Mario Cordero

Father of one princess, scientist, inflammasomes, aging, 🥋 Taekwondo+Karate in my life

[AthenaBIO 🧬🪩 @athenabiorg]

@CorderoMarioD https://t.co/MEgrf5BqyI

[AthenaBIO 🧬🪩 @athenabiorg]

For most of the body, aging shows up slowly.

For ovaries, the clock can run years ahead, and for women after chemo, decades ahead.

Dr. Mario Cordero's @CorderoMarioD new Science Advances paper is working to protect ovarian reserve before that window closes 👇

[AthenaBIO 🧬🪩 @athenabiorg]

An academic in a small Spanish lab, working on a target two IPO'd longevity biotechs are now circling.

Dr. Mario Cordero @CorderoMarioD chose the harder path: developing it first for women facing menopause after cancer, even though faster applications sit in his pipeline.

Learn more about the science worth backing 👇

[Mario Cordero @CorderoMarioD]

@yusufbuilds1 @LauraMinquini Thank you very much @yusufbuilds1 !!!

[Laura Minquini @LauraMinquini]

I see a lot of people cosplay as underdogs on X while sitting on millions raised from Tier 1 funds.

Want to meet someone who truly is climbing Mount Everest?

Dr. Mario Cordero is looking at an hot target but in an area where more data is needed.

The problem in drug development around sex specific targets is something we don’t talk about enough in biotech.

[Mario Cordero @CorderoMarioD]

@anaelleBHarel @LauraMinquini @athenabiorg Thank you very much, Anaelle, for your nice Report of our work

[TimePie (focus on anti-aging science) @TimePieChina]

NLRP3 haploinsufficiency accelerates #inflammaging, reduces lifespan and impairs metabolic homeostasis in mice by a compensatory NLRP1-NLRP3 interaction, leading to excessive inflammatory activation. #NLRP3
By Inés Muela-Zarzuela,@CorderoMarioD, et al.
https://t.co/TPdYmCqSqK

[Concha Peiró @ConchaPeir]

Just accepted paper! We show how high glucose and cytokines exacerbate innate immune responses in human vascular cells and favor the release of exosomes containing NLRP3 inflammasome components that promote inflammatory senescence in neighbouring cells
https://t.co/HlrP3oRJbz

[Mario Cordero @CorderoMarioD]

@gtimblin @ScienceAdvances Thank you very much Greg, and yes, but this is the next chapter of this tale, It will be out soon!!!

[Mario Cordero @CorderoMarioD]

I am so happy to share this paper from our lab in @ScienceAdvances. NLRP3 haploinsufficiency unmasks a compensatory NLRP1-NLRP3 interaction that drives accelerated aging in micehttps://www.science.org/doi/10.1126/sciadv.aec9499

[AthenaBIO 🧬🪩 @athenabiorg]

Watch the recording of the Menopause Today special 👇

[Mario Cordero @CorderoMarioD]

Un proyecto financiando por @AndaluciaJunta Programa EMERGIA,@AgEInves Programa Consolidación Investigadora y @SaludISCIII programa FIS

[AthenaBIO 🧬🪩 @athenabiorg]

MAJOR NEWS IN OVARIAN HEALTH

Dr. Mario Cordero's @CorderoMarioD just-published @ScienceAdvances paper, broken down.

The surprise: partially inhibiting NLRP3 accelerates aging instead of slowing it. A second inflammasome, NLRP1, surges to compensate. The fix may be dual inhibitors, with big implications for treating Diminished Ovarian Reserve, a condition impacting millions of women.

Science worth rooting for.

Read the full breakdown 👇

[Mario Cordero @CorderoMarioD]

Thank you very much for this big work analyzing our paper in an amazing newsletter

[BIOHBN @BIOHBN]

Check out our latest newsletter on @CorderoMarioD's latest paper in Science Advances: https://t.co/Gc3ap1Am0D

[Victoria Dmitruczyk @tweetatvictoria]

@athenabiorg @CorderoMarioD @ScienceAdvances huge news for inflammation and women's health r&d - mario's paper shows novel insights into how NPRL3 works in humans and why dual inhibitors are important

[Mario Cordero @CorderoMarioD]

A very nice explaining about our last paper in @ScienceAdvances (good idea to make easy to understand papers ) from my good friend @albertosanzmon1. Make some popcorn.

[Alberto Sanz @albertosanzmon1]

The Ageing Paradox of NLRP3 Inhibition https://t.co/zwOF6J4ooY today featuring the work from @CorderoMarioD lab.

[Mario Cordero @CorderoMarioD]

This has been a long and hard way to publish it. Many people and Founders didn't believe in us, too early they said, they didn't want to understand the concept. Too many destructive reviewers 2, but here it is and will be continued. Inflammasomes don´t work alones

[Laura Minquini @LauraMinquini]

Today some AI slop account posted that menopause had been reversed with rapamycin.

Yesterday a researcher got this email.

Tomorrow on our online special Dr. Johnson @JSH_JHNSN will talk about rapa & “Integrated Stress Response” and how it might not be great for ovaries.

[Mario Cordero @CorderoMarioD]

Hi everybody. I'm joining a panel this Friday on whether menopause is something science can actually delay - not just "get through." We'll dig into fertility-extending drugs, ovarian aging, and AI-driven drug discovery with the people doing the work.

[AthenaBIO 🧬🪩 @athenabiorg]

What if menopause wasn't something you just "got through" — but something science could actually delay?

We're talking fertility-extending drugs, ovarian aging, and AI-driven drug discovery with the researchers doing the work.

Join us this Friday at 11 AM PT

Featuring:
🧪 Dr. Mario Cordero — fertility-extending drug research (paper dropping in Science Advances this week) @CorderoMarioD

🧬 Dr. Joshua Johnson — ovarian aging, featured in TIME @JSH_JHNSN

🤖 Gero's Head of Translational AI @hacking_aging

📊 Cremieux (Genetics/Data) @cremieuxrecueil

All in one room. Free. Online.

SIGN UP [link]👇

[AthenaBIO 🧬🪩 @athenabiorg]

📣Announcing MENOPAUSE TODAY - a bio deep dive special sparked by @Grimezsz request to save the ovaries!

Drugs to extend fertility @CorderoMarioD
Rapamycin @JSH_JHNSN
AI & Drug Discovery @hacking_aging
Ovarian cryopreservation
Data @cremieuxrecueil

And more!

📆 Date: Friday, June 26th
⏰ Time: 11:00 AM PT / 2:00 PM ET / 8:00 PM CET
📍 Location: Online
Co-hosts: @LauraMinquini @agingroy @BIOHBN

Link in reply 👇