Claudia Cantoni

Assistant Professor at #BNI Phoenix. Multiple Sclerosis and myeloid cells maniac.

[Claudia Cantoni @Clodida]

We identify FKBP5 as a key regulator of myeloid-driven neuroinflammation in #MS
🔬 Elevated in CSF monocytes & microglia from MS
🧬 Inhibition boosts myelin clearance & reduces IFNγ signaling
🐭 SAFit2 improves EAE outcomes
#JournalofNeuroinflammation

https://t.co/laQpw8i4WZ

[Satchin Panda @SatchinPanda]

Chronic stress does more than affect mood—it may accelerate biological aging. Persistent glucocorticoid exposure disrupts autophagy, mitochondrial function, and immune resilience, promoting many hallmarks of aging linked to sarcopenia, neurodegeneration, metabolic disease, and frailty. #Aging #StressBiology #Longevity
https://t.co/NdJxWrlII2

[IJMSC @IJMSCtweets]

"We provided a normative ChP volume model, characterized its trajectory across the healthy lifespan, and showed early, consistently higher ChP volume in patients with MS across ages and disease durations in cross-sectional analyses..."
https://t.co/G26cohHMNm
#MultipleSclerosis

[Pluchino lab - Regenerative Neuroimmunology @Pluchinolab]

Expanding roles of cGAS-STING signaling in neuroinflammation

https://t.co/fhQ1gNUu4p

[Waggoner Lab @LabWaggoner]

Review @NatRevImmunol @QuintanaLabHMS
Glial cells in chronic inflammation: diversity, dysfunction and therapeutic targeting
https://t.co/q4k7Q6kbKo

[Nature Rev Immunol @NatRevImmunol]

Senescent B cells accumulate in germinal centre niches of the aged human lymph node https://t.co/k8ER6udjko

[Paul Humphries @PaulHumpa]

Time-restricted feeding extends healthspan in both sexes and lifespan in male C57BL/6 J mice ⁦@CircadianClocks⁩ https://t.co/cQeodpyff1

[Pluchino lab - Regenerative Neuroimmunology @Pluchinolab]

The exercise hormone irisin has neuroprotective effects in a mouse model of multiple sclerosis https://t.co/YdCD9UPhRv

[Ofir Cohn @CohnOfir]

Decades of research have revealed the intricacies of how dendritic cells (DCs) function, but fundamental questions remain about how this group of cells develops in humans and how this process goes awry in disease. A thread on our new work! (1/9)
https://t.co/9hgDt3r8n1

[Annie Marchildon @AnnieMarchildon]

Another paper out of the Harris lab!🎉

Excited to see this work published in Cell Reports, providing important insights and valuable tools for studying microglia in the CNS. Check it out below

https://t.co/p08cyQpNrp

[Satchin Panda @SatchinPanda]

A new Hormone Cell Atlas maps where hormones are made and received across 47 human tissues using 14 million single cells. The resource reveals unexpected hormone-producing cells, endocrine feedback networks, and new insights into metabolic and endocrine disease. #Endocrinology #SingleCell #PrecisionMedicine
https://t.co/eP9lhXMoxg

[TNia @Dr_Tnia]

Astrocyte-microglia crosstalk via CSF1 and IFN-β promotes central nerv... https://t.co/JAJIegivA0

[Nat Rev Neurology @NatRevNeurol]

Neuropsychological symptoms and subclinical disease activity in multiple sclerosis patients receiving high-efficacy therapy https://t.co/RV9b3NhAE0

[Atanas G. Atanasov @_atanas_]

@earthcurated Nature-based interventions were linked to less anxiety, depression and negative affect.

[Agingdoc🩺Dr David Barzilai🔔MD PhD MS MBA DipABLM @agingdoc1]

Safety and efficacy of individualised exercise and NAD+ precursor supplementation in patients with Friedreich's ataxia in the USA: a single-centre, 2 × 2 factorial, randomised controlled trial

https://t.co/1Pll9b0d4q

[Farooqi Lab @Farooqi_Lab]

In a paper just published in @sciencemagazine, we teamed up with @teichlab to construct the most detailed atlas to date of hormone production and action in humans at cellular resolution. (1/8)

Link: https://t.co/5iPOCq9yfu

[Eric Topol @EricTopol]

Important #LongCovid finding of auto-antibodies in patients directed to neural tissue, and then, by transferring the antibodies, recapitulated the disease symptoms in mice @CellCellPress @VirusesImmunity @putrinolab
https://t.co/s4bSXjTVe6

[Diego Clemente's lab @DrDiegoClemente]

📢🧠 New preprint from our group available on @medrxivpreprint.

In this longitudinal study in early untreated RRMS patients, circulating M-MDSCs were associated with immune regulatory dynamics and better relapse recovery.

Congratulations to all authors!

https://t.co/UsfNtbf5gP

[Bruno Ramos-Molina, PhD @Brunorm84]

Western diet-induced #MASH in PWK/PhJ mice identifies disruptions in amino acid and sphingolipid metabolism contributing to cardiac dysfunction @NatureComms https://t.co/oiVJMoCsJq

[Nature Metabolism @NatMetabolism]

#Throwback

REVIEW | E Asimakidou, S Pluchino, B Ambrogina Silva & L Peruzzotti-Jametti

The metabolic engine of cognition: microglia–neuron interactions in health, ageing and disease

https://t.co/10XN4jnJUy

[Waggoner Lab @LabWaggoner]

CD11c+ CD8 T cells cause IFN-γ–dependent autoimmune neuroinflammation that is restrained by PD-1 signaling @JCI_insight
https://t.co/T2vaqZvqfG