Phil Leung

Co-founder @Xaira_Thera | @UWProteinDesign PhD

[Phil Leung @definitelyphil]

My doctoral advisor @UWMolES / @UWproteindesign (and current scientific advisory board membe @Xaira_Thera) David Baker won the nobel prize!! So stoked and extremely determined to deliver on the promise of this tech! https://t.co/jWl7ExL9uy

[Phil Leung @definitelyphil]

Glad to see our antibody design paper finally out in @Nature (and congrats to lead authors and everyone involved )!
At @Xaira_Thera we are excited about pushing antibody design further to bind harder targets and make drugs for unmet medical needs.
Paper:
https://t.co/h2bXGOvuGW

[Phil Leung @definitelyphil]

Congrats @adam_broerman @FloPraetorius @UWproteindesign and team!

[Phil Leung @definitelyphil]

Showcase of #proteindesign possibilities+why they matter!
- minibinders (rigid fusions; composability with other denovo designs)
- tunable biophysical properties (modulate k_off, flexibility, strain)
- #crispyshifty hinges (allosteric control of binding kinetics to native target)

[Adam Broerman @adam_broerman]

We sought to make proteins both potent and FAST. We used #proteindesign to design precise control over protein interaction lifetimes, enabling us to construct rapid-response circuits, biosensors, and switchable cytokines. Now published @Nature! Links to paper and tutorial below.

[Jeff Nivala @jeffnivala]

We searched for Bigfoot using CRISPR. DNA storage meets CRISPR search: AI maps the data, Cas9 slices it, nanopores read it. Multiplexed molecular search with semantic retrieval across a database of DNA-encoded images. Off-targets = a feature, not a bug. https://t.co/l7FLfxnBPL

[Susana Vazquez Torres @SusanaVazTor]

Thrilled to share our latest publication in Nature: https://t.co/GDbQL0fUIO. This work reflects a fantastic collaboration—special thanks to David Baker and @TimothyPJenkins. Hoping it sparks attention to this neglected health issue and drives solutions in the years ahead!

[Phil Leung @definitelyphil]

Bonus Flo reunion pic! @FloPraetorius

[Phil Leung @definitelyphil]

What an immense privilege to celebrate the #NobelPrize with David, former colleagues from @UWproteindesign , current colleagues at @Xaira_Thera and @RosettaCommons family!

[Phil Leung @definitelyphil]

So cool to see #CrispyShifty hinges applied this way! Congrats @adam_broerman

[Adam Broerman @adam_broerman]

Excited to announce our new #proteindesign strategy for allosterically controlling the kinetics of protein-protein interactions! Read on for cool applications in cytokine signaling, biosensing, and protein circuits. https://t.co/jBIHq10Ykd

[Adam Broerman @adam_broerman]

Excited to announce our new #proteindesign strategy for allosterically controlling the kinetics of protein-protein interactions! Read on for cool applications in cytokine signaling, biosensing, and protein circuits. https://t.co/jBIHq10Ykd

[Sergey Ovchinnikov @sokrypton]

I guess errors are expected. But it does highlight the need for journals to require depositing source code before publication.

[David Juergens @DaveJuergens]

⚛️ I got a new job ⚛️

After 5 wonderful years at @UWproteindesign and @UWMolES, I’m headed to Palo Alto for a postdoc at @StanfordUChem under Todd Martinez.

SUPER excited to dive into deep learning for quantum chemistry and explore the Bay Area!!

[Institute for Protein Design @UWproteindesign]

Nobel Laureate David Baker on the phone with fellow awardees Demis Hassabis and John Jumper. The trio discussed how their teams have inspired one another and what the future may hold.

[Phil Leung @definitelyphil]

#CrispyShifty proteins mentioned - highlight of the announcement for me 😁 @ArvindSPillai1 @FloPraetorius

[Phil Leung @definitelyphil]

My doctoral advisor @UWMolES / @UWproteindesign (and current scientific advisory board membe @Xaira_Thera) David Baker won the nobel prize!! So stoked and extremely determined to deliver on the promise of this tech! https://t.co/jWl7ExL9uy

[Phil Leung @definitelyphil]

Congrats!!

[Jeff Nivala @jeffnivala]

Published today in @Nature, we describe an approach for single-molecule protein reading on @nanopore arrays. By utilizing ClpX unfoldase to ratchet proteins through a CsgG nanopore, we achieved single-amino-acid sensitivity. https://t.co/ZTFNZkwpcj

[Phil Leung @definitelyphil]

@pranamanam Sure, structure prediction for IDRs is not well posed. That's not the original point you were making though 😅

[Phil Leung @definitelyphil]

@pranamanam FRET, DEER, EM and x-ray crystallography of the two states: https://t.co/hno657zfun

[Phil Leung @definitelyphil]

@DdelAlamo @srivsesh @anthonygitter @KevinKaichuang @pranamanam @DaveJuergens @sokrypton @avapamini @json_yim @amyxlu @rohitsingh8080 @proteinrosh @JustasDauparas @thisismadani @HannesStaerk Did anyone grab the original tweet? I can't see it and I'm dying of curiosity

[Phil Leung @definitelyphil]

Love this article by @schubertcm @geekwire on what we're trying to do here in #Seattle at @Xaira_Thera @JustasDauparas @naterbennett0 https://t.co/Q7YmXEBtMn