Adagrasib was just withdrawn by the @FDA in metastatic colorectal cancer based on the negative results in KRYSTAL-10
"A waterfall plot can look impressive, and high response rates can create enthusiasm, but they should not be confused with proven clinical benefit."
From Sahar van Waalwijk, new guest post in
https://t.co/P3NUOebqBF !
This is a big bust, folks
The first large scale (N>8000 participants) for lowering Lp(a) did not meet its primary endpoint for reducing adverse cardiovascular outcomes (vs placebo) https://t.co/dNV6RHXtJb
@VKaklamani@jhaveri_komal@mayscancer@MSKCancerCenter But She is pointing the pharmacokinetics issues of Fulvestrant whereas i obtained from Fabrice andre à prescription of 250mg every 14 days, since last year in order to tackle these pharmacokinetics issues. Why are you not doing this????
@alfredfischer17 And « mature » means nothing in eBC because most of us are not supposed to Die!!! Therefore you Will never reach « maturité »! What is important to us is RAPID efficacy on OS With limited toxicity, as we have With taxanes for instance! Ribociclib is MORE toxic than standard chemo
@Dr_Doc_ They found no advantage because they decided to deprive their victims from aromatase inhibitors or Fulvestrant while on chemo, so to jeopardize the efficacy of chemo!
@jrgralow@FayUCCancerCr@ASCO One main reason is because oncologists do so many unethical trials, which takes a lot of Time and energy, And kills us, while they should take care of us instead!
🥵 Les mots manquent pour qualifier cet été météo : exceptionnel, inédit, historique, hors norme...
Et ses impacts sur la #santé s'annoncent majeurs, dans l'immédiat (des milliers de morts notamment) et sur la durée.
🎙️ Récit en podcast 👇🏻 @le_Parisien
https://t.co/wAQWZgc49R
@myESMO@DFCI_BreastOnc@E_de_Azambuja@Prof_Nadia_H They refuse to inform thé eBC patients victims about acquired resistance deliberatly triggered by eBC exposure to CDKi! Shame on them, not even referencing their own article!!!
https://t.co/lIiOj3UAl8
P-VERIFY
▪️Large real-world study comparing CDK4/6 inh + AI in 1L HR+/HER2− metastatic breast cancer
▪️No significant differences in OS or real-world PFS between palbociclib, ribociclib, and abemaciclib
"Thank you very much"
https://t.co/sqBalHs0q1
Cognitive dysfunction associated with endocrine therapy and CDK4/6 inhibitors in breast cancer: A real-world analysis of the FDA Adverse Event Reporting System (FAERS) database https://t.co/b35r39IbvU @WilliamDale_MD@myCARG#GeriOnc#OlderAdults#OncoAlert#SIOG#YoungSIOG #Elsevier #CDK46Inhibitors
#Cognitive #FAERS