deadpan science

[deadpan science @deadpanscience]

@CMMGinc @hasanthehun what do you think?

[deadpan science @deadpanscience]

@HannesStaerk @Xaira_Thera You’re not wrong, but honestly making a big deal about these observations just shows how much of a gap there is in knowledge from denovo designers and actual wet lab scientists with domain knowledge.

[deadpan science @deadpanscience]

@mattunc2003 @Polymarket Consider this was 80+ years ago from a sitting democratic president: https://t.co/3GKeMrJrmM does it make you reconsider that cartoon?

[deadpan science @deadpanscience]

@yo_arfi Just use one of these: https://t.co/to8h1MnM7P

[deadpan science @deadpanscience]

@JacobMolBio Cool, did any of them actually bind?

[deadpan science @deadpanscience]

@iskander It is still very difficult, and the adaptyv binder contests prove it

[deadpan science @deadpanscience]

@DanielleFong Somebody order some primers sheesh

[deadpan science @deadpanscience]

@FishTanksSuck @CoronaHeadsUp There are citations in the linked statement to peer reviewed articles.

[deadpan science @deadpanscience]

@Notmeplssssss @cushbomb https://t.co/aRoiP9kHWj

[deadpan science @deadpanscience]

@MathSRIsh Or really anything at a 10mL-20L volume

[deadpan science @deadpanscience]

@FoxNews Calling @jjreeves you know what video you need to do

[deadpan science @deadpanscience]

@DdelAlamo @RolandDunbrack It’s not everything sucks

[deadpan science @deadpanscience]

@boni_tobi @NikoMcCarty Here you go: https://t.co/MIElhTTPBk

[deadpan science @deadpanscience]

@AntounNabhan Tell me you haven't tried bio with Wuxi without telling me you haven't tried bio with wuxi

[deadpan science @deadpanscience]

@jrkelly 97-99% of things that come out of proteinmpnn sol are soluble. This doesn’t solve a problem

[deadpan science @deadpanscience]

@nanogenomic Let us know when you have the binding results. And the PK results.

[deadpan science @deadpanscience]

@gklambauer Did they really publish this without comparing the physics and boltz predictions to actual wet lab results?

[deadpan science @deadpanscience]

@josiezayner Do any of them actually work? If not then no

[deadpan science @deadpanscience]

@design_proteins Affinity characterization is solved, but each peptide still costs ~$300-200 to make if you chemically synthesize. Half that if you make it as a protein fusion

[deadpan science @deadpanscience]

@SandyBrandyy @pranamanam @Ligandal Great question- what metrics would you use for this? Probably real world wet lab validation of binding at a minimum, the best affinities? If you didn’t get those data from a cro then your model is probably not best in class and it also demonstrates you have an unserious team.