Emanuela Maxan

Hepatology SpR, Research Fellow at Roger Williams Institute of Liver Studies, interested in gut barrier and microbiome, ncRNA, ACLD

[Martin Smith @martinalexsmith]

💥Cheeky 'little' update from @GencodeGenes v47, almost doubling the number of #lncRNA genes & ~4x more lncRNA transcripts. This was highlighted by @1QINGWANG when observing the greater quality of our reference-guided de novo TxOme assemblies from deep direct RNA sequencing data

[Vijay Ganesh @VGaneshMDPhD]

Excited to report our study in @NEJM on the discovery of deletions in a long noncoding RNA gene 🧬 (𝘊𝘏𝘈𝘚𝘌𝘙𝘙) as the cause of a newly defined human neurodevelopmental disorder 🧠. 🧵1/10 https://t.co/a0V99Xqjaw

[Hans Clevers @HansClevers]

New @ScienceMagazine study in collab with @IHB_Research!
We identified novel receptors on enteroendocrine cells (EECs) that regulate secretion of endogenous hormones. These harbor therapeutic potential for metabolic disease. Read the paper https://t.co/yycQFE72QY  or 🧵⬇️

[Oliver Tavabie @OTavabie]

Delighted to share our work exploring miRNA expression across decompensated cirrhosis and their association with mortality - grateful to my co-authors and supervisors for their support in this work!🧵 ⬇️

@DrVishalCPatel @drmarkmcphail @Inst_of_Liver

https://t.co/tpWRWtEVOs

[Emanuela Maxan @emanuela__maxan]

How inspiring to be at the wonderful #ncrna2024 conference when this was announced♥️

[Ramon Bataller @rabataller]

2024 @NobelPrize to the scientists that discovered microRNA.

In the late 1980s, Victor Ambros & Gary Ruvkun were postdoctoral fellows in Robert Horvitz' lab, who was also awarded the Nobel Prize. What a lab !!

microRNA play a key role in LIVER diseases.

[Gut-HOP @GutOrganoid]

Looking for an exciting research project for a PhD? Would you like to work with mini-guts? Check out project 35 “Determining the impact of pathogenic bacteria in the disruption of the intestinal barrier” @The_MRCDTP to join our teams (#Neveslab, & #Garnettlab) Apply by 29 Oct

[Gut Journal @Gut_BMJ]

#GUTVideo from the paper by Dennison et al on

"Patient-derived organoid biobank identifies epigenetic dysregulation of intestinal epithelial MHC-I as a novel mechanism in severe Crohn’s Disease" via https://t.co/05O6Ul9VE4

Paper: https://t.co/02bhS49O6y

@Zilbauer_M @SCICambridge @Cambridge_Uni

[Jasmohan Bajaj @JasmohanBajaj]

In a large public system what is the likelihood that pts w #alcoholusedisorder & ⬆️FIB-4 are referred to #hepatology?..<40%!
✅need better integration #mentalhealth & #gastroenterology
✅ older pts w #mentalhealth disorders had⬇️referral
We can do better! https://t.co/GvOknuVQ4q

[Elliot Tapper @ebtapper]

What can we do to prevent falls in patients with cirrhosis?

4% of admitted patients have falls
Falls carry increased risk of death

Great study from @nadaabedin in @HepCommJournal

Open access: https://t.co/37XV65cYc9

[Cirrhosis Care Alberta @CirrhosisCareAB]

🩺 Make sure your patients have the best nutrition support for managing cirrhosis. Find, print, & share comprehensive resources, including videos and written handouts on what to eat, when to eat, and portion sizes. Check out the Nutrition in Cirrhosis handout for a great start!

[Eric Topol @EricTopol]

An exciting advance in Type 1 diabetes
First person to receive her own stem cells, reprogrammed with transcription factors, to reverse it!
@CellCellPress
https://t.co/NzhTO6tZrg
@Nature
https://t.co/zbNNtLCrot

[John Damianos, M.D. @john_damianosMD]

What defines a healthy gut #microbiome?

#MedTwitter #GITwitter

https://t.co/DsPj4MzikU

[Nature Reviews Gastroenterology & Hepatology @NatRevGastroHep]

New online! A resource for the food microbiome and its links with the human microbiome https://t.co/OZ72FUqitY

[HEPATOLOGY Journal @HEP_Journal]

Original Article

Predictors of long-term clinical outcomes after TIPS: An ALTA group study

Nobel et al.
​​#LiverX
https://t.co/Xyea4ifD2f

[Gut Journal @Gut_BMJ]

Read the #GUTRecentAdvancesInBasicScience paper by @MariettaIacucci et al on

"Opening the doors of precision medicine: novel tools to assess intestinal barrier in inflammatory bowel disease and colitis-associated neoplasia" via

https://t.co/quyqmaJxDy

@Pharmabiotic @UCCResearch #CRC #IBD

[Ejv @ejvillablanca]

Not all is microbiota dependent…when talking about #mucus

Kudos ⁦@Mucus_Man⁩ et al!

Antibiotics damage the colonic mucus barrier in a microbiota-independent manner | Science Advances https://t.co/JZil8Cqz8a

[Ash Paul @pash22]

Why free school meals are the hidden bedrock of a better society https://t.co/9mOin54jKS via @GilesYeo @ajjolley

[The Francis Crick Institute @TheCrick]

Cells in the intestine constantly renew as they get worn down or damaged ♻️

A team from across the Crick has identified a gene that plays a key role in this process in mice, opening the door for new research on gut tissue repair.
https://t.co/6B01Bq7vL9

[Ewan Forrest @EwanForrest1]

Not everyone drinking excess alcohol will develop liver disease. Great work @fredho42, @Fanny_Petermann et al showing additive interaction of diet and alcohol for ArLD, after controlling for MASLD risks. @SALVE_liver @ebtapper #livertwitter

https://t.co/fyRgiwYEPM