Nir Ben Chetrit

Tumor microenvironment and immunology of breast cancer.
Weill Cornell Medicine. #breastcancer | #Immunotherapy | #SpatialBiology.

[Samuel Hume @DrSamuelBHume]

Big Nature paper this week on improved lifespan (in mice!) using an antibody to block IL11

Old mice without IL11 even look healthier

🧵

[Nature Rev Immunol @NatRevImmunol]

NEW @preprintclub Journal Club from Anthony Altieri & Matthew Buechler @ImmunologyUofT discussing @biorxivpreprint by @ChetritNir @landau_lab @Johanna_A_Joyce that investigates the mechanisms regulating macrophage heterogeneity in breast cancer
https://t.co/XuzFfpnbNB

[Nir Ben Chetrit @ChetritNir]

@ktsanov @LoweLabMSKCC @MSKCancerCenter Congrats Kal!

[Nir Ben Chetrit @ChetritNir]

@BrownLab_KUMC @AACR Hey Kristy!
Let’s catch up.

I’m presenting our work on the 9th

https://t.co/xPzfM2k8Hf #AACR24

[Jennifer Bailey-Lundberg @DuctalvsAcinar]

🔬Ready to delve deep into the #TumorMicroenvironment @AACR? Join @LabMcgaha and me as we co-chair the symposium “The Microenvironment: Beyond Surrounding the Tumor.��
Featuring talks by @ChetritNir @danielzabransky @neilqtay @GauriMirji Jun Li, Ruiyuan Xu, & Xiaoyu Yuan #AACR24

[Nir Ben Chetrit @ChetritNir]

@DuctalvsAcinar @AACR @LabMcgaha @danielzabransky @neilqtay @GauriMirji Looking forward!

[Magdalena Matusiak @MagdaMatusiak]

Very excited to share our work with @MattRijn @johnhickey22 @GuolanLu @luca_bogdan @GarryPNolan @BrubakerSky @kidzik Rob West @Stanford spatially dissecting macrophage niches in human breast and colon benign and tumor tissue. https://t.co/8qLiTdHCOz

[Nir Ben Chetrit @ChetritNir]

@ktsanov Congrats Kal!!

[Kal Tsanov @ktsanov]

Excited to share our latest preprint! Here, we asked: Does a tumor’s dependence on driver mutations change after it spreads to other organs? This led us to uncover a critical interplay b/w tumor #Genetics, #Epigenetics and #AnatomicLocation... 🧵 1/n
https://t.co/Ro6vhUw8Wd

[Darko Barisic @LabBarisic]

Very excited to share our new paper on how mutations in SWI/SNF chromatin remodeling complexes alter chromatin dynamics and immune cell-fate to drive lymphoma, online now in @Cancer_Cell.
https://t.co/jE1QzkSVXh

More details in the thread below.👇 🧵 1/n

[Kevin Bishop @Kevin_W_Bishop]

Our end-to-end workflow for 3D pathology is now published in @NatureProtocols!

This includes all the steps to go from archived pathology tissues to 3D H&E-like datasets, with an emphasis on quality control for large studies.

Full text at: https://t.co/MfPzUCe3aJ

[Tirosh Lab @TiroshLab]

We’re excited to share our preprint on spatial organization in glioblastoma: https://t.co/OTaanCDDXG. We combine spatial transcriptomics (Visium) and proteomics (CODEX) to reveal a five-layer organization of cellular states and highlight a role of hypoxia as tissue organizer. 1/

[Nir Ben Chetrit @ChetritNir]

@NCIDanMcVicar @landau_lab Thanks Daniel! We will check it out.
Feel free to reach out and discuss the oTME details.

[Nir Ben Chetrit @ChetritNir]

Very excited to share our latest work from the @landau_lab, where we uncover the spatial determinants underlying macrophage heterogeneity and self-renewal in breast cancer. https://t.co/GMh8o1mHHq

[Nir Ben Chetrit @ChetritNir]

@IKeklikoglou @landau_lab Thanks Ioanna!

[Nir Ben Chetrit @ChetritNir]

@DanielaQuail @stevexniu @landau_lab @Joycelab @BrownLab_KUMC @Neil_Iyengar @LoweLabMSKCC @LabSagi Many thanks Daniela!

[Nir Ben Chetrit @ChetritNir]

Fantastic team science with @stevexniu, Jesus Sotelo, and many more members of the @landau_lab, @Joycelab, @BrownLab_KUMC, @Neil_Iyengar , Dilip Giri, @LoweLabMSKCC , John Healey, Frederic Geissmann, and @LabSagi

[Nir Ben Chetrit @ChetritNir]

pls check @TylerEMiller and @BradEBernstein, who have posted an exciting story on transcriptional programs of myeloid cells in glioma, similarly linking myeloid cell plasticity and TME niches as drivers of immunomodulation https://t.co/fH4e9bVoGm