Codon Magazine

A newsletter on CRISPR, genetic engineering & the future of humanity. Subscribe and get updates straight to your inbox. By @NikoMcCarty

[Rodrigo Ledesma-Amaro @LedesmaAmaro]

I can finally share our last work on #CRISPR for metabolic engineering just out in @naturecomms
We developed a highly multiplexed, inducible system for simultaneous activation and repression of target genes.
I summarise some key results below (1/6)
https://t.co/gxMSLya2nf

[Codon Magazine @codonmag]

@substack It happened again, a second time, for our newsletter.

[Codon Magazine @codonmag]

Retro Biosciences launches with $180M for anti-aging medicines and anonymous investors. And the #CRISPR patent appeal is already underway.

Synthetic biology updates this week 🔻
https://t.co/Gm4jCGIEuF

[Joa G @GutierrezJoa]

Check out my latest article for @codonmag: synthetic genetic circuits assembled modularly in cooperating communities of yeast! A digest of a recent @eLife paper by Carignano et al. @klavins @seeliglab @RClayWright #paperdigest #scicomm #sciencetwitter https://t.co/xEe8BFFGaM

[Codon Magazine @codonmag]

Yeast cells were programmed to work together using modular, genetic circuits. Those communities behaved according to simple, and predictable, mathematical equations.

https://t.co/h8FdasAKCM

[Codon Magazine @codonmag]

Fibroblast cells are programmed to turn into #heart progenitor cells, simply by bathing them in six small molecules.

#health

https://t.co/wqxzdFHRIG

[Codon Magazine @codonmag]

A new article from @GutierrezJoa describes a modular, plug-and-play approach to engineer coordinating communities of yeast cells.

https://t.co/h8FdasAKCM

[Codon Magazine @codonmag]

Researchers have created artificial cells that can divide their insides into distinct micro-compartments, including a synthetic nucleolus and a "storage" shell (@fabriCELL_UK)

https://t.co/rCbWlx59Pl

[Codon Magazine @codonmag]

Microbes can be engineered to produce custom-designed biomaterials, like cellulose discs that can sense environmental pollutants, or face masks that can detect the #COVID-causing virus. A new review in @NatureMaterials explains.

https://t.co/fxrMvRJrvv

[Codon Magazine @codonmag]

A team from @Yale lay out a new method to discover metabolites, or small molecules, produced by microbes living in the human gut.

https://t.co/npTYXaIPBy

[Codon Magazine @codonmag]

A new study reveals a cleaner, more #eco-friendly way to manufacture glyphosate — the herbicide often sprayed on crops — using engineered, living cells.

https://t.co/h3AblF0Bld

[Codon Magazine @codonmag]

A new review in @NAR_Open highlights the myriad tools available to design guide RNAs for #CRISPR experiments, including some that use #AI.

https://t.co/0Gyzx1BX8I

[Codon Magazine @codonmag]

By modifying the #CRISPR guide RNA, researchers devised a way to correct multiple different single-nucleotide polymorphisms, in human cells, in a single experiment.

https://t.co/F3cR6yG9DQ

[Codon Magazine @codonmag]

A @nanopore sequencer was used to identify possible disease-causing genomic variants in <8 hours for two patients in a hospital. #health

https://t.co/Dk8NDS1bl0

[Codon Magazine @codonmag]

A modified #CRISPR gene-editing tool offers a more efficient way to engineer Arabidopsis plants.

https://t.co/LT0uZBPs8w

[Codon Magazine @codonmag]

The latest issue of @ScienceMagazine reports a complete human genome sequence! Check out the accompanying @naturemethods paper, explaining the computational assembly.

https://t.co/BrAa31C1H6

[Codon Magazine @codonmag]

About 8 percent of the human genome was “missing” from prior sequences. That’s about 200 million base pairs of DNA or roughly the length of an entire chromosome. Those gaps have now been filled in by the #T2T consortium. The latest issue of Codon 👇

https://t.co/5RDfpE1z31

[Codon Magazine @codonmag]

Prime editors are modified proteins that can substitute bases in DNA (like swap a C for a T). A modified version is up to 5000-times more efficient.

Read more in the latest version of Codon.

https://t.co/5RDfpE1z31

[Codon Magazine @codonmag]

Cats have a protein, called Fel d 1, present in their saliva that can cause allergies in people. Researchers at @InBioUS used #CRISPR to knock out the genes encoding Fel d 1 in cells taken from cats.

Read more in the latest issue of Codon.
https://t.co/5RDfpE1z31

[Codon Magazine @codonmag]

About 8 percent of the human genome was “missing” from prior sequences. That’s about 200 million base pairs of DNA or roughly the length of an entire chromosome. Those gaps have now been filled in by the #T2T consortium. Latest issue of Codon 👇

https://t.co/5RDfpE1z31