Benedict MH Choi

Postdoc in Goodarzi lab and Konermann lab @Arcinstitute. PhD in Molven lab & @Halberglab1 at @UiB. RNA, systems biology, cancer and stem cell-derived models.

[Benedict MH Choi @choi_benedict]

Happy to share this work of ours coming from the fun collaboration between the Goodarzi lab and Jain lab, where we show that systematic hypoxia suppresses solid tumor growth! Check out the detailed tweetorials from my co-author and the preprint below!

[Ayush Midha @AyushDMidha]

I am excited to share our latest preprint, in which we demonstrate that systemic hypoxia suppresses solid tumor growth.

This has been a tremendous collaborative effort in the labs of @IshaHJain and @Genophoria at @GladstoneInst, @ArcInstitute, and @UCSF.

https://t.co/bzsPY2nWVs

[Hani Goodarzi @genophoria]

We are excited to introduce LoRNA-SH, a frontier RNA foundation model that leverages long-read transcriptomics and long-context inputs to learn and predict the transcriptome architecture with base-pair resolution: https://t.co/8hfWJ54lHS

[Ophir Shalem @ophirshalem]

Excited to share our new paper where we explore why dCas9-KRAB protein levels drop so drastically after neuronal differentiation in WTC11 and KOL2.1J iPSC lines.
https://t.co/SBRXfWau75

[Benedict MH Choi @choi_benedict]

Check out our latest work in collaboration with @hsnajafabadi lab!

[Hamed Najafabadi @hsnajafabadi]

What is the best strategy to quantify mRNA isoforms? Short-read RNA-seq to achieve high depth? Or long reads to get unambiguous read-isoform assignments? In our latest work with @genophoria, we show that what we really need is to combine both! (1/n) https://t.co/Meev1Mcbqd

[BrianWooSciAcc @brianjwoo_bio]

(1/17) Excited to share our latest collaborative study from the labs of @genophoria and @felixfengmd! tl;dr: we developed an integrative platform to identify and deeply characterize non-coding drivers of prostate cancer progression. More to follow~ https://t.co/6MxU2hehqZ

[Matvei Khoroshkin @khorms57]

RNA folding affects gene expression, but this link is not well explored in Eukaryotes. We researched RNA structural switches and discovered hundreds of them in the human transcriptome. We even visualized some of their 3D folds with CryoEM. Thread below: https://t.co/JH1tbeXPLc

[Matvei Khoroshkin @khorms57]

Can’t wait to share the splendid results of the collaboration between the incredible labs of @genophoria, @FKHM, and @halfacrocodile! Tl;dr: we've explored the code on how RNA-binding proteins team up to regulate their target RNAs. Read on for more! (1/15) https://t.co/d1xvd31Qay

[Benedict MH Choi @choi_benedict]

If you like cool science, and would like to experience the beautiful city Bergen, Norwegian cultures and nature, check this out!

[Halberglab @Halberglab1]

If you are interested in spatial aspects of the tumor ecosystem and how this can be manipulated by physiological stressors (obesity, exercise, fasting) check this out and come and join the lab:

https://t.co/0XbzGlMhej

[Benedict MH Choi @choi_benedict]

@Chemystified Hey! I am interested in joining!

[Benedict MH Choi @choi_benedict]

It’s always nice to be back and connect with previous mentors @Halberglab1

[Benedict MH Choi @choi_benedict]

Have heard about this exciting story several times during the lab meeting and it is nice to finally see it out. Congratulations to the coauthors!

[Benedict MH Choi @choi_benedict]

If you are interested in cancer research, definitely check out this opportunity! Albertas is a great enthusiastic mentor/scientist and has tons to molecular tricks you can learn from!

[Albertas Navickas @a_navickas]

Are you a recent MD graduate and interested in using stem-cell derived organoids for cancer research? @Emerald_Science has multiple MD-PhD fellowships, including in my lab at @Institut_Curie. Apply before 8/28 or spread the word! https://t.co/zi2xe2V8pk

[Benedict MH Choi @choi_benedict]

@christie_inalab @UCSF @CSHL Great to see you again! Hopefully I manage to visit you in Stockholm in the summer!

[Benedict MH Choi @choi_benedict]

One of the work during my grad school time is finally out! We found that a transcription factor plays an important role in obesity-adapted triple negative breast cancer. Thanks all the co-authors, especially @XiaoZhengLiu1, Anastasiia and @Halberglab1.

[Halberglab @Halberglab1]

Obesity is currently linked to approx. 500 000 new cancer cases each year. What are the molecular mechanisms? Our take is now out Nature Communication: https://t.co/6wRPMMhzMb Huge congratulations to @XiaoZhengLiu1 and @choi_benedict. I am very proud of you guys.

[Marc Mendillo @MarcMendillo]

Farewell @cshlgnx! Big thanks to @tollkuhn, Robert Bronstein, and Dennis Plenker! So great to work with @AdelmanLab & @ChromaTownie, & TAs - @Roger5mith @egkaye @AlZuko1 & @bmart87! And to learn from our fantastic speakers!Most of all - the incredible students!!