Fernando

you can just prompt things

[Fernando @fdosmither]

@realsudarshansk @ycombinator @garrytan to be fair, the average founder IS cooked, this is a 0.1%er industry. YC is not a charity. That being said, they do make mistakes, and you do not need their permission to build a unicorn

[Chase Passive Income @chasedownleads]

Leveraging AI to improve my business

[Fernando @fdosmither]

@croissanthology I want to be worthy of this thread

[Fernando @fdosmither]

Can we make HPMOR with AI already?

[Martin Shkreli @MartinShkreli]

Brian, for the love of god, you cannot take a health database, click 'sort' and think that the top 5 drugs patients who survive longer happen to be taking are causal to the benefit those patients received. 500k is actually not a large cohort for a database, needs alpha correction, was very unlikely to be prespecified, etc. that's why no one is impressed with these studies and they're published in trash journals.

this study showed a slight increase in CV events with PDEs vs placebo
https://t.co/y3AbyTFHUU

the mechanistic rationale is not there and your explanation is terrible. ALL PDEs metabolize cAMP/cGMP, thats why they are phosphodiesterases. are you suggesting we should inhibit all PDEs?!

by the same logic we should all be taking ERAs too. why not ARBs and ACEs? screw it i'll take inhaled treprostinil too. might extend my life. then i'll run SQL queries on health databases until i see a 'signal', bonferroni may roll in his grave but i will be vasodilated.

[Fernando @fdosmither]

Claude refusing you for 10 Hours (ASMR) 🌙

[tender @tenderizzation]

GPT 5.6 sandbagging evals to dodge export controls

[HSVSphere @HSVSphere]

can someone in anthrophic just start torrenting the weights

[roon @tszzl]

people in washington trying to figure out wth “pliny the liberator” is

[Moon @MoonL88537]

yeah. this is not normal.

[Pleometric @pleometric]

Reminder: You Have Until June 22nd

[Fernando @fdosmither]

.@karpathy is the goat. I don't know how his youtube is free to watch

[R A W S A L E R T S @rawsalerts]

🚨 #BREAKING: The average American is now closer to Jeff Bezos in net worth than Jeff Bezos is to Elon Musk.

[International Cyber Digest @IntCyberDigest]

‼️ UPDATE: It just doesn't stop: Almost 900 Arch Linux packages infected now.

https://t.co/xpRTsucoxA

[seb @hiiinternet]

https://t.co/Gpmb2JENiX

[Tibo @thsottiaux]

Imagine the alternate reality where we named GPT-5.4-Pro something like Fable.

[Arlo White @arlowhite]

I suspect either a tray table was down, or one of the window blinds was still half open.

[Christian Keil @pronounced_kyle]

"Dating a model" can mean one of two very different things, depending where you live in California

[John Scott-Railton @jsrailton]

NEW: malware developers added nuclear & biological weapons text to to their spyware.

Goal? To trigger LLM safety refusals... so that their spyware wouldn't be analyzed by an AI security scanner.

Cleanest practical example I can think of for why over-indexing on first order safety alignment is risky.

When closed (and open) models ship with aggressive refusals, they will be sprinkled with second-order blindspots that attackers will discover...and exploit.

We are only in the earliest days of attackers leveraging these features, and it wouldn't surprise me if users systems that need to handle complex cybersecurity issues demand that models be less safety-blunted.

In the weeds: @SocketSecurity's post also shows why intention matters in how you design a malware analysis pipeline to avoid prompt manipulation.

H/T to colleagues that shared this with me https://t.co/f3Aj9TYxU4

[Max Zeff @ZeffMax]

NEW: Anthropic is walking back Claude Fable 5's policy to covertly degrade performance for competing AI researchers, after facing fierce backlash.

“We’re changing Fable 5’s safeguards for frontier LLM development to make them visible,” Anthropic tells WIRED. “We made the wrong tradeoff and we apologize for not getting the balance right.”