Erin Thompson

Biologist @Octantbio, coffee snob, injured runner-turned-cyclist

[Erin Thompson @ernpossible]

@willowcoyote @UCSF @UCSF_BTS @QBI_UCSF WOOHOO!! Huge congrats, what exciting news!

[Erin Thompson @ernpossible]

@FloChardon @TroyMcDiarmid Wow, huge congrats Flo! Awesome work

[Erin Thompson @ernpossible]

@benjaminbarad @OHSUSOM YEESSS huge congrats, very exciting!!!

[Erin Thompson @ernpossible]

Very cool, especially re: structure based drug design! Congrats Keedy lab, again proving RT is best 🔥🔥

[Daniel Keedy @DanielKeedy]

TLDR: Many small-molecule fragments bind differently to proteins at room temperature (red) instead of the usual cryogenic temperature (blue): new binding poses, binding sites, solvation patterns, and even allosteric protein responses. (2/)

[Erin Thompson @ernpossible]

Have you ever wanted to make a library that includes indels? Well now you can! Super excited this is finally out, congrats @willowcoyote

[Willow Coyote-Maestas @willowcoyote]

Our 1st manuscript on DIMPLE from @ucsf @QBI_UCSF and my 1st senior author!
If interested in DMS, indels, high throughput assays, membrane proteins, and how we can combine these to explore protein evolution, disease, and structure function check it out!
https://t.co/EoxZ9GFagQ

[Erin Thompson @ernpossible]

@irisdyoung Literal feeling of terror when I read this

[Matthew Ravalin @MatthewRavalin]

Happy to share the @biorxivpreprint for my first bit of work w/ @aliceyting. Together with @heegwangroh, we built a simple and versatile single-component luminescent biosensor for detecting the SARS-CoV-2 spike protein.
https://t.co/GPU8D4MwlA

[Erin Thompson @ernpossible]

Have to give a special shout out to my old labmate @willowcoyote, presenting on a library generation method, DIMPLE, to address the difficulty in making systematic indel libraries. He recently started as a Hannah Gray Fellow, go check out his work! #VariantEffect22

[Alex Cagan @ATJCagan]

Lightening talks round 2 at #VariantEffect22

[Erin Thompson @ernpossible]

.@LindorffLarsen on disentangling stability-activity-folding contributions of variants that are important for fxn and using this data to predict effect mechanism for disease variants #VariantEffect22

[Alex Cagan @ATJCagan]

Kresten Lindorf-Larsen on combining evolutionary sequence conservation and protein stability assay data to inform our understanding of protein function #VariantEffect22

[Erin Thompson @ernpossible]

On our way to to explore Toronto with our Canadian guide @fraser_lab #VariantEffect22

[Erin Thompson @ernpossible]

Ok fellow MAVE/DMS enthusiasts, I think the time has come that we standardize heat map coloring. Personally like blue for gain of function, red for loss of function (reasoning red = bad in my mind) but could be persuaded otherwise @varianteffects #VariantEffect22

[Thompson Lab - UC Merced @MThompsonLab]

🚨PREPRINT ALERT!!!🚨
I’m beyond excited to finally share this work, where we demonstrated the use of temperature-jump as a perturbation for time-resolved crystallography, specifically to study protein dynamics! 🔥💎
https://t.co/J8e9yY5pQR

🧵 1/32

[Erin Thompson @ernpossible]

https://t.co/HwsfnNBayd

[Benedetta Bolognesi @Bennibolo]

Latest from our amyloid factory with @mseumaar and @BenLehner : Deep Indel Mutagenesis reveals an Atlas of Amyloid Aggregation. Most frequent comment mumbled while writing this paper: "Oh my - It’s such a stunning dataset!".
https://t.co/qGPzLIpcGp

[Erin Thompson @ernpossible]

.@Bennibolo using MAVEs to find Aß muts that accelerate amyloid formation & to show more comprehensive mutagenesis useful: many indels/truncations of Aß increase aggregation. Core muts strongly impact amyloid nucleation #VariantEffect22

[Alex Cagan @ATJCagan]

Benedetta Bolognesi on deep indel mutagenesis reveals novel Amyloid beta mutations that acceleration amyloid formation and are likely pathogenic #varianteffect22

[Erin Thompson @ernpossible]

#VariantEffect22

[Erin Thompson @ernpossible]

.@JuliaDiumenge presents how to disentangle folding vs. binding contributions to variant effects. 2+ muts help, but libraries complex. Can constrain additional measured trait & do multidimensional mutagenesis. Fit thermodynamic models & mapped allostery,
https://t.co/885kWV7x74

[Alex Cagan @ATJCagan]

Talk by @JuliaDiumenge on global mapping of the energetic and allosteric landscapes of protein binding domains - searching for allosteric sites #varianteffect22

[Erin Thompson @ernpossible]

Excited to be here at #VariantEffect22 with my other @OctantBio colleagues. A great kickoff to the conference hearing about how clinical data + functional data can be used to improve variant interpretation @conor_j_howard @diane_dickel @srikosuri @n_s_abell

[Alex Cagan @ATJCagan]

Conundrums and challenges of clinical variant interpretation @clare__turnbull gives opening keynote at #varianteffect22

[Vatsan Raman @vatsanraman]

Where are allosteric hotspots located in a protein? What properties differentiate such hotspots from other residues? We combine deep mutational scanning of four homologs with machine learning to reveal molecular rules governing allosteric hotspots.
https://t.co/CjRBsfLwYo

[Catalio Capital Management @CatalioCapital]

Very happy to announce the close of @OctantBio’s $80M Series B, led by Catalio, along with @a16z, @8vc, @bmsnews. Looking forward to working with @srikosuri, @rhomsany & their team to further develop Octant's innovative synthetic biology platform https://t.co/lfcVwAiEnO