Florian Praetorius

Biomolecular designer; currently postdoc @UWproteindesign; starting my lab @ISTAustria in March 2024
@flopraetorius.bsky.social

[Florian Praetorius @FloPraetorius]

Exciting news part 2: I’m honored and delighted to announce that the Praetorius lab for Biomolecular Design @ISTAustria has been awarded an #ERCStG (before even starting) for “Design of Nucleic Acid-templated Ordered Protein Assemblies”. @ERC_Research

[Kiera Sumida @KieraSumida]

Anna and Sam are X-less but they’ve done some excellent work with this project. It’s a very exciting time for enzyme designers!

[Sri Kosuri @srikosuri]

It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS, indeterminate dendritic cell histiocytosis or other (non-LCH) histiocytic sarcomas cases.

I'm trying to understand non-surgical chemo and targeted therapy options, new pathology markers to better diagnose subtypes/treatments, and any data on progression in pediatric patients. Please feel free to share – I’m trying to cast a wide net due to the rarity of this condition and how little is known.

People can contact me directly at my first name (as written in my profile) at https://t.co/ubo0zQRMn0.

[The Nobel Prize @NobelPrize]

“Science is a human activity.”

The week before chemistry laureate David Baker visited Stockholm to receive his Nobel Prize, his 101st PhD student had just graduated from his lab. For Baker, doing great science is about collaboration – he puts great effort into fostering a diverse, vibrant and sociable community of scientists that he works with. One hundred and thirty of those students and researchers joined him in Stockholm – perhaps the ultimate lab celebration!

More about Baker and the 2024 Nobel Prize in Chemistry: https://t.co/uOwBYCZDq6

[Christopher Frank @chrisfrank662]

After showing that AF2 can be used to design very large proteins by performing #RSO, I am happy to share another fun project we did: the #af2cycler @sokrypton @hendrik_dietz
https://t.co/xMSVFH7oF1

[Adam Broerman @adam_broerman]

Excited to announce our new #proteindesign strategy for allosterically controlling the kinetics of protein-protein interactions! Read on for cool applications in cytokine signaling, biosensing, and protein circuits. https://t.co/jBIHq10Ykd

[Florian Praetorius @FloPraetorius]

@adam_broerman This project builds on our previous work on protein switches, switchable assemblies, and exchanging protein assemblies:

https://t.co/75ml4dqN07

https://t.co/cnzTvQ2vCe

https://t.co/1GTSEzxSLp

[Florian Praetorius @FloPraetorius]

I'm thrilled to share @adam_broerman's preprint @UWproteindesign about facilitated dissociation in designed proteins. In his designs, a competitor can actively displace a tightly bound partner, speeding up dissociation by several orders of magnitude.

https://t.co/7dI9FvHnIS

[Florian Praetorius @FloPraetorius]

I'm very proud of this work, but I'm even prouder of the amazing scientist @adam_broerman has become in the course of this project!

[Christopher Frank @chrisfrank662]

Finally, out in @ScienceMagazine today, our work on de novo protein design. Together with @HattoriLab , @sokrypton & @hendrik_dietz we showed how we can drastically improve AF2 based hallucination, surpassing, or reaching SOTA diffusion models
https://t.co/VSbKR3JQLS

[Gustav Oberdorfer @GustavOberdorf1]

So delighted to have this finally online!
In our newest preprint we are detailing the computational design of a catalytically active helical barrel protein with a highly engineerable central channel. Check it out!
https://t.co/Bx7nC2wMto

[Florian Praetorius @FloPraetorius]

@definitelyphil @ArvindSPillai1 this one?

[Lukas Milles @LFMilles]

Excited to join the Gene Center at LMU @GeneCenter_LMU @LMU_Muenchen as a professor, looking forward to design some cool and unusual de novo proteins here!

[Michael Bronstein @mmbronstein]

I am looking for a partner in crime who actually understands biology in Vienna — join Aithyra to make some magic

https://t.co/XV6p6g4TDU

[King Lab @KingLabIPD]

#MERS vaccines built on our two-component protein nanoparticle platform induce robust neutralizing antibody responses and protect mice against vaccine-matched challenge.

This collaborative project was led by @chao_cara and is out now on @biorxivpreprint: https://t.co/aHgx6tYZbu

[Florian Praetorius @FloPraetorius]

@ferruz_noelia Congratulations @ferruz_noelia !