DeniseJeridi

[Ali Max Erturk @erturklab]

Today in @Nature, we report MouseMapper: foundation-model AI to map disease perturbations across the entire mouse body cell-by-cell.
In obesity, it revealed body-wide inflammation & unexpected facial nerve damage. 🧵👇🔉
https://t.co/BERf5GQ10Z led by @Dorie00 & @yingchen733

[Ali Max Erturk @erturklab]

Most transcriptomics studies sample ~0.001% of a mouse. Which region to choose? Often we guess.

We introduce DISCO-seq🤗flipping the order:
Whole-body 3D imaging with RNA-preserving clearing→ pick ROIs in 3D→ unbiased scRNAseq
Led by @HarsharanBhatia
https://t.co/kYkzAWC5K9

[Ali Max Erturk @erturklab]

We are introducing LipiGo 🤗
A programmable DNA–lipid nanocarrier 🧬 with built-in targeting logic.
It de-targets the liver and redirects mRNA delivery into lymphoid organs, enhancing therapies requiring the immune system. by @cerenkimna @kalorintschi https://t.co/moldTeozmj
1/n

[Doris Kaltenecker @Dorie00]

Amazed to share our new study published in @CellCellPress revealing how the liver contributes to weight loss in cancer via disruption of a circadian regulator and secretion of catabolic factors.

Big thanks to @FiskerSchmidt, S. Herzig, @BerrielDiaz
🧵👇

https://t.co/2fvK9ExTMO

[DeniseJeridi @d_jeridi]

RT @erturklab: See our recent @NatureBiotech study SCP-Nano in flow! Mapping LNPs, AAVs, and DNA nanostructures to track targeting & unseen…

[Ali Max Erturk @erturklab]

LNP/mRNA therapeutics and AAV-based approaches require cell-level precision to achieve success without significant toxicity to other cells. To enable this, we now introduce SCP-Nano🤗 in @NatureBiotech: an AI-based technology for precision nanotechnology. https://t.co/1YniGZr4O4

[Helmholtz Munich | @HelmholtzMunich @HelmholtzMunich]

SCP-Nano: Advancing Precision Medicine with Nanocarrier Visualization

How can life-saving therapies reach their target cells without harmful side effects?
👉https://t.co/ptSiFh5AU7

💡Researchers at #HelmholtzMunich, @LMU_Muenchen, and @TU_Muenchen have developed SCP-Nano (Single-Cell Profiling of Nanocarriers): The new technology visualizes nanocarriers in the entire mouse body at a single-cell level.

🔬 This innovation combines advanced imaging and #AI to detect even ultra-low doses of nanocarriers like lipid nanoparticles, DNA origami, and AAVs.
SCP-Nano paves the way for safer and more effective mRNA vaccines, gene therapies, and beyond.

🌟Why it matters: SCP-Nano ensures therapies are delivered to the right cells while identifying harmful off-target effects - driving the future of personalized medicine and precision drug development.

@erturklab @jieluo692
@SyNergy_Cluster @NatureBiotech #Nanotechnology #PrecisionMedicine #DrugDevelopment #AIinHealthcare #mRNATherapies #GeneTherapy #PersonalizedMedicine

[Eric Topol @EricTopol]

The #SARSCoV2 spike protein can persist in the brain—skull bone marrow and meninges—to induce neurologic damage https://t.co/FtsftML1m4 just published @cellhostmicrobe @erturklab open-access

[Ali Max Erturk @erturklab]

Our new study shows that SARS-CoV-2 spike protein accumulates & persists in the body for years after infection, especially in the skull-meninges-brain axis, potentially driving long COVID. mRNA vaccines help but cannot stop it🔬🧠🦠🧵👇@cellhostmicrobe https://t.co/IEGx7HIrXf

[Ali Max Erturk @erturklab]

Humbled and deeply honored to be named a Life Sciences winner for #FallingWalls #ScienceBreakthrough 2024!
Excited to present our work on 'Breaking the Wall of Animal Research with AI' at #ScienceSummit24 in Berlin.
This award is a testament to the incredible efforts of my amazing team and the transformative potential of AI in shaping the future of science and biomedicine. #GlobalCall24.
Grateful to @falling_walls for this recognition.

[Ali Max Erturk @erturklab]

Imagine seeing a disease's impact on every cell in the body. Now, you can!
We introduce MouseMapper, an AI tool to reveal system-wide disease perturbations. MouseMapper showed obesity-induced changes in facial nerves & body-wide inflammation 👉🏼🧵https://t.co/2sPQra70xx

[Ali Max Erturk @erturklab]

Discover the future of 3D-omics! Our perspective aritcle explores how tissue clearing and AI with single-cell omics could revolutionize understanding of entire organs & organisms. Read the full article: https://t.co/OohxFmYnyZ

[Ali Max Erturk @erturklab]

What if we could map every cell in the body, revealing its location and molecular identity? In this @NatureMethods perspective, we discuss the new era of 3D-omics by tissue clearing and AI, called Deep 3D Histology: https://t.co/iXRJ5GrpV3 PDF: https://t.co/fiR3wBonDe 🧵👇🏼

[Nature Methods @naturemethods]

The July issue is live today! https://t.co/WkJdk9BPCS

The beautiful cover comes from the @erturklab and shows c-Fos+ neuronal mapping in whole mouse brains.

See paper: https://t.co/dOaFfRzyLj

[Nature Biotechnology @NatureBiotech]

DELiVR, is a deep-learning pipeline for whole-brain cell mapping, which is trained on reference annotations generated in a virtual reality environment. https://t.co/rhx5iOKAhZ #NBThighlight

[Ali Max Erturk @erturklab]

Very excited to share that our DELiVR method is now open access published @NatureMethods. We created a simple, brain-wide cell analysis deep learning tool, no coding needed! Fiji Plugin makes it accessible to all. https://t.co/qjFk3p5aba
by @Dorie00 @Rami96614090 @moritz_negwer

[Nature Biotechnology @NatureBiotech]

The April issue is live https://t.co/wVzwnybjTU

Our cover shows an image of a whole mouse body with depth color-coding of a neuronal marker. Mai et al. present wildDISCO, a method for whole-body imaging compatible with standard IgG antibody labeling https://t.co/POOiYZVyGS

[Ali Max Erturk @erturklab]

🌟 End-of-Year Opportunity 🌟
Looking forward to your next career move? Join our vibrant teams!
We have multiple openings for PhDs, Postdocs, & Staff Scientists at our academic labs & startups.
👉 Apply now / share:
https://t.co/Bva9JURhgR
https://t.co/nzJeyq4wMH @DeepPiction

[DeniseJeridi @d_jeridi]

Great opportunity to join a diverse and interesting team!

[Ali Max Erturk @erturklab]

🔬🌟 Join our Innovative Team at @HelmholtzMunich!

We're excited to announce an opening for a Staff Scientist in Tissue Clearing & Image Analysis at our lab. Be part of a team that's pushing boundaries in bioengineering, AI, and more!

We are at the forefront of combining biology, chemistry, engineering, and computer science. We specialize in developing advanced cellular imaging technologies and deep learning algorithms for analyzing large data. We aim to develop treatments for complex diseases including Alzheimer’s disease and cancer by accelerating scientific discoveries with this unique technologies and approach.

Your Role:

Maintain advanced light-sheet microscopes
Implement tissue-clearing projects and collaborations
Support in data analysis and infrastructure

We're looking for:

Passionate individuals with a background in Life Sciences, Optical Physics, or similar fields
Experience in tissue clearing, fluorescence microscopy, and image analysis automation
Fluency in scientific English.

Why Helmholtz Munich?

· We value diversity and inclusivity, believing it drives innovative research
· We offer a dynamic work environment, health promotions, and personal development opportunities
· Flexible working hours and comprehensive benefits

Interested in making a meaningful impact in health research? Contact us for more details and join our diverse team committed to excellence and innovation!

Apply now: https://t.co/oyitRPsQgZ

#ScienceCareers #BiotechJobs #DiversityInSTEM #Innovation #MunichJobs #DISCO #Clearing #AI #imaging #deeplearning

[Ali Max Erturk @erturklab]

Excited to explain some more details of our recent wildDISCO @NatureBiotech work 🤗