Edward Hui

A wantrepreneur. My goal is to become a decent scientist/entrepreneur, and use tech to bridge the gap between rich and poor. MRI scientist at @CUHKMedicine

[Edward Hui @edwardshui]

Are u interested in disease prediction using statistical modelling on multiomics? If so, pls reach out to me and talk more.

Friends and colleagues, if u know someone who may be interested, pls let me know. Many thanks!

#diseaseprediction #multiomics #cuhkmedicine

[Ho Ko @shibadaddo]

Delighted to share the latest paper from our team in Cell Metabolism (https://t.co/OcX5XWP8q7), which has been selected as the cover article for the upcoming December 2025 issue.

In this study, we demonstrate that GLP-1R agonism (using the drug exenatide) confers body-wide multi-omic age-counteraction that rivals rapamycin, the mTOR inhibitor and benchmark anti-aging drug, in aging/aged male mice. Interestingly, we found that this is largely mediated through the hypothalamus in the brain.

Our journey began eight years ago: Upon extensive literature review and in part inspired by the 2017 EXENATIDE-PD trial paper in Lancet, we first hypothesized that GLP-1RAs might have age-counteracting properties. We provided the first experimental evidence connecting aging and GLP-1 agonism in 2020 [https://t.co/m16JMiX6C7], showing that exenatide treatment can potently counteract mouse brain vascular aging. We then demonstrated that such an effect extends to most gliovascular cell types in a companion paper in 2021 [https://t.co/5UexRIVo6C].

Now, building on our prior works, we are delighted to offer the most direct experimental support to date for the growing discussion that this drug class holds significant anti-aging potential inferred from the expanding list of clinical pleiotropic effects—a topic that was recently raised again by Dr. Lotte Bjerre Knudsen at ARDD 2025 and featured in Nature Biotechnology [https://t.co/lJ4oh6HjR7].

Currently, our clinical team and collaborators are focused on leveraging the anti-aging and anti-neuroinflammatory mechanisms to test GLP-1RAs as treatments for cerebrovascular disorders (https://t.co/o4RfihUtO2: NCT05920889 [will be published very soon], NCT06788626 [getting close to the finish line], and NCT05356104 [will take another two years]).

A huge thank you to our entire team and collaborators, editor and reviewers, and to Dr. Jennifer Ma for the cover art that perfectly captures the spirit of our work [stay tuned!], paying tribute to the scientists who made two remarkable discoveries: namely, the isolation of the first GLP-1RA exenatide from Gila monster venom, and rapamycin from Easter Island soil bacteria. Who would have thought that these two natural substances would converge on age-counteraction, at least in the aging mouse!

[Edward Hui @edwardshui]

@ShihYYI @UNCneurology @BRIC_UNC Huge congrats Ian!!!!

[Edward Hui @edwardshui]

This has to go down in history as one of the smartest ways to do parallel imaging! Amazing!

[MRI LUMC @mri_lumc]

This is what happens when you try parallel imaging with multiple low field scanners: parallel imaging - low field style! With a Pilates class included.

[Edward Hui @edwardshui]

@pezlarson @UCSFHMTRC @UCSFimaging Congrats Peder and Xiaoxi et al! Very cool stuff indeed!

[Ian Shih @ShihYYI]

We are excited to share this paper that just came out @ScienceAdvances. @GlialGuy et al. showed that chemogenetic activation of locus coeruleus noradrenergic neurons enhances frontal DMN neuronal activity and connectivity with concurrent vasoconstriction. https://t.co/tTCKRTm8kl

[Edward Hui @edwardshui]

Just curious, would @DeepMind be interested in digging deeper into this problem of disentangling the relationship between brain structure and functions? #GNN #brain

[Edward Hui @edwardshui]

We have finally made it! Please have a look at how we used graph neural network to predict fMRI responses from structural connectome. All comments and suggestions are welcomed!

[bioRxiv @biorxivpreprint]

Prediction of brain functions from structural connectome using graph neural network https://t.co/UwogRYLeY9 #bioRxiv

[Edward Hui @edwardshui]

What an ingenious way to game the bookies! The Secret Betting Strategy That Beats Online Bookmakers https://t.co/Iz90WR7e63

[Edward Hui @edwardshui]

@HYCWong Be bold; take as much risk as you can; read as many interesting literature as you can;)

[IEEE Spectrum @IEEESpectrum]

This #AI pioneer says it’s time for smart-sized, "data-centric" solutions to big issues https://t.co/htyfqOsPrY

[Edward Hui @edwardshui]

What a beautiful way to characterize a system! https://t.co/RHkP14IN1b

[Edward Hui @edwardshui]

The tricky business of adequately modeling relationship https://t.co/jqwMiyBhh6

[Edward Hui @edwardshui]

@pezlarson @qmrlab Brilliant stuffs Peder! 💯💯👏🏼👏🏼

[Edward Hui @edwardshui]

@stevenwhchau Oh got u.

[Edward Hui @edwardshui]

@stevenwhchau @CUHKMedicine Huge congrats to you and your team! What an achievement!

[nature @Nature]

What scientists say about Elizabeth Holmes guilty verdict https://t.co/QfZ2t2NxjK

[Edward Hui @edwardshui]

@SnowhillScience I like this one;)