Dirk Paul

Integrative Genomics, Precision Medicine, Chronic Diseases, Drug Discovery @AstraZeneca @Cambridge_Uni | Parkrunner | Views my own

[BHF Cardiovascular Epidemiology Unit at Cambridge @CAMBRIDGE_CEU]

From @sangerinstitute and the CEU!

Translating genetic changes into future health impact

New resource helps bridge the gap between identifying genetic changes linked to health conditions & understanding how these changes impact biological processes

🔗https://t.co/6HP1N0lA8R

[YouGov @YouGov]

Five years on, few Britons think Brexit has been good for anything

% saying Brexit has had a positive impact on...
Control the UK has over its laws: 31%
UK's ability to respond to COVID-19: 23%
British politics: 12%
UK's level of international trade: 11%
British businesses: 11%
UK diplomatic influence in the wider world: 10%
National security: 10%
The economy: 10%
Yourself personally: 8%
Public finances: 8%
Strength of the Union: 7%
NHS: 6%
Tourism from Europe > UK: 6%
UK diplomatic influence in Europe: 6%
Immigration levels: 6%
Tourism for Britons > Europe: 5%
Cost of living: 5%
Crime: 4%

https://t.co/G8tgUQYw1u

[Satoshi Yoshiji @SatoshiYoshiji]

📣Excited to share our paper in @NatureGenet!
https://t.co/jUbE3DtK60

Do plasma proteins mediate obesity’s effect on CAD risk?
→Using two-step proteome-wide MR, domain-aware MR, epigenomics & scRNA-seq, we prioritized endotrophin as a mediator & potential therapeutic target
A 🧵

[UK Biobank @uk_biobank]

Today we’re launching the world’s most comprehensive study of proteins circulating in our bodies, which will transform research into new medical tests, drugs and treatments.

Discover more: https://t.co/o8t2yuknLv

[Parody Ken Clarke @MrKennethClarke]

If you’re thinking about voting Reform, remember that they made you poorer.

[NIHR BTRU in Donor Health and Behaviour @DonorHealthBTRU]

Can genetics affect our iron levels and what impact can this have on our health?

@eliasallara and colleagues explored how the body controls iron and highlight how having too much or too little can negatively impact health

Read more here 👉 https://t.co/BtKzB2wi5M

[NIHR BioResource @NIHRBioResource]

Dr. @dirk_paul's study on cell type-specific roles in cardiovascular disease highlights the critical insights made possible by us.

Find out about more researcher stories and our involvement: https://t.co/Y5qmWZTxBg

[Dirk Paul @dirk_paul]

@ee_davenport @TVanderstichele @nickywhiffin @ewanbirney @LeopoldParts Congratulations, Thomas! 🎉🤩 Well done!!!

[FinnGen @FinnGen_FI]

Million Veteran Program & FinnGen teams are pleased to release v1 meta-analysis of MVP, FinnGen and UKBB GWAS data. This first version includes ~300 binary disease definitions across >1.5 M individuals. Browse scans at:
https://t.co/uXf5QBFrCs

[FinnGen @FinnGen_FI]

Last autumn FinnGen hit its target of sampling close to 10% of the Finnish population with more than 500,000 participants. We are happy to announce that the results based on the full cohort are now publicly available for the whole research community:
https://t.co/c6lTge4h4t

[Pradeep Natarajan @pnatarajanmd]

Among British S Asians (individuals ancestrally from Bangladesh & Pakistan living in East London), a missense variant in PIEZO1 (MAF 3.9%, but very rare in non-SAS) leads to lower HgA1c & thus delayed T2D diagnosis https://t.co/uKseMFcwLG @NatureComms

[Kim R. van Daalen, PhD @DaalenKim]

Want to use a cardiovascular disease🫀risk score for primary prevention, but unsure which is the best for your population?🧐

Our work compares CVD risk scores & provides a framework for selecting the most appropriate score.

Just out in @LancetGH!👀⬇️

https://t.co/cJB1IE9JYi

[John Burn-Murdoch @jburnmurdoch]

NEW: we may have passed peak obesity 🎉📈📉🙏

In what might be one of the most significant trends I have ever charted, the US obesity rate fell last year.

[CambridgeCardio @Cambridgecardio]

"'Gene misbehaviour' widespread in healthy population" a fascinating joint study from researchers @aidanbutty @minouye271 @Di_Angelantonio @JohnNDanesh @dirk_paul led by the @sangerinstitute https://t.co/jXtxri6xpe

[BHF Cardiovascular Epidemiology Unit at Cambridge @CAMBRIDGE_CEU]

Out today in @NatureGenet!

Important new updates to the Polygenic Score (PGS) Catalog, & a new software tool that simplifies the calculation of polygenic scores in the context of genetic ancestry

👉 https://t.co/0OR1Lw7m0Z

@iamslambert @minouye271 @sritchie73 @Florent_Yvon

[BHF Cardiovascular Epidemiology Unit at Cambridge @CAMBRIDGE_CEU]

There is a huge need to understand how BMI affects long term multiple long terms diseases. This PhD is jointly with the University of Cambridge and AstraZeneca.

[Sam Lambert @iamslambert]

Interested in a 4-year PhD studying the genetics of BMI and comorbidities? Don't wait, apply for my @AstraZeneca-funded studentship w/ @MikeXiao_JIANG 🔗: https://t.co/8xPwG7eJZH (due October 31)!

@CAMBRIDGE_CEU @HLRI_Cambridge @Cambridgecardio @DPHPC @CambridgeATS

[Nature Reviews Nephrology @NatRevNeph]

New online! A review of polygenic scores and their applications in kidney disease from @atlasmaths and @kirylukk

https://t.co/84neFjIMFS

[AstraZeneca @AstraZeneca]

New research in Nature Genetics introduces MILTON, a cutting-edge machine-learning research tool that accelerates drug targets and biomarkers discovery, with potential to redefine the landscape of preventative health care: https://t.co/u98LTpRVso

[ASCI @the_asci]

ASCI members Krzysztof Kiryluk @kirylukk and Ali G. Gharavi @Columbia evaluate 3 cohorts and find monogenic kidney disorders are associated with an increased risk of kidney failure, higher eGFR decline rate, and lower rates of complete remission: https://t.co/gnOb6W23mp