⭐ #APCCC26 DAY 1 HIGHLIGHTS — A paradigm shift in prostate cancer care
@OncoAlert@APCCC_Lugano#APCCC26@Silke_Gillessen@AOmlin
🔹 FROM HIGH-RISK LOCALIZED DISEASE TO mHSPC — one central theme emerged:
👉 Treatment decisions are becoming more precise, more complex, and more patient-centered
🔹 KEY HIGHLIGHTS:
🧠 RISK ≠ UNIFORM
• High-risk disease is deeply heterogeneous
• Imaging (PSMA PET) is redefining staging → and who truly needs intensification
⚖️ DEBATES SHAPING PRACTICE
• ARPI + RT + ADT → benefit vs overtreatment remains unresolved
• Early salvage RT vs adjuvant RT → timing matters, not just treatment
🧬 BIOLOGY ENTERS THE CLINIC
• Genomics & AI → promising for treatment selection, not universal use
• Need to move from “can we treat?” → who truly benefits?
📊 ENDPOINTS UNDER SCRUTINY
• rPFS & MFS → useful but not definitive surrogates for OS
• Trial endpoints ≠ always patient-relevant outcomes
🧑⚕️ PATIENT PERSPECTIVE AT THE CENTER
• QoL, frailty, toxicity → core drivers of decisions
• Survival alone is not enough → how patients live matters
🔬 mHSPC EVOLUTION
• Triplets vs doublets → intensification guided by risk, biology, and tolerance
• Increasing role of molecular stratification and targeted combinations
🎤 Key voices:
@declangmurphy@ChrisSweens1@BertrandTOMBAL@DrRanaMcKay@LoebStacy@EAntonarakis
Susan Halabi Ian D. Davis David Matheson Erik Briers
Jason A. Efstathiou @DrYukselUrun Karim Fizazi
🔹 TAKE-HOME:
The field is moving beyond “one-size-fits-all” →
➡️ Toward precision, context-aware, patient-centered oncology
📍 An intense and practice-changing Day 1 at #APCCC26
#ProstateCancer #UroOncology #Oncologyy
Platelet rich therapies for ED have long generated interest, but this meta analysis found no clear advantage over placebo on key erectile function outcomes.
Read the full study to learn more: https://t.co/375ztT2c0s
@thairopereira
I wrote this in a moment I never would have chosen. A sudden pause that made me see my life clearly.
The meaning of our work is profound. This experience simply helped me see more clearly what matters most.
“Time is Finite” JAMA
https://t.co/IwkKdyeEWx
@CanesDavid No one can handle the truth — but in medicine (especially in surgery), lies don’t hold up. The hard part is finding the right words to make it clear, without offending, that this just isn’t what they were meant to do.
@SurgiTube I always advance the knot with my index finger all the way down. Tying it like this with your hand tends to put unnecessary tension on the tissue—on a fragile vessel, it can easily tear.
Great talk by Alberto Briganti at @UroOncoBR!
PSMA-PET is reshaping the prostate cancer diagnostic pathway and may also guide decision-making across multiple clinical scenarios.
#UroOnco26#ProstateCancer#PSMAPET
“In the first place, I would set before you as a desideratum the quality which is perhaps the most difficult for a physician to acquire, but which is perhaps the most essential — I mean imperturbability.
A physician who has this quality is calm, cool, and collected in all emergencies; he is not flurried, not excited, not agitated, but meets all the exigencies of practice with a clear judgment and a steady hand.
Imperturbability means coolness and presence of mind under all circumstances, calmness amid storm, clearness of judgment in moments of grave peril.”
Willian Osler