Congratulations to Holly Gildea on acceptance of her thesis work in Science Advances! A preprint of her work describing how glial cells coordinate the heat shock response can be found on BioRxiv here:
https://t.co/wMPDbiTzPz
We find that the mtUPR also increases import that may help all these great proteins get in and save the organelle. This increased mitochondrial import is also essential for lifespan extension. If you are curious about mitochondria and longevity - this paper is for you!
Check out our newest pub in JCB! https://t.co/Fyrkr0OT6C
Decreased mitochondrial import from stress activates mtUPR, but then how do all those mitochondrial-saving expressed genes get back in? (1/2)
Huge congratulations to @tayladhunter on a well deserved Goldwater Scholarship! Tayla did a fantastic job in our lab this past summer working with @holly_gildea. Any MD/PhD program would be lucky to have her!
Congratulations to @tayladhunter who has been awarded the Goldwater Scholarship! The Goldwater honors outstanding undergrads pursuing research science. If you're recruiting for MD/PhD programs, take note!! Big things coming her way 🎉🥳
Excited to share our new paper! We found that aged mice exhibited an exaggerated UPRER signature - lipid and protein synthesis overall were more suppressed, however, canonical UPRER proteins were translated at higher rates in aged mice under ER stress.
https://t.co/RYmw3MkuRs
Hi Twitter! The Dillin lab is hiring a senior mouse technician to manage our mouse colony and assist with experiments in our studies of aging and stress response. Feel free to share this with anyone who you may think is interested! https://t.co/e4wsznfa9b
And another preprint from @dillinlab@philfrankino@holly_gildea showing that overexpression of hsf-1 in only the 4 glial cells of #Celegans is enough to induce a heat shock response and longevity 9/7 https://t.co/iFviCiyWkO
Another preprint from our lab is up now. In this one, @philfrankino et al. found and characterized a role for SKN-1 as a surveillance factor. Turns out it can monitor and respond to genetic perturbation of amino acid catabolism pathways and alter multiple stress resistances!