The damage from Hurricane Helene is heartbreaking. A good friend’s local shop has been destroyed, leaving workers without jobs. Please consider donating or sharing to help rebuild. Every bit counts. https://t.co/sB1oZYICIX
Checkout our new @MolecularOncLab website!
https://t.co/geJi9rsnxl
We are looking for new wet lab members to join our multi-omics and liquid biopsy efforts (research tech and post-doc level -the latter for folks with a PhD in cancer biology-), contact us if there is interest!
Exciting news of the week - just received my print copies of my latest journal cover! For Diabetes (journal for the ADA) Dax Fu, et. al.
@JohnsHopkins@JhuMedart#molecularvisualization#sciart https://t.co/oIGQiflAlg
My pick for "the" mobile DNA paper of 2023 is actually two studies published back-to-back @Nature reporting the long-sought structure of L1 ORF2p _and_ fundamental insights into the mechanism by which L1 jumps. Amazing work. 1/n
https://t.co/1Woxda7Kfh
https://t.co/1Woxda7Kfh
https://t.co/2NUeefEIZX
Really cool video on LINE-1 and our work on ultrasensitive detection of Orf1p. I love their description of the total lack of creativity in naming the LINE-1 proteins. Orf1=“Protein McProtein Face”.
https://t.co/ucfZvlhiI1
Researchers from @MGHPathology and colleagues discover that structural analysis and inhibition of human LINE-1 ORF2 protein reveals novel adaptations and functions, in a @nature study. https://t.co/jc53O1yzk5
Did you know that a significant portion of our genetic code, once dismissed as “junk DNA,” might hold a key to understanding diseases?
Scientists have uncovered what could be a game-changer in our understanding of health and disease:
https://t.co/tZvm8XNrSK
Using single particle cryo-EM, we determined three structures in different functional states. Apo ORF2p is in an active “thumb up” state; in contrast, apo viral RTs adopt an inactive “thumb down” state. This may explain ‘cis preference’: L1’s penchant for binding its own RNA
We purified ORF2p ‘core’ and determined of a 2.1 angstrom crystal structure, facilitating discovery of two novel domains we name the ‘tower’ and ‘wrist’. These flank the fingers-palm-thumb domains of reverse transcriptase (RT), which grip the nucleic acid like a “right hand”