Another chance to join us at Birmingham. This time open also to ECRs and junior independent researchers. Genome biology is one of the priority areas (as is cancer and RNA biology). Have a look 😀. Get in touch 😀

[Benjamin Foster @BenjaminFozzy]

Lots of engaging questions, insights, networking, and candid sharing of career experiences from all the fantastic speakers at the Early Career Symposium! Thankful to @BiochemSoc for organising! #careers #ECR #BiochemEvent

[Dr Melanie Seaton, PhD 🧬 @MelaniePHSeaton]

Dr Melanie Seaton, PhD 🎓

Today was the perfect graduation day and I was so lucky to celebrate this frankly massive achievement with my wonderful family, partner and friends. I’m so so grateful to you all. On to the next adventure!! 💖🎓💫

[Keith Caldecott @keith_caldecott]

Dear all, here is a new paper describing some of Sophie’s lovely PhD work on KU80-binding motifs (KBMs) and replication stress. It’s very interesting (he said, totally unbiased)!

https://t.co/HIw8Up6870

[Genome Stability Lab @C_K_Schmidt]

Fantastic - congratulations!

[Genome Stability Lab @C_K_Schmidt]

Congratulations to Dr Zac Sandy for passing his viva today 🎓🎉🎊🍾🥂 A big thank you to the examiners Drs Stefan Meyer and Alex Garvin for their help, time and excellent examining, and thank you also to Kiran Batta for jumping in as independent chair in the last minute!

[Genome Stability Lab @C_K_Schmidt]

Check out this project if you're interested in interdisciplinary research addressing how ubiquitin-like proteins regulate cell signalling in the context of the DNA damage response and cancer
https://t.co/T5cWJDl0Fn

[Benjamin Foster @BenjaminFozzy]

Interested in early detection of #ovarian cancer and looking for a highly collaborative project?
Look no further than the #postdoc position now open in the @C_K_Schmidt group to identify Novel Early Markers for Ovarian cancer (NEMO). Apply and more detail: https://t.co/GSY6m26iGr

[Benjamin Foster @BenjaminFozzy]

📢New #review on DUBs and ULPs in genome stability now available and open access in @Biochem_Journal #Biochemj @PPPublishing. We try to give an overview of Ub/UBL erasers in DNA damage response pathways and the mechanisms involved. Check it out! https://t.co/A1rqYg0xO0

[Kiran Batta @Kiran_Batta]

Don't miss out! Applications for this studentship end in a week. DM me if you are interested.

[The Blackford Lab @DrAndyBlackford]

We’re #hiring! Multiple #postdoc positions will be available in my lab to study DNA damage response signalling from June onwards. Get in touch with your CV if interested. Please RT!

[Genome Stability Lab @C_K_Schmidt]

A postdoc position is available to join the group as part of an international consortium to address bottlenecks in early detection of ovarian cancer. Have a look here to find out more and apply if you're interested: https://t.co/bEboq6l5qQ

[David R. Liu @davidrliu]

Today in @Science_Magazine we report the laboratory evolution of compact degrons that enable targeted protein degradation triggered by an otherwise-inert small molecule, a multidisciplinary study that integrates organic chemistry, molecular glues, protein evolution, genome editing, and structural biology.
PDF: https://t.co/cCVLKL0w8Y
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