Charles Berger

[jonathan @ChangeUrBeliefs]

every once in awhile you find a youtube video of such pure unadulterated greatness you have to share it

in 2 minutes this guy solved a decade of bicep and shoulder tightness and small recurring tears

may God shine countless blessings upon this man

[Hans Amato @HansAmato]

Serious question:

If something can double the effectiveness of your antidepressant...

Why wouldn’t you use it?

That's clostridium butyricum for you. A probiotic.

[Paul F. Austin @PaulAustin3w]

Most people have never heard of microdosing iboga.

That’s about to change.

A man in Germany was diagnosed with early onset Parkinson’s at 41. By 51, he was completely bedfast. As a last resort, he had holes drilled into his skull for deep brain stimulation. It gave him some mobility back but not much.

Thirty days later, he signed up for assisted suicide.

Before going through with it, he connected with a researcher at the University of Zurich named Tobias Emmery who had been studying ibogaine, a psychoactive compound from a West African plant called iboga.

The protocol was an upwardly titrated daily low dose over four weeks.

It restored normal motor function, so he left his 24/7 nursing home, moved in with his mother, and was riding a bicycle three miles a day.

INSANE!

This is one of roughly 50 cases Emmery has studied. The efficacy is around 50% and seems confined to genetically rooted Parkinson’s rather than environmentally triggered cases.

It’s not a silver bullet. But for the people it works for, there is nothing else in medicine that comes close.

Parkinson’s is just one piece of the picture.

Stanford published a study in Nature Medicine showing that a single ibogaine treatment in 30 special operations veterans with TBI produced average reductions of 88% in PTSD, 87% in depression, and 81% in anxiety. The late Dr. Nolan Williams, who led that research, said no other drug has ever been able to alleviate the functional and neuropsychiatric symptoms of traumatic brain injury.

Brain imaging revealed neurorestorative effects including white matter regeneration across the brain’s surface, something previously unheard of in medicine.

The mechanism appears to involve GDNF, a growth factor that supports the survival of dopamine-producing neurons, which are the exact neurons that degrade in Parkinson’s and other neurodegenerative diseases.

This is no longer fringe.

Brett Favre is using ibogaine through Ambio’s neuroregenerative program for his Parkinson’s diagnosis and has reported improvements in sleep and energy.

Conor McGregor underwent treatment at the same clinic for TBI and trauma and said it saved his life.

Texas approved a $100 million initiative to fund FDA clinical trials for ibogaine, one of the largest government investments in psychedelic therapy ever.

Ibogaine is still a Schedule 1 substance in the US.

But for conditions like Parkinson’s, MS, TBI, and opioid addiction, there is a growing body of evidence that this plant does something to the brain that we don’t fully understand yet and that nothing else can replicate.

We may be looking at the most important neurodegenerative medicine that nobody is talking about.

[Charles Berger @charleswberg]

@MelRoBuilds CoQ10 did this for me.

[Bryan Johnson @bryan_johnson]

I'm experimenting with 5-MeO-DMT because it may be most underrated longevity molecule no one is talking about.

+ Accelerated neurogenesis: a single dose more than doubled brain cell proliferation and neuronal regeneration in the hippocampus within 12 hours, alongside measurable increases in synaptic density and firing frequency in rodent models.

+ Proteomic reorganization: in human cerebral organoids, 5-MeO-DMT triggers rapid proteomic shifts favoring cellular reorganization and synapse formation. Early evidence of structural brain renewal at the molecular level.

+ Default Mode Network reset: The DMN calcifies with age locking us into rigid, repetitive patterns of thought. 5-MeO-DMT disrupts these patterns, restoring bottom up connectivity between sensory and creative brain regions. A forced return to neurological flexibility and youthfulness.

+ Systemic anti-inflammation: suppresses pro-inflammatory cytokines (IL-1β, IL-6, TNF-alpha) while upregulating IL-10, the anti-inflammatory signal. Mediated through the Sigma-1 receptor, suggesting a mechanism distinct from other psychedelics.

[Teddy - PolyBackTest.com @Bitcoin_Teddy]

This Radiologist:

"If I have cancer, I won’t go to the hospital."

"I’ve seen too many people die from chemo, not from cancer."

"I’ll fast for 30 days and I’ll stop working."

[Seth @seth_fin]

Imagine a father who secures $100,000 in spot Bitcoin.

He holds the asset until the valuation hits a massive $5,000,000.

Liquidating the position directly triggers devastating taxes on $4,900,000 of pure profit.

So he executes the perfect institutional maneuver instead.

He locks the Bitcoin in a legal trust, takes out a collateralized loan against the stack, and lives off the borrowed liquidity.

Because he never executed a sale, his tax liability remains at absolute zero.

Upon his death, the heirs receive the Bitcoin with a brand new cost basis set exactly at $5,000,000.

The government cannot legally touch a single cent of the accumulated gain.

This is exactly how generational wealth is permanently secured.

[The Primal Diet by Aajonus Vonderplanitz @primal_diet]

Cancer is a solved problem ever since Aajonus fixed it decades ago (97% success rate), and he is now blowing up on TikTok and IG.

See below.

[healthbot @thehealthb0t]

This should be posted everyday by thousands. Over and over.

[Carnivore Aurelius ©🥩 ☀️🦙 @AlpacaAurelius]

Ladies, you need to be wearing cotton underwear.

Polyester underwear on dogs tanked their progesterone 90 PERCENT from 50 ng/ml to 5 ng/ml...and 75% of them couldn't get pregnant.

Polyester creates an electrostatic field that disrupts hormone production

100% cotton only if you want babies

[gemchanger @gemchange_ltd]

https://t.co/bVArkKPyv1

[Moosa @questmoosa]

Hashimotos and Vitamin B1

600mg/day of B1 in patients with Hashimoto’s thyroiditis, led to partial or complete regression of the fatigue and related disorders within a few hours

Thiamine also prevents bad symptoms of hypermetabolism, such as the rapid action of the heart, nervousness and digestive disturbances, during thyroid treatment

Absolutely fascinating!

[Helen @anomalie_blue]

A 1945 study also used 4-6g oral glycine to treat depression/suicidal ideation. Only 3 of the 19 patients did not benefit. Below is a list of some of the patient profiles and their improvements:

60,F after treatment with glycine doctor notes that “patient is a changed person. She not only smiles but laughs…is again very energetic” patient says “I can control my depression”

20, F no interest in her baby, crying constantly. Recovered fully after a few weeks’ treatment with glycine

52, M impotent, lacking ambition, claimed to be “tired of living”. 7 weeks glycine treatment patient says he is “no longer blue”

45, F depressed, would sit for hours and bite nails. 2 months on glycine resulted in resolution of mental symptoms

27, F suicidal with children, no ambition to care for them. Treated with glycine, doctor notes “patient feels much better, was profuse in her thanks”

35, F registered nurse who would cry all the time before treatment notes “I feel better, I feel like doing things again”

[Hans Amato @HansAmato]

day in the life of a self-diagnosed "introvert":

- wakes up tired
- skips breakfast or eats cereal
- dreads any social plans
- cancels last minute
- gets drained after 1 hour with people
- needs a full day to "recharge"
- goes home early from everything
- cold hands the whole time
- calls it "just who I am"

nah bro you're inflamed

I was the most "introverted" person you'd ever meet. Needed to "recharge" after socializing. Got drained in groups. Avoided parties. Left early. Made excuses. Had a whole identity built around being a quiet person who needs alone time

Then I fixed my gut, lowered my inflammation, ate enough food, and restored my GABA tone

Suddenly I was the guy staying out late. Starting conversations. Walking into rooms with energy instead of dread. Didn't need to "recharge" after being around people because being around people stopped costing so much energy

When your nervous system is stuck in sympathetic overdrive (which happens when you're inflamed, underfed, and running on stress hormones), every social interaction triggers a low-grade threat response. Your brain is scanning for danger. Processing faces. Monitoring tone. Running threat detection on every human in the room

That's exhausting. Obviously you need to go home and "recharge." Your brain just ran a 2-hour surveillance operation at dinner

Drop the inflammation. Feed the system. Restore inhibitory tone (GABA, allopregnanolone, progesterone metabolites). The social battery expands because the social cost drops

I'm not saying introversion doesn't exist btw. Some people actually prefer solitude and that's fine. But if you WANT to be social and you CAN'T without getting drained or anxious, that's a metabolic problem wearing a personality label

The quiet kid in the corner might not be introverted. His nervous system just can't afford the energy cost of a conversation

Fix the body. See if the personality changes. You might be surprised who's been hiding behind the inflammation

[Dr Sam Soete @sam_soete]

Thiamine/B1 is prob the best single example of why micronutrient maxxing matters at a systems level (if you are gonna read this, then read the whole thing)

B1 is a cofactor for pyruvate dehydrogenase. PDH converts pyruvate → acetyl-CoA. This is THE gateway reaction between glycolysis and the Krebs cycle. Without adequate B1, this step bottlenecks. Pyruvate backs up, gets shunted to lactate instead. You can see this happen on Metabolomix+/OAT testing or just measuring finger-prick lactate.

No acetyl-CoA = no NADH/FADH2 feeding the ETC = ↓ ATP across every cell. You can eat plenty of glucose and still not be able to turn it into usable energy which is when people run into issues with eating high carb.

BUT B1 does way more than just energy.

PDH also produces acetyl-CoA for acetylcholine synthesis. ↓ B1 → ↓ ACh → impaired vagal tone → ↓ gut motility, ↓ HCl secretion, ↓ bile flow, ↓ heart rate variability, ↓ parasympathetic tone overall.

This is one of the core drivers of a lot of people's gut issues btw. It is why B1 deficiency can present as POTS-like symptoms, gastroparesis, chronic constipation, weird heart rate issues.

And then you have transketolase enzyme in the pentose phosphate pathway which also needs B1. This pathway produces NADPH (key for antioxidant defence, glutathione recycling, fatty acid synthesis etc) and ribose-5-phosphate for DNA/RNA synthesis and repair.

Branched-chain alpha-ketoacid dehydrogenase (another enzyme) is also B1 dependent. This enzyme catabolizes branched chain amino acids. ↓ B1 → ↑ BCAA accumulation. Also something you can sometimes pick up on metabolomix+ testing altough arguably NutrEval is a lot better for this.

So from ONE micronutrient deficiency you get a whole bunch of shit going wrong:

- ↓ ATP production
- ↓ Acetylcholine → autonomic dysfunction
- ↓ Gut motility and full digestive cascade
- ↓ Antioxidant capacity (NADPH)
- ↓ DNA repair substrate
- ↑ Lactate (exercise intolerance, muscle pain)
- ↑ Dysfunctional BCAA and amino acid metabolism

Youend up with fatigue, brain fog, poor digestion, slow motility, exercise intolerance, and autonomic dysfunction.

Maybe in the centralized system you get 5 different diagnoses and 5 different specialists, and a dozen drugs. No bueno.

B1 demand scales with carb intake btw. Higher carb = more pyruvate = more PDH activity needed = more B1 required. High calorie modern diets with refined carbs are essentially increasing B1 demand while providing almost none of it - this is what Dr Lonsdale figured out!

Alcohol does the same as it inhibits B1 absorption and ↑ urinary excretion.

This is what systems biology looks like at the micronutrient level. One cofactor touching everything.

[Joseph Parker @JosephAP89]

Brilliant

[Dalton (Analyze & Optimize) @Outdoctrination]

MITOQ - A mitochondrial targeted energy enhancer 100-1000X more potent than Coenzyme Q10.

Reactive oxygen species (ROS, think free radicals) completely destroy our cells, our ability to generate energy and the structure our tissues, contributing to:

➔ Fatigue
➔ Signs of aging
➔ Disease

but 90% of these ROS are produced in the mitochondria.

Problem is, most antioxidants don't reach the mitochondria, leaving them susceptible to damage.

MitoQ solves that problem.

It’s a modified version of CoQ10, bound to a lipophilic cation (TPP⁺) that uses the mitochondrial membrane potential to specifically accumulate inside the mitochondrial matrix.

This makes it incredibly powerful:

◈ Neutralizes superoxide and peroxynitrite - highly damaging ROS
◈ Prevents cardiolipin oxidation - a key membrane component that mitochondria need to work properly
◈ Stabilizes mitochondrial membrane potential
◈ Preserves ATP output under stress

MitoQ is drawn into mitochondria ~100–1,000x more effectively than Coenzyme Q10, where it acts directly at the source of damage.

Some of the benefits in studies include:

◈ Reduced fatigue
◈ Reduced markers of oxidative stress (MDA, 8-OHdG, nitrotyrosine)
◈ Improved endothelial function (blood vessels)
◈ Lower blood pressure
◈ Improved fatty liver
◈ Enhanced cognitive function
◈ Slower telomere attrition and DNA damage in aging cells
◈ Improved mitochondrial biogenesis markers (PGC-1α, NRF1)

Typical dose: 5 - 10 mg/day, sometimes up to 20 mg depending on the condition.

[Mitopapi 🧬🕊️ @Mitopapi]

A lot of people with MTHFR mutations are told to take methylfolate and methyl-B12. For some, it works great. For others, it causes anxiety, irritability, racing thoughts, and insomnia.

Nobody explains to them why this happens. Here's the leading hypothesis:

Methylfolate and methyl-B12 increase SAMe, which is your body's primary methyl donor. SAMe feeds COMT, the enzyme responsible for breaking down catecholamines like dopamine and norepinephrine.

If you have slow COMT variants (which is quite common), you're already dealing with higher catecholamine levels at baseline. Adding extra methyl donors into this equation may amplify that buildup in sensitive individuals.

This is why many clinicians in the functional medicine space have success switching these individuals over to hydroxocobalamin and folinic acid.

Hydroxocobalamin is a non-methylated form of B12. Your body can still convert and use it, but without dumping a heavy methyl load into the system all at once.

Folinic acid works on a similar principle. It supports folate-dependent reactions but bypasses the direct methylation pathway that methylfolate pushes.

Together, these two forms give you the cofactor support you need without overwhelming the very pathways that are already struggling to keep up.

No large scale studies have confirmed this yet, but it's a well-recognized clinical pattern so it’s worth discussing. If you've taken methylated B vitamins and felt worse, this MAY be why.

[MarginCalled @JPowFleshlight]

take your fucking glycine anon,

it improves sleep quality,
boosts antioxidant defense,
supports metabolic health,
promotes heat and cardiovascular protection,
is anti inflammatory,
is anti aging,
and it's cheap as fuck

stop making excuses

[Basil the Great @BasilTheGreat]

The EU Parliament voted on whether only biological women can get pregnant

Result:
200 in favour ✅
233 against 🚫

The EU believe men can get pregnant 🤡