Christine Hopp

Malaria & Antibodies!
Junior Research Group Leader @BNITM_de
Formerly @NIAID/NIH & @JohnsHopkinsSPH
PhD @LSHTM
Every day a little more awake.
Views my own.

[Boris Striepen @striepenlab]

Critical loss: the effects of VEuPathDB defunding on global health - The Lancet Microbe ⁦@parasitesrule⁩ ⁦@ASTMH⁩ @nih ⁦@NIAIDNews⁩ ⁦@BSPparasitology⁩ ⁦@WiParasitology⁩ ⁦@ParasiteSlack⁩ #mpm2024 https://t.co/gYO7eCPARq

[Christine Hopp @ChristineSHopp]

This tweet will change your perspective on autoimmunity. High levels of autoantibodies at healthy baseline associate with a 41% reduced risk of febrile malaria. Excited to share this great story from Kalifabougou, Mali! @MrtcParasito https://t.co/XCIhjj0iXz 🙏to all contributors!

[Immunity @ImmunityCP]

Online now: Autoantibodies inhibit Plasmodium falciparum growth and are associated with protection from clinical malaria https://t.co/F6OjdNpzVq

[Christine Hopp @ChristineSHopp]

@morethan88 @elbphilharmonie @SteinwayAndSons Fantastic performance, thanks for bringing Ellington alive in Hamburg this Friday! It’s been two years since living in DC, this brought the Kennedy center here, thank you.

[Christine Hopp @ChristineSHopp]

@morethan88 @elbphilharmonie @SteinwayAndSons Incredible, cosmic sounds last night. Thank you thank you thank you for a very special musical experience. Come again soon!

[Christine Hopp @ChristineSHopp]

@ian_cockburn @JCSMR How about virtual attendance!

[Christine Hopp @ChristineSHopp]

„Over a 25-years period, the inhabitants of [...] an area of intense malaria transmission, have been monitored daily.“ „Susceptibility to the disease may vary up to 10-fold, and for most children childhood is an endless history of malaria fever episodes.“🇸🇳https://t.co/YKYP7BD4HR

[Christine Hopp @ChristineSHopp]

Artemisinin-Resistant and HRP-Negative Malaria Parasites in Africa | NEJM https://t.co/GmzFXK1QM3

[Christine Hopp @ChristineSHopp]

@rayner_julian Thanks, Julian!!

[Christine Hopp @ChristineSHopp]

@MYA_TKJ Definitely!

[Christine Hopp @ChristineSHopp]

I am looking for a motivated #PhD student to work on a project studying the bone marrow B cell compartment during chronic malaria and tuberculosis infection!

Beautiful pipetting view guaranteed at the #BNITM_de in Hamburg, Germany

Please share with potential candidates!

[Christine Hopp @ChristineSHopp]

When it comes to antibodies, "specificity" has complex meaning.
Very interesting work! @PilewskiKelsey and @IG_lab

[Cell Reports @CellReports]

Functional HIV-1/HCV cross-reactive antibodies isolated from a chronically co-infected donor https://t.co/tuV6eh9MhF

[Christine Hopp @ChristineSHopp]

@TeunBousema An important aspect of this conversation is that conference organizers need to lay the foundation to allow virtual participation. I attended #astmh2022 virtually, but many sessions were only available in live stream, which given the time differences can’t be the way to do this!!

[NEJM @NEJM]

In this phase 2 trial in Mali, an antimalarial monoclonal antibody (CIS43LS) at the higher dose (40 mg per kilogram) was approximately 88% effective at preventing P. falciparum infection as compared with placebo. #TropMed22 https://t.co/UGeBHOPhKY

[Christine Hopp @ChristineSHopp]

@victora_lab @Rizzi_Marta Such an elegant study! 👏What is the point of all of those secondary GCs if they are non-functional/low affinity...?

[Amy Kristine Bei @TheBeiLab]

We’re hiring! Are you excited to understand the functional impact of genetic diversity on malaria vaccine efficacy in both lab and field? Do you want to be part of a truly awesome cross-continental lab family? If so, apply for this fully-funded post-doc position in the Bei Lab!

[Christine Hopp @ChristineSHopp]

@JustinTaylorLab https://t.co/CzUvtkkSGI @LeoMarWes, @marylyn_addo et al. looking at MERS-CoV-S-specific cells induced by MVA-MERS-S vaccination

[Christine Hopp @ChristineSHopp]

Bottom line: journal-style formatted pre-prints no good.

[Christine Hopp @ChristineSHopp]

@RIG_Scientist Thank you so much, Rosa! 😊

[Christine Hopp @ChristineSHopp]

@RitaTewari Thank you, Rita!

[Christine Hopp @ChristineSHopp]

The most striking finding was that the presence of CD4 T follicular helper cells induced atypical B cells - which are refractory to many standard stimulation protocols - to differentiate into antibody-secreting cells in vitro.

[Christine Hopp @ChristineSHopp]

Very excited to share this data - now fully peer-reviewed. It’s been wonderful working together with the @MrtcParasito team based in Kalifabougou and the University of Bamako, Mali, as well as #EmoryMedicine and @NIAIDNews. https://t.co/28biDI1vqh

[Christine Hopp @ChristineSHopp]

We characterized Plasmodium- and Influenza-specific B cells and found that atypical B cells share B cell receptor clones with activated and classical memory B cells. Our transcriptomic analysis showed that atypical and activated B cells respond similarly to acute malaria.