Biggest paper yet from the lab out now in @ImmunityCP! It is a massive #openscience resource on #tissueTregs, and what makes #Tregs tick in the #tissues. Spoiler-alert: Tissue Tregs are really different from what we all thought. 🧵 1/21
https://t.co/k8q7LhMewB
Thrilled that our huge team effort with @Kornfeld_JanW is out in @NatMetabolism 🥳 supported by @TRR_BATenergy A huge thank you to all collaborators! If you want to know how a truncated AC3 isoform regulates #BAT function, have a look here https://t.co/sOZAersi2D
Sticking with a bad decision is not a triumph of commitment. It's a failure of courage.
The quicker you are to admit you were wrong, the sooner you can start making it right.
Persistence is not about staying on a path. It's about finding a better path to your goal.
Excited to share our review on NLRP3 #inflammasome signalling in #Alzheimer’s disease with @eickelatz. Check it out to learn the latest on NLRP3 activation, the inhibitors in #clinical trials and new NLRP3-targeted therapies under development
https://t.co/sdj0TWifRD
An exceptional review of how obesity revs up the immune system and inflammation, including what happens with weight regain
https://t.co/6Z1Rb4bE6P @ScienceTM@ahasty4@VUMChealth
Where do #TissueTregs come from? The previous standard model is the "seeding and specialisation" model, where #Tregs enter from tissues, turn on a dedicated transcriptional program per #tissue, and dwell indefinitely in that tissue as specialised cells.
1/3
I am very happy to share our recent paper published in Nature Communications about G4s and their role in DNA damage! 🥳 Check it out! @PaeschkeL
https://t.co/GHnQgOlXYr
Medullary TECs have the potential to differentiate into various types of molecularly distinct and functionally defined cells that contribute to both induction of central tolerance & homeostasis of other thymus-resident populations @Nature
https://t.co/Hg1m5YBrQH
Interested in working on primary #cilia signaling funded by @NSF@dfg_public, combining genetics, proteomics, optogenetics at @TamaraGenes@MickLab@DagmarWachten ? Apply now! Our labs have open calls for a #PhDposition and a technician. Please get in touch if you are interested!
BREAKING: The drug semaglutide, made by 🇩🇰 Denmark's Novo Nordisk, is found to cut risk of heart attacks and strokes by 20%, possibly making it one of first drugs to have effect of both reducing cardiovascular events and helping with weight loss.