AstraZeneca Makes $2 Billion Strategic Equity Investment in Summit Therapeutics
Investment in Preferred Shares Convertible to Common Equity, Equivalent to a Per-Share Price of Summit’s Common Stock of $18.36, Representing a Premium over the Closing Trading Price
Summit Also Enters into Clinical Trial Collaboration with AstraZeneca to Evaluate Ivonescimab in Combination with Sonesitatug Vedotin in Multiple Gastrointestinal Cancers
Summit & AstraZeneca Plan to Enter into a Clinical Trial Collaboration Combining Ivonescimab with Multiple AstraZeneca ADCs and Other Cancer Medicines
https://t.co/Xp5DCiJFmI
AZ are linking with Summit Therapeutics to develop Ivonescimab (VEGF/PD1 bispecific), particularly ADC combos. This promising area of development is moving rapidly. This link will accelerate things further. Robust global data outside of lung cancer is eagerly awaited. @OncoAlert@myESMO@Annals_Oncology https://t.co/41dIbkFfBD
JUST IN and via @Merck + @moderna_tx: A landmark moment for cancer immunotherapy. 🎯
Phase 3 INTerpath-001 is positive: the individualized mRNA neoantigen therapy intismeran (V940/mRNA-4157) + pembrolizumab significantly improved both RFS/DMFS vs pembrolizumab alone after resection of high-risk melanoma.
For years, the idea of designing a treatment around the unique mutations of each patient’s tumor seemed aspirational. Now we have the first positive Phase 3 trial (N=1137) of an individualized neoantigen therapy—and of an mRNA-based cancer therapy.
Personalized cancer vaccines are moving from promise to reality.
Now we need to see the magnitude of benefit, durability, and ultimately OS. But today is an important day for the field—and hopefully for our patients. 👏
Congrats to #CathyWu @DanaFarber for her trailblazing research that is materializing in tangible outcomes! At @DanaFarber_GU we are closely working with Cathy + @DFCI_NeoVax team on several GU protocols, after our @Nature work with @BraunMDPhD et al (https://t.co/BdbKJqMKOw)
https://t.co/Akd0XQt3ml
Gotta love these @JAMAOnc Patient Page📰
#immunotherapy 💉Adverse Effects
1️⃣in5️⃣patients on immunotherapy will have an irAE
Things that increase risk include using2️⃣🧪immunotherapy drugs at the same time & having a history of autoimmune disease 🦠
https://t.co/sY8MS9rgvT
Welcoming to #LALCA21 from LATAM Chair @LuisERaez1 and our @IASLC President @HwakeleeMD. Great agenda and faculty. Don’t miss it! https://t.co/0tMSvE62BM
17 de Noviembre 🤍, día Internacional de la Lucha Contra el Cáncer Pulmonar.
¡No lo dejes pasar y averigua aquí el riesgo de padecer esta enfermedad!
Juntos podemos prevenir, detectar oportunamente y tratar con éxito el cáncer.
🔽🔽🔽
https://t.co/cCnaKHbK8B
@fmuanl@uanl
Tenemos el honor de invitarlos al "Congreso Universitario de Cáncer de Pulmón", a llevarse a cabo el 17 de Noviembre a partir de las 9:00 hrs en modalidad híbrida. Link de Registro:
https://t.co/KCP41BPbso
@fmuanl@uanl@drvmoyervides@DrSalazarMejia@ogarrieta@AndresFCardonaZ
Very happy to see the FDA approval of adjuvant atezolizumab in patients with resected PD-L1+ early stage NSCLC. So excited to have been a part of the practice changing IMpower010 trial! Making a difference in the lives of NSCLC patients! #LCSM
This #article explore the preclinical and pharmacological differences between palbociclib, ribociclib and abemaciclib💡and help us understand the benefits seen with these agents in certain subgroups of patients with metastatic HR positive #breastcancer👏📑
Interesting to read🤩
#ESMO21 is starting in few hours!
I am glad to be presenting our work on the use of #LiquidBiopsy for detection of minimal residual disease after liver metastasectomy in stage IV colorectal cancer (Poster 91P). See you tomorrow :)