Mathilde 🕊

Ouverte à tous les mouvements de pensée mais intolérante à ceux qui tolèrent le pire.

Ni gauchiste, ni droitarde, pro-intelligence

[Shehan @TheCryptoCPA]

"Renting is throwing money away" hits different when you've just handed a roofer $18,000 on a Tuesday. Ownership has costs that never appear in the mortgage vs. rent comparison. Run the full numbers before picking a side.

[Afshine Emrani MD FACC @afshineemrani]

I'm a cardiologist. Everyone is sharing this study as a skin story. They're burying the part that matters.
Scientists took the aorta of a 75-year-old donor, applied a single engineered enzyme, and stripped away more than 70% of the molecular damage — bringing it down to the levels you'd see in a 30-year-old artery.
Published five days ago in Nature Communications. Revel Pharmaceuticals, with Calico and the University of Colorado.
Here's what they erased.
Sugar reacts with proteins in your body the same way heat browns bread — slowly, over a lifetime. It leaves behind a residue called CML, the most abundant advanced glycation end product in aging tissue. It welds itself onto collagen and elastin in your skin, your eye lens, and your arterial walls.
Two things follow. Your arteries stiffen. And CML latches onto a receptor called RAGE, which drives chronic inflammation — the exact fire I've been writing about for months as the engine of heart disease.
Since the 1980s this damage was considered permanent. Your body has no enzyme to remove it. Every existing approach only slows new damage from forming. Nothing touched what was already there.
So they built an enzyme that doesn't exist in nature. They screened 45,000 protein structures, then ran five rounds of directed evolution across more than 500 million variants until they had CMLase — a molecular lawnmower that oxidizes the CML off the protein and restores the original, healthy lysine underneath.
Not patched. Reversed.
Over 70% cleared from elderly arterial tissue. Over 55% from elderly skin — below the levels found in 31-year-old skin. 45-78% in lens proteins. The CEO said they expected 20% and were floored.
Arterial stiffness drives systolic hypertension, heart failure, and stroke, and I have no drug that reverses it. I can slow the process. I cannot undo it. This paper says undoing it may be possible.
The caveats are real and I won't skip them. This was done on donated tissue in a dish, not in a living person. No functional data yet — we don't know if that artery got measurably more elastic. Delivering a large enzyme deep into human tissue is a hard, unsolved problem. Clinical trials are years away.
But something considered permanent for forty years just came off human tissue.
We spent a century learning to slow aging. Someone finally figured out how to erase it.
Thank you @theallinpod @friedberg @chamath @pesottas

[EDOSE✨ @iam_biglad1]

Reality check : The middle class is gone.
We should be living comfortably at $100k . Instead, we were better off at $50k in 2008. That says everything.

[Dr Singularity @Dr_Singularity]

We will cure aging soon

[Ethan UTD @UTD_EH]

Referee…. Come on !?

#ESPARG #FIFAWorldCup #WorldCupFinal https://t.co/RsFAXFdRwf

[Lord Roly 🇨🇮 @ZaynRoly]

Tout ça pour prendre un rouge en final 😂😂

#ESPARG

[Abdellah Boulma @AbdellahBoulma]

L’Espagne est championne du monde. Le football respire. Le monde aussi #ESPARG

[lélé ❤️💙 @Julien_27LS]

#ESPARG
Bonne nuit Enzo 😂😂😂😂😂😂😂😂 https://t.co/BwhwSW7eQY

[lélé ❤️💙 @Julien_27LS]

#ESPARG
Mon seul souhait aujourd’hui, c’est de voir des larmes de tristesse sur son visage après avoir perdu la CDM !

[Elz UTD @elz_utd]

imagine t'es l'Argentine de Messi et t'as 0 tirs, cartons jaunes et 1 rouge, t'as fait+ de 19 fautes en 120mn de jeu.
l'Espagne c'est tellement la meilleure équipe de ce tournoi.
#ESPARG

[DogeDesigner @cb_doge]

You don’t realize it yet
but Optimus will change everything.

[Claradrôle 🥱 @Clar_roche]

Je suis en train de regarder un reportage sur les camping et genre y a vraiment des gens qui payent 700 (SEPT CENT)€ pour passer 1 semaine dans une tente ?? Pitié mais jurez moi de toujours voyager à l’étranger pour m’épargner cette arnaque

[DogeDesigner @cb_doge]

A Tesla owner slept overnight in his Model X Plaid during a brutal 40°C heat wave in Austria. The car kept the cabin at 20°C for 8 hours and used only 12% battery.

Camp Mode is one of Tesla’s most underrated features.

[𝒢𝒾𝓁𝒷ℯ𝓇𝓉 @AbakpaJob]

a 9-5 job means you live at work and visit your house at night

[David Sinclair @davidasinclair]

Aging is controlled by single genes
Aging is slowed by adversity
Aging regulators can be modulated by small molecules
Aging is slowed by eating stressed plants
Aging is largely epigenetic noise
Cellular damage accelerates epigenetic age
Aging is a disease
Aging is reversible

[beIN SPORTS @beinsports_FR]

6-4 ! Quel match de fou entre la France et l'Angleterre !
Les Three Lions menaient 4-0 à la mi-temps, les Bleus sont revenus à 4-3 mais s'inclinent finalement 6-4.

[Bryan Johnson @bryan_johnson]

@MrBeast I'll take the billion and solve aging.

[Hannah @dumbandfunn]

hot summer nights, mid July

[‏ً @omgsidewalks]

It’s very craży that 70-80 year olds are generally seen as unemployable due to physical and mental decline BUT we're allowing them to run our ENTIRE country.