Georgina Sava

Cancer biologist @imperialcollege, working on drug resistance mechanisms in breast cancer.

[Georgina Sava @DrGSava]

Our review on CDK7 inhibitors is out now - really enjoyed writing this!
@simakali1 @imperialCR_UK @imperialCR_UK

https://t.co/HvY0epcteh

[Open Targets @OpenTargets]

Genetic evidence halves the odds of early clinical trial stoppage 🧬💊

Published today in @NatureGenet, @lesya_rzvvsk trained a machine learning classifier to analyse the free-text reasons explaining why 28,842 clinical trials stopped

3 key points:

https://t.co/buMPpOQzPk

[Nicky Whiffin @nickywhiffin]

So excited that our paper “De novo variants in the RNU4-2 snRNA cause a frequent neurodevelopmental syndrome” is out today in @Nature https://t.co/FeDLGm14MB
🧵 1/16

[Damir Varešlija @damirvareslija]

1/7 Our new paper in JNCI! 🎉 Led by Petra Jagust we uncover how RET enables breast cancer cells to metastasise to the brain. Lay summary in thread below. Thanks @BreastCancerNow, @scienceirel, @BreastCancerIre & @IrishCancerSoc for support!
Read here: https://t.co/qVtBFHdoA2

[Patrick Hsu @pdhsu]

What if we could universally recombine, insert, delete, or invert any two pieces of DNA?

In back-to-back @Nature papers, we report the discovery of bridge RNAs and 3 atomic structures of the first natural RNA-guided recombinase - a new mechanism for programmable genome design

[Georgina Sava @DrGSava]

@MagnaniLab_ICR @ICR_London Congratulations! Loved hearing about this work, so exciting to see it out!

[Georgina Sava @DrGSava]

Thrilled to have participated in this work and amazing to see it published!

[Robertus de Bruin @DeRobertus]

The reason cancer cells are sensitive to CDK inhibitors is not what you assumed. @gemmmaawilson & @KarlaVuina discovered it & after 5 years of work, this gem is published. This is the most surprising clinically relevant result to come out of my lab by far!
https://t.co/L0d4ew0D6l

[Breast Cancer Now @BreastCancerNow]

We’re committed to improving treatment, care and services for people living with secondary breast cancer, which is why it’s a central part of our new strategy. Join us and help make a real difference.

https://t.co/OJ0qVlSng7

[Damir Varešlija @damirvareslija]

We’re glad to announce our new study funded by @BreastCancerNow on brain metastasis with coinvestigators Leonie Young @Endoadapt ,Arnold Hill, Carlo Palmieri @cancermedic and myself. @RCSI_Irl @RCSI_Research #MBC

https://t.co/EyfMH3S2gx

[Georgina Sava @DrGSava]

So pleased to have played a part in this exciting study that sheds light on determinants of cancer cell response to CDK7 inhibitors. Especially important following the recent @US_FDA Fast Tracking of #Samuraciclib for advanced #breastcancer.

[Robertus de Bruin @DeRobertus]

Delighted to share @gemmmaawilson study identifying active growth as an important determinant of cancer cell sensitivity to CDK inhibitors. We hope this fundamental work will increase the chances of successful CDK7i approval and guide CDK4/6i clinical use. https://t.co/Jb2cl08HJY

[Imperial College London @imperialcollege]

A 🆕 promising cancer drug discovery #Samuraciclib by #OurImperial Professors @FuchterMatt, @simakali1 Charles Coombes and Anthony Barrett receives @US_FDA Fast Track Status for breast-cancer treatment helping to address unmet medical needs.

Read more: https://t.co/5NZfPM2bnN

[Georgina Sava @DrGSava]

Looking forward to reading this!

[Robertus de Bruin @DeRobertus]

Thrilled our review 'Cell Cycle Control in Cancer' is out! Cancer treatment has to be put in the context of cell cycle control. This means fundamental and clinical researchers and BioPharma must work together!! @helenkmatthews @uclcancer @ucl @MRC_LMCB @CR_UK #BeatCancerSooner

[Georgina Sava @DrGSava]

Thanks to @TheBACR for the great Response and Resistance in Cancer Therapy Conference and for awarding me the @EACRnews poster prize. Already looking forward to the next meeting! And thanks to @simakali1 and our group for their support.

[Dr Michelle Percharde @MPercharde]

Silly/hiring season is here! New postdoc position in our lab @MRC_LMS @imperialcollege in London. Come study chromatin and transposon regulation in development and disease. V.interested in people with experience with hESCs/iPSCs or bioinformatics. *Pls RT* https://t.co/y15AVjI9Nk

[Simak Ali @simakali1]

The CDK7 inhibitor ICEC0942 developed @ImperialSandC,@impchemistry,@imperialCR_UK receives FDA Fast Track Designations https://t.co/KfGyvLeR2k

[Cancer Grand Challenges @CancerGrand]

"The UK must be more ambitious than just clearing the cancer backlog" - interesting piece from our scientific committee member @CharlesSwanton @CRUKresearch on the effects of COVID-19 on cancer screening - https://t.co/8pTUIrcp5y #cancerresearch

[Stelios Chrysostomou, PhD @Chr_Stelios]

Our paper is out - a multidisciplinary effort: Floxacins target RSK4 to improve #lungcancer and #bladdercancer chemotherapy response in mice.
@imperialcollege
@ImperialSandC @imperialCR_UK
@CR_UK @ScienceMagazine

https://t.co/zQHOpPzrXE

[ICR Postdoc Association (PDA) @Postdocs_ICR]

Meet Dr Alison Harrod, whose work was selected to be featured as an oral presentation at this year's ICR Conference!👏 Alison joined @TheDownsLab in @ICR_London in 2019 & her research focuses on synthetic lethal interactions with members of the SWI/SNF complex. 1/3

#Postdocs_ICR

[Joshua Box @DrJoshuaBox]

Excited to share our short review of De novo molecular design and generative models published in Drug Discovery Today! https://t.co/BR4HoyzfMk #pharmatech #drugdiscovery #ArtificialIntelligence #ML #RealTimeChem

[Nathan Brown @nathanbroon]

Great new paper from @DrJoshuaBox & @benedekfabian on molecular design methods. https://t.co/EL06ZdP9Az #CompChem #Cheminformatics #Chemoinformatics #ArtificialIntelligence #MachineLearning

[Laura Tovini @MicrodotLaura]

Pleased to announce our first student conference this summer! An amazing joined effort @QMBCI @TheCrick @imperialcollege @ucl @KingsCollegeLon @ICR_London have a look here👇🏼