Norman Goodacre

[Greg Preibisch, MD @GregPreibisch]

https://t.co/1O8sYBqunL

[Bowen Jing @bjing2016]

Binder design has come of age thanks to generative models—but how can we access the wider array of dynamic, multistate protein functions, so elegantly employed by nature?

@mihirbafna14 and I are excited to share SwitchCraft, a framework for designing such functions. (1/7)

[Norman Goodacre @EntropieSt]

@biohub excellent

[Norman Goodacre @EntropieSt]

@sokrypton Interesting! I am wondering how dependent this is on protein and location of positions. Thinking about ablation approaches - I've seen as few as 2 residues ablated lead to an alt conf !

[Norman Goodacre @EntropieSt]

@GMondaSilva Fascinating stuff. How does this compare to something like AF-Cluster?

[Yohei @yoheinakajima]

Baby AGI on Streamlit

[Nature Communications @NatureComms]

A double-viewed hierarchical graph learning model, HIGH-PPI, to predict protein-protein interactions and extrapolate the molecular details involved. #protein-protein interaction # hierarchical graph learning

https://t.co/BxYFTTyOTK

[Ali Madani @thisismadani]

ChatGPT for biology? Excited to share our work on LLMs for protein design out today @NatureBiotech
https://t.co/j6lYXYGWxP

+ Proud to publicly announce @ProfluentBio with a $9M seed round to tackle meaningful challenges in biology with AI. Join us!

[Ezgi Karaca @Ezgi_Karaca_]

It's finally time to discuss the main highlights of #CASP15's assembly category, where we had these beatiful 41 targets:

[Norman Goodacre @EntropieSt]

@johncumbers I'd imagine it would tell you a story that's surprisingly familiar. An entity goes about its business, behaving in a way that's innate, finding synergies with companions in its ecosystem. Except in this case, the ecosystem around it is ancient, immortal, and recurring..

[AK @_akhaliq]

Dynamic-Backbone Protein-Ligand Structure Prediction with Multiscale Generative Diffusion Models
abs: https://t.co/JdkAAMUoV1

[Norman Goodacre @EntropieSt]

@_akhaliq This is rather exciting.

[Mohammed AlQuraishi @MoAlQuraishi]

Exciting to see the preprint on ESM2/ESMFold from @alexrives group out: https://t.co/JccyVnt6OE. Far larger protein LMs than ESM-1b and applied to MSA-less protein structure prediction. Can't wait for code/models!

[Norman Goodacre @EntropieSt]

@bloodberry_tart I’ll consider that a partial answer. C-

[Norman Goodacre @EntropieSt]

@bioRxiv_synbio Nice

[Haas Lab @haas_lab]

Excited to share our recent work on single-cell proteo-genomics of human hematopoiesis and leukemia. Mapping up to 197 surface markers & transcriptome enables us to design rational cytometry schemes that accurately reflect topologies of cellular systems https://t.co/EkFTR2JB1H

[Norman Goodacre @EntropieSt]

Bonjour #Paris #AI