Casey Detrio

[Casey Detrio @cdetrio]

Was chatting with @josephch yesterday and he asked a great, but dreaded, question: how will the eth1 chain, all the existing eth1 contracts, and users fit into the eth2 roadmap (Serenity) long-term, as focus shifts to the eth2 launch?

[Steven Salzberg 💙💛 @StevenSalzberg1]

Yet another major blow to the hypothesis that a microbiome of cancer exists. TLDR: the main results from a 2020 @ScienceMagazine paper claiming to find bacteria in breast cancer simply doesn't hold up. Well done @NFdeMiranda, Jacques Neefjes, et al

[Casey Detrio @cdetrio]

@Ryan_Mac_Phd @SaskiaPopescu @angie_rasmussen @KatherineJWu Can you elaborate on the right circumstances? I'm not finding any specific recs of where/when it'd be most useful to screen using rapid tests, versus diagnose using PCR. (Seems to be lost in the dunking from both sides - "PCR is too slow", "rapid tests are no silver bullet").

[Casey Detrio @cdetrio]

@jefflau @ChihChengLiang In all seriousness though, what's the math on block withholding or otherwise biasing validator selection?

[Casey Detrio @cdetrio]

@SMBrocklehurst @Dereklowe Sitting casually in my armchair, if I may, I think the breakthrough here is not so much knowing the 3D structure of a target protein. But knowing the 3D structure of all the proteins.

[Casey Detrio @cdetrio]

[2 years ago, paraphrasing]: "Perhaps in four years, if we assume that the trendline continues, and we have no real reason to believe that it will, at least not without new conceptual breakthroughs."

Today: "Pretty much solved." "I think it's over."

https://t.co/dMVhHsmRMC

[Casey Detrio @cdetrio]

2 years ago: "substantial progress [...] Great! Does this mean the problem is solved, or nearly so? The answer, right now, is no." ...

[Mohammed AlQuraishi @MoAlQuraishi]

CASP14 #s just came out and they’re astounding—DeepMind looks to have solved protein structure prediction. Median GDT_TS went from 68.5 (CASP13) to 92.4!!!! Cf. their 2nd best CASP13 struct scored 92.8 (out of 100). Median RMSD is 2.1Å. I think it's over https://t.co/dQ1BOJWuwn

[Mohammed AlQuraishi @MoAlQuraishi]

Nature's write-up: https://t.co/aQZkFN0Mmz

[Casey Detrio @cdetrio]

@haydenzadams People think if most of the code is copy/pasted they don't really need an audit

"Consensus is [it's] unnecessary other than to assuage [..] folks unfamiliar with the drag and drop contracts we are using."

"We actually have very little custom code."

https://t.co/j8lMh5gyE6

[Casey Detrio @cdetrio]

@dankrad @QwQiao If you can find two uncorrelated and volatile assets, a "volatility harvesting" strategy would be profitable (aka volatility pump or Shannon's demon), iiuc. Assets become (short-term) correlated b/c uncorrelated volatility is an arbitrage opportunity.

https://t.co/ni4tdWJKRz

[Casey Detrio @cdetrio]

@peterontheblock @VitalikButerin Obfuscation would let you deploy "encrypted bytecode" that holds a privkey. We'd have wrapped BTC with no trust - the contract could sign BTC transactions using a privkey in obfuscated bytecode (despite being public bytecode, the privkey remains secret because it's obfuscated).

[Casey Detrio @cdetrio]

@peterontheblock @VitalikButerin WBTC (Wrapped BTC) is an erc20 backed 1:1 with Bitcoin held at Bitgo Trust, because you can't put a BTC privkey in an erc20 contract (well you could, but anyone could see the privkey in the deployed contract).

[Casey Detrio @cdetrio]

@QWQiao A few days ago you said you were wrong about Uniswap. Have you changed your mind? https://t.co/JOCLwnziC7

[Casey Detrio @cdetrio]

@jaybny @QWQiao Yes, it uses limit order books. With one weird trick (market makers hate it!) that makes it better than a continuous-time l.o.b. - batch matching - so your order may fill at a price *better* than your limit price.

[Casey Detrio @cdetrio]

@jodiecongirl Kind of a dual to https://t.co/F8xIex5JQK

[Casey Detrio @cdetrio]

@buchmanster @emrec90 Any examples of genuinely new bottom-up systems (connected to real world local economics)?

[Casey Detrio @cdetrio]

@derekmadden @PeterLBrandt https://t.co/Me5W2vRXpx

[OM @OMP800]

@LocksleyFletchr @odanu @AndySwan At 40 seconds in you clearly here her call them the n word!?!?!?

[ALT-immigration @ALT_uscis]

The America we want:
Flint sheriff took his riot gear off and marched with protesters instead. https://t.co/6URGXrN74f

[Casey Detrio @cdetrio]

@WesPegden @jfeldman_epi @nataliexdean A society with "no lockdowns" might have worse economic disruption than one with lockdowns (if infections spread exponentially...). Also, "locking down" doesn't mean stop producing food. The UN warns of global food shortages due to tariffs and export bans, not social distancing.

[Casey Detrio @cdetrio]

@naval @kunalb11 Scale up testing, and open up for good (no risk of re-closing, ref. @paulmromer).

Game of open-close green vs red zone whack-a-mole might not be any better than nationwide closure (voluntary or involuntary). Uncertainty of future status is what kills an economic restart.