Emory Alvarez Lab

Neuroscience lab in the Department of Cell Biology at Emory Univeristy studying everything from locomotor circuitry to neuroinflammation following PNI

[Emory Alvarez Lab @emoryalvarezlab]

Huge congratulations for another successful semester of research and poster presentations by our lab's undergraduates. Desi Ukmar and Veronica Sanchez (Sr), Rodrigo Garcia (Jr), Briella Lucadamo (Soph), and their mentors @ZoeHaleyJ @PottorfTana Elizabeth Lane. @emorycollege

[Emory Alvarez Lab @emoryalvarezlab]

We are thrilled to (re)introduce our recent graduate, Dr. Olivia Mistretta! 🥳 Although she will be missed, she is destined for a great career as a scientific writer and aspiring MSL. Congratulations Dr. Mistretta!! @neurophd_emory @EmoryMedicine @EmoryUniversity

[Emory Alvarez Lab @emoryalvarezlab]

Congratulations to current @neurophd_emory student @willieneuro and former postdocs Ryan and Paula on their recent publication showing that GABA/glycine neurotransmission on regenerating motoneurons facilitates axon growth and muscle reinnervation post PNI
https://t.co/chXgAWUv2M

[Emory Alvarez Lab @emoryalvarezlab]

New paper drop from our graduate student Andrew Worthy on spinal cord V1 interneurons shaping motor output.
@laneygradschool @neurophd_emory @EmoryMedicine

[William McCallum @willieneuro]

Brand new (10 years running…) work from the @emoryalvarezlab out today - it’s a neuroanatomy feast. Joining the lab and seeing this take its final form I knew I was in the right place. The whole team is legendary!! (and V1s are the coolest)

https://t.co/FEVmpH0Zyu

[Emory Alvarez Lab @emoryalvarezlab]

Former Postdocs Ryan & Paula and current @neurophd_emory student @willieneuro share their work on how GABA/glycine neurotransmission on regenerating motoneurons facilitates axon growth and muscle reinnervation.
@laneygradschool @EmoryUniversity

[William McCallum @willieneuro]

Latest paper from the @emoryalvarezlab , which I'm grateful to have been able to contribute to, and got me started on my current love affair with motoneurons

https://t.co/CqCQvW5XWr

[Emory Alvarez Lab @emoryalvarezlab]

This past week, senior graduate student @PottorfTana was awarded the prestigious @NIH Outstanding Scholar in Neuroscience Award! 🥳🥳🥳

#OSNAP #OSNAP2024
@NINDSfunding @NIH_NINDS @ncats_nih_gov @EmoryUniversity @EmoryMedicine @laneygradschool

[Dr. Tana Sue Pottorf (Nitcher) @PottorfTana]

Beautiful weather to visit Bethesda, talk science, and be a recipient of the 2024 Outstanding Scholar in Neuroscience Award Program #OSNAP #osnap2024 @NIH_NINDS @NIH @ncats_nih_gov

[Emory Integrated Cellular Imaging @emoryici]

Are you an Emory User with a gorgeous microscopy image? Please consider entering the ICI-Core Day Image Competition. Grand prize is $200. Images are due by 11/8 https://t.co/BI8aLlpVkL

[Emory Alvarez Lab @emoryalvarezlab]

Our highly collaborative Department of Cell Biology is recruiting for a tenure-track faculty position! Come leave an impact on this world with us!

[LeritLab @LabLerit]

Come be my colleague!

The Dept of Cell Biology @EmoryUniversity is recruiting a developmental cell biologist.

🔬Do you study mechanisms of development using cell biological (and other) approaches? Join us!🔬

TY for RT!

https://t.co/2szhalywtG

[Emory Alvarez Lab @emoryalvarezlab]

Senior graduate student @PottorfTana representing the neuroimmune side of the Alvarez lab at @PNSociety1 in Montreal!

[Dr. Tana Sue Pottorf (Nitcher) @PottorfTana]

Very proud to have brought a sprinkle of the spinal cord to @PNSociety1 #PNS2024

[Dr. Tana Sue Pottorf (Nitcher) @PottorfTana]

We may be at the PNS meeting but there are lots of implications from PNI in the CNS! Interested? Come check out my work for a flash talk today at 10:45am or a poster Monday at 2:15 (poster # P350) #PNS2024

[Emory Alvarez Lab @emoryalvarezlab]

Big congratulations to our senior graduate student @PottorfTana recently being awarded the 2024 @NIH #OSNAP. We look forward to sending her to Bethesda in November to share our neuroimmune work and meet with NIH program officials🥳 @EmoryMedicine @neurophd_emory @laneygradschool

[Dr. Tana Sue Pottorf (Nitcher) @PottorfTana]

Absolutely thrilled to share I have been selected as an award recipient for the @NIH #OSNAP 2024 cohort. Looking forward to meeting all my fellow recipients and sharing some of my data on microglia-motoneuron dynamics in November! 🎉 Big thanks to the A lab for continued support.

[Emory Alvarez Lab @emoryalvarezlab]

@aeworthy is a 1st-year neuroscience PhD pre-candidate who recently joined our lab to perform his dissertation through @neurophd_emory @laneygradschool @EmoryMedicine @EmoryUniversity

Before grad school, Andrew received his BS from @emorycollege and was a research specialist.

[Emory Alvarez Lab @emoryalvarezlab]

Inhibitory interneurons, such as Foxp2-V1, are crucial for motor development and are affected at early stages of pathology in motor neurodegenerative diseases like ALS. Here, graduate student @aeworthy presents a comprehensive examination of V1 subtypes.
https://t.co/WKAqfgnsle

[Srikant Rangaraju @rangarajulab]

Native state cell type specific proteomics reveals mechanisms of early dysfunction in PV INs in AD pathology ! @rangarajulab
@MJMRowan Congrats to co-firsts Prateek and Annie and all co-authors on this publication in @NatureComms. Go team

https://t.co/BBtD4ZJ9Cw

[Emory Alvarez Lab @emoryalvarezlab]

One of our senior undergrads, Celia Bianco, defended and received Highest Honors for her thesis on the age-dependent involvement of C1Q after peripheral nerve injury in mice. We wish Celia the best with her future endeavors @emorycollege @Emory_NBB #opentowork

[Emory Alvarez Lab @emoryalvarezlab]

@EmoryMedicine @laneygradschool @neurophd_emory

[Emory Alvarez Lab @emoryalvarezlab]

The Alvarez lab is very proud of our graduate student @willieneuro for his presentation on tools for high res EMG's at the Sensorimotor Circuits for Limb Control meeting @OISTedu this past March, and additional presentation @EmoryUniversity @emoryDSAC GDBBS Research Symposium.

[Emory Alvarez Lab @emoryalvarezlab]

We are very proud to share one of our senior graduate students' work in developing a novel way to study locomotor development in mice. It is Olivia's hope that "this technique will bring new insights to neurodevelopmental disorders, movement disorders, and so much more."

[JNP @JNeurophysiol]

➡Olivia C. Mistretta et al. present novel methods to study neonatal air-stepping in newborn mice in this newly published research.

🖱 https://t.co/SMtFUxQXID

@LabLerit #AirStepping #neonates #kinematics #RhythmicLocomotion

[Emory Alvarez Lab @emoryalvarezlab]

@GeorgiaTech @laneygradschool @EmoryUniversity @EmoryMedicine @neurophd_emory @willieneuro @PottorfTana @TravisRotterman

[Emory Alvarez Lab @emoryalvarezlab]

We are excited to share the following publication which was a joint effort with the Cope lab @GeorgiaTech Herein, we elucidate the differing effects on spinal cord plasticity and inflammation between crush and cut peripheral nerve injuries.
🧵
https://t.co/wQnLytytTB

[Emory Alvarez Lab @emoryalvarezlab]

Figure 6-7: If ccl2 is ablated from microglia, the sensory afferent -> motoneuron synapses (quantified via VGlut1) are preserved, muscles are still reinnervated, however, the stretch reflex remains lost. Further, ccl2 ablation does not alter amount of peripheral infiltration.

[Emory Alvarez Lab @emoryalvarezlab]

Figures 4-5: We see increased peripheral immune cell infiltration into the spinal cord in the cut compared to the crush. This corresponds to differing microglia CCL2 (a pro-inflammatory chemokine) expression.

6/n 🧵