Aging is arguably the root cause of most major diseases (loss of function in our cells). Four years ago, we made a bet that aging was treatable, and NewLimit was born.
NewLimit now has a prototype drug that reverses the age of some human cells (restores function they had when they were younger), and a clinical trial scheduled for next year (with more drug candidates in the pipeline).
Grateful to Founders Fund, Thrive, Greenoaks, and the rest of the investors for this latest round. @jacobkimmel and the team are just getting started.
BUSINESSES ARE NOW USING PREDICTION MARKETS TO HEDGE PROMOTIONS LOL
A BAR IN NYC HAD A PROMO IF THE KNICKS WIN, THEY COVER EVERYONE’S DRINKS FOR THE NIGHT
THE BAR PLACED A $5K HEDGE ON KALSHI THAT PAYS OUT IF THE KNICKS WIN
THE BAR WINS EITHER WAY
the craziest part now is that the modern computer probably has to be entirely reinvented, from scratch. pretty much like how jobs & co brought apple ii to market.
like not improved. not given a chatbot sidebar or something but really from the ground up like the iphone redefined what it meant to be a pocket computer.
the current paradigm for computers was built around a human staring at a screen, moving a cursor, opening apps, managing windows, naming files, remembering where things live, & manually translating intent into interface actions.
that made sense when the human was the runtime. but in an ai native world, it starts to look kinda ridiculous.
you can see this ridiculousness when you use computer use agents… they are useful sure, but they’re also obviously transitional. they’re teaching ai to operate machines designed for humans, which is clever, but also kind of absurd. it’s like making a robot hand so it can use a doorknob instead of asking why the door needs a knob at all. yes i know humans also need to use a door knob, but maybe in the future humans don’t need to use a computer, or at least what we think of a computer today at all.
this all leads to some interesting questions:
- what is a file when the system understands context?
- what is an app when intent can route itself?
- what is a desktop when work can be decomposed, executed, monitored, & summarized by agents?
- what is a browser when the agent can retrieve, compare, transact, & remember?
- what is an operating system when the primary user is no longer just a person, but a person plus a swarm of delegated intelligences? or no person at all.
the old computer assumed navigation.
the new computer has to assume a new kind of intention. the old computer organized information. the new computer has to try to organize agency.
we’re still in the hacky middle stage at the moment with sidebars, copilots, agents clicking through legacy ui, & automation layers sitting on top of 40 year old metaphors.
the new computer is likely one where memory, context, identity, permissions, tools, agents, & interfaces are native primitives. this means desktop, mobile, browser, apps, files, folders deserves another first principles look.
Much of any digital job is now preparing context for AI models.
Organizing files in folders, naming everything correctly, introducing things in the right order, and only then asking the AI to do something in clear written English.
There'll always be more emails in need of reply, more meetings to attend, and more updates to read. A person can fill the entire workweek with these tasks over and over again. But to stay sane and sharp, you must pay yourself first by doing the work that actually means something to you.
I feel this acutely as someone responsible to employees, customers, followers, and readers. I could do nothing all day but check up on projects, people, and posts, but my brain would quickly check out if it was just doing that.
So quite frequently, I just don't. Don't check in, don't check up, and instead dive into the work that checks my own intellectual boxes. Programming for the love of it. Experimenting for the hell of it. Researching for the fun of it.
In another age, I might have been tempted to apologize for such privilege, but screw that. Privilege is wonderful. You should do your best to earn more of it. Even if you have to carve it out of the bare rocks around you.
Ironically, the best way to do that is also to choose to always pay yourself first, however little at first. By solving your own problems, tickling your own interests, chasing your own curiosity. That's where you'll find the motivation to elevate your talent. To turn interest into competency.
And once you've developed some competency, you'll be rewarded with more privilege to build it further. This is the virtuous circle of merit.There'll always be an endless list of work that could be done.
You'll never get through it all and onto your own priorities, if you continue to put them at the bottom.
@VictorTaelin I played it so much man. It was one of the most fun times I've had as a kid. Seeing Taelin's features compared to regular Tibia opened my eyes to the possibilities of coding. I actually tried replicating a lot of Taelin's features and ended up learning a ton because of you.
Recipe for insane development speed:
Git worktrees + AI agents = parallel coding superpowers
While one agent fixes issue #361, another tackles #305, and a third investigates that user bug report—all without conflicts.
This changes everything.
Faaala galera 🗣️ Passando pra apresentar pra vocês O Pato de Borracha! Um show semanal e comunidade no Discord p/ quem gosta de produto, tech, negócios e uma conversa descontraída e despretensiosa: as vezes somos acompanhados de uma cerveja e falamos de…https://t.co/QTkLJkC2kx
@fwuensche Looks slick! Congrats. Have you thought about ways "automating" the config file? I always wanted to build some kind of linter for anti patterns. Maybe w/ ChatGPT you could use it to do something like that for cherrypush!
Developing a mindset of boiling things down to basic principles - problems, goals, thoughts, processes, conversations, what have you - and thinking about these things in terms of its basic structures is incredibly clarifying. And often really hard.
“For the simplicity on this side of complexity, I wouldn't give you a fig.
But for the simplicity on the other side of complexity, for that I would give you anything I have.”
https://t.co/XQ4ujSjQIS
@SalomeSibonex Have you read Snowcrash? Without giving spoilers, one of the main elements of the plot is a cyber punk, virtual reality version of how words shape our own worlds, inner and outer. Worth a try