Fan Xu

PhD student | Göritz Lab @karolinskainst🇸🇪#perivascular_fibroblast #BAM MSc at Chinese Academy of Sciences🇨🇳 #neuroimmune #stroke

[Julia Belk @juliabelk]

Gaining therapeutic access to the human brain is one of the biggest unsolved problems in biomedical science.

Today @nature, we uncover a massive influx of immune cells into the human brain during aging, revealing that the brain is more accessible than previously thought. 1/
https://t.co/BuHdVk1V2I

[Science Immunology @SciImmunology]

Cerebrospinal fluid #macrophages are a distinct population from #microglia and border associated macrophages, proposes a 2022 Review.

Read more during #BrainAwarenessWeek: https://t.co/mJKcPfy0O6

[Oren Gottfried, MD @OGdukeneurosurg]

Clinical presentation of MCA and ACA strokes

[Jason Sheltzer @JSheltzer]

Let’s play a little game.

Let’s say that you’re the CSO at a cancer pharma company, and you have to choose a target to go after.

Here’s a gene – high expression is associated with poor prognosis in brain cancer. Looks like a good candidate for an inhibitor right?

[Hao Yin @HaoYin20]

Single cell RNAseq reveals Fibrogenic signatures of #Pericyte (Tbx18-CreER+) in ischemic🐭🫀(LAD-MI) & 🧠(photothrombosis)

Postn+Col1a1+ pericyte-like cells in🫀🧠fibrotic scars

Relative contributions vs fibroblast?😁

Dr. Reza Ardehali lab @CircRes 2021
https://t.co/zLebihIRik

[Pluchino lab - Regenerative Neuroimmunology @Pluchinolab]

Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration: Neuron https://t.co/QkiUjC10pu

[David Holtzman @holtzman4]

Congrats to Samira on this beautiful work. https://t.co/dnye4YZx2k

[Hugo Chrost @chrost_hugo]

An useful stroke primer.

Credits: Mai Stewart.

#MedTwitter

[Journal of Experimental Medicine @JExpMed]

.@RawatKSM, Tewari, @Claudjak et al. @GeiselMed show that dendritic cells use the chemokine receptor CCR7, while monocytes follow chemokines secreted by migratory DCs to reach lymph nodes and control immunity. https://t.co/9RYrCoTFgB

@ArlindUC17 @NnamChinaza @bart_lambrecht

[Journal of Experimental Medicine @JExpMed]

This study by Yoshihara and Okabe @osaka_univ_e illustrates the homeostatic roles of fibroblastic reticular cells in the formation of non-classical lymphoid tissues. https://t.co/hX4uB5D47n

[Weizmann Institute @WeizmannScience]

Congratulations to Prof. Michal Schwartz of the Brain Sciences Department, who has been announced as the recipient of the Israel Prize in Life Sciences

[Pluchino lab - Regenerative Neuroimmunology @Pluchinolab]

Brain injury accelerates the onset of a reversible age-related microglial phenotype associated with inflammatory neurodegeneration | Science Advances https://t.co/VgUuFpngnb

[David Holtzman @holtzman4]

Congrats to Xiaoying Chen and all our wonderful collaborators on this important set of findings. https://t.co/GzQGfrltBI

[Osama Harraz @OsamaHarraz]

✴️Astrocyte Endfeet in 🧠Brain Function and Pathology: Open Questions ❓❔❓
https://t.co/U9ADs2sSFD
@AnnualReviews
@B_DiazCastro @StefanieRobel @Mishra_CBF_Lab

[Konrad Hoeft @KonradHoeft]

We are so thrilled to see our new study out in @CellReports today (https://t.co/EZwQOXe1mF)! We investigated #platelet-#macrophage-crosstalk in #fibrosis identifying a platelet-instructed SPP1 macrophage subset that controls fibroblast activation. 1/11

[Nature Neuroscience @NatureNeuro]

Perivascular macrophages and fibroblasts induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of #Alzheimer’s disease

New from @SebastiaanDeSc2 @soyonhonglab @UKDRI @ucl

https://t.co/Tk4REc1rFT

[Fan Xu @fanfunfunever]

Archive of CMB retreat

[Hao Yin @HaoYin20]

Antigen-presenting #Pericyte #MultipleSclerosis

PDGFRβ+ Pericyte MHCII KO->
In vitro
⏬CD4+ T cell proliferation & activation

In🐭adoptive transfer EAE
⏫CD3+ T cell entry
No change in BBB, CD4+ T cell, Mɸ, cytokine

Dr. Luisa Klotz lab @IJMS_MDPI 2022
https://t.co/9YknA7LBO0

[Joe Miano @JoeMiano3]

Vascular smooth muscle cell-restricted Cre driver just published in Nature Cardiovasc Res circumvents previously lethal visceral myopathies. https://t.co/C5EQzFM8ol

[Bo Peng @BoPengMicroglia]

We are proud to announce that we found who removed the debris of dead microglia. In a word, non-professional phagocytes phagocytose the debris of professional phagocytes in the central nervous system.
https://t.co/YfqYwMs1va