Constantine Tzouanas

Making every day in lab as unique as every single cell | @shaleklab | Harvard-MIT @mit_hst | @HertzFoundation Fellow | @NSFGRFP Fellow

[Constantine Tzouanas @constantine_sci]

Out today in @CellCellPress! We studied how environmental stresses like high-fat diets today can prime tumorigenesis months to years in the future (1/n)

[Constantine Tzouanas @constantine_sci]

Apply to 2026 yeast display course from @ipiproteins! I did last year's - incredibly knowledgeable and helpful instructors, lovely community, fantastic one-week speedrun to start using yeast display yourself. A very enriching experience 🥁✨

Due Mar 30 https://t.co/ym5hVnFCFY

[Cell @CellCellPress]

The new issue is out! 👉https://t.co/7FRErzTs9T

On the cover, Tzouanas et al. show how environmental stressors like high-fat diets challenge the social contract unifying cellular citizens, pushing some cells to prioritize their own survival over collective community goals.

[Constantine Tzouanas @constantine_sci]

And link to the paper itself https://t.co/VNsHtEoa9O

[Constantine Tzouanas @constantine_sci]

Incredible to see our work on @CellCellPress cover! Environmental stresses like high-fat diets➡️cellular communities whose past histories & present neighbors shape future disease progression & cancer outcomes (with Akira-inspired Easter eggs too!). Appreciation to @TeamSciStories

[Constantine Tzouanas @constantine_sci]

Link to X-planation summary of the paper https://t.co/cU3Tg5Epqm

[Constantine Tzouanas @constantine_sci]

Out today in @CellCellPress! We studied how environmental stresses like high-fat diets today can prime tumorigenesis months to years in the future (1/n)

[Cell @CellCellPress]

Now online! Hepatic adaptation to chronic metabolic stress primes tumorigenesis https://t.co/uNLJ5gLpx2

[Constantine Tzouanas @constantine_sci]

@dpolychr2 @dpolychr2 our paper just was published today and MATCHA is on Github at https://t.co/dCnNsM6ELW - hope it's useful in your work!

[Constantine Tzouanas @constantine_sci]

New preprint! In chronic stress, cells must balance their own survival with tissue-level roles. Prior work has emphasized stress-induced drivers of cell death, but what happens to surviving cells? How do they adapt, and how do their changes connect to long-term dysfunction? (1/n)

[Constantine Tzouanas @constantine_sci]

@dpolychr2 Thanks for the nice words! Not quite yet - had some ducks to get in a row over holidays + while waiting for reviews, but I’ll send you an email/DM once it is!

[Constantine Tzouanas @constantine_sci]

@Bomin_Ku @Bomin_Ku it's been a long time coming, but our paper is finally published and MATCHA is on Github at https://t.co/dCnNsM6ELW - hope it's useful in your work!

[Constantine Tzouanas @constantine_sci]

@Bomin_Ku Appreciate the kind words, and will do!

[Constantine Tzouanas @constantine_sci]

That’s all for now, folks – see here for a link to the paper itself! (fin/n) https://t.co/VNsHtEoHZm

[Constantine Tzouanas @constantine_sci]

Out today in @CellCellPress! We studied how environmental stresses like high-fat diets today can prime tumorigenesis months to years in the future (1/n)

[Constantine Tzouanas @constantine_sci]

Much appreciation & acknowledgement to all involved - co-first authors @drjessicashay @LiverQuant and co-senior authors @WGoessling @ohyilmaz @shaleklab, and many more who enabled this work @MIT_IMES @broadinstitute @kochinstitute @ragoninstitute @harvardmed @BrighamWomens (13/n)