Shan Chong

Advancing public sector biomedical research @ASTARsg | Previously @MRC_LMB @sangerinstitute

[nature @Nature]

Nature research paper: A brain-to-gut signal controls intestinal fat absorption https://t.co/cxVIXgAWwN

[Biomedical Picture of the Day BPoD @BPoD_s]

Fruit fly eye study uncovers molecular pathways shaping cells' undersides (basal) as tissues develop

📷 : Rhian F. Walther et al @PichaudLab @LMCB_UCL in @PLOSBiology
➡️ : https://t.co/Q7mDxR3fRg

[CRISPRpapers @CRISPR_papers]

A modular strategy for extracellular vesicle-mediated CRISPR-Cas9 delivery through aptamer-based loading and UV-activated cargo release https://t.co/8xf6SA8Wnb

[Arc Institute @arcinstitute]

@hsiung_chris in the Gilbert Lab has developed an Acidaminococcus Cas12a variant that can knock down 3+ loci simultaneously – meaning researchers can study complex genetic interactions and map regulatory biology more effectively.

Check it out: https://t.co/KhRlmWWAlQ

[Shan Chong @czshan]

Attended #SynBioBeta for the first time this year and was impressed by the enthusiasm at changing the world with biology. Sharing my top 3 takeaways in the link below #AI #synbio #biomanufacturing #bioeconomy https://t.co/Wg8eIp60ud

[Shan Chong @czshan]

6 years after we published the first CRISPRa screening platform for receptor-ligand interactions, another group has come up with an approach which greatly improves robustness and sensitivity of such screens! :) https://t.co/jDezwC9gee

[allen institute @AllenInstitute]

We've joined Weill Neurohub, a research network advancing treatments for neurological diseases. The partnership will integrate our robust brain mapping and recording with research at @UCBerkeley, @UCSF, and @UW.

More about the partnership: https://t.co/oyzvXTj51L

#OpenScience

[Valentine Svensson @vallens]

Single-cell metadata as language - https://t.co/JeGSJvVAU2

[Nature Biotechnology @NatureBiotech]

Machine learning for functional protein design https://t.co/ZgfK6N0LD7

[biohub @biohub]

✅ Genomes sequenced
✅ Protein structures solved
❓Physiology of cells in organ systems
Cell biology has made huge leaps in the past few decades.

Our Head of Science @StephenQuake explains how AI will help us gain new insights into how cells work https://t.co/9AmOEEfnsj

[Gray Camp @GrayCampLab]

36 datasets, 26 protocols, 1.7 million harmonized cells! First edition Human Neural Organoid Cell Atlas. Important work from @zhisong_he @josch_f Leander Dony @TreutleinLab @fabian_theis. Strong community effort @Sergiu_P_Pasca @GiorgiaQuadrato. #organoids @ETH_BSSE @IHB_Research

[Shan Chong @czshan]

... due to the associated disappointment. Without collecting this data I would have continued to believe that selecting the ‘Priority Pickup’ option wouldn’t make a difference."

[Shan Chong @czshan]

How data can illuminate even simple biases in our everyday life! A fun example looking at Lyft's priority pickup option.

[Valentine Svensson @vallens]

Lyft priority pickup waiting times - https://t.co/8O857covYg

[Shan Chong @czshan]

"It turns out my impression of the ‘Priority Pickup’ option not improving waiting times was wrong. [...] My original impression is a very common cognitive bias, where the rides that took longer to arrive than I had paid for were more memorable...

[Clement Chow @ClementYChow]

Science and medicine can help you eat bacon again. I can’t think of better reason to keep supporting science

[Rothstein Lab @Rothstein_Lab]

Targeting AAV vectors to the central nervous system by engineering capsid–receptor interactions that enable crossing of the blood–brain barrier https://t.co/MEARuZ4gaw

[Shan Chong @czshan]

Cell-cell communication continues to be a fascinating topic : )

[Peng Jiang Lab @LabJiang]

This study also provides crucial insights into the selection of factors for inducing astroglial differentiation from human pluripotent stem cells.

Identification of ligand–receptor pairs that drive human astrocyte development
https://t.co/UTG8oW6FeR

[Shan Chong @czshan]

@Dr_FelixChan @jdpereira I second this comment and can help link up to the right people if needed : )

[Shan Chong @czshan]

Great work by @Peiyu_Xu_ from @zhangf lab on the characterisation of the first eukaryotic RNA-guided endonuclease system. Our knowledge of gene editors has moved so much since the days of CRISPR/Cas.

[Peiyu Xu @Peiyu_Xu_]

Thrilled to share my first postdoc paper in ⁦@Nature⁩! We present a new RNA-guided system, Fanzor.

Heartfelt thanks to ⁦@zhangf⁩ , Makoto, & team ⁦@broadinstitute⁩, and cryo-EM facilities ⁦@nyulangone⁩ and ⁦@mit_nano⁩. https://t.co/L0UrjPAHeW

[Shan Chong @czshan]

People are an important resource, esp for creative professions like research. I think it's important for any organisation leverage the unique competencies of its people whilst also maintaining some level of top-down strategic direction. Ideally should a two way conversation...

[Alex Telford @Atelfo]

Dr. Paul Janssen, the founder of Janssen pharmaceutica (now J&J), was one of the most prolific drug discovery scientists ever. Between 1953-1991 Janssen and his team discovered >70 new medicines.

I enjoyed this paper about his R&D philosophy: https://t.co/lTCZjCO2l9