Fahima Dossa, MD PhD

Surgical Oncologist & Clinical Epidemiologist @CedarsSinai @DeptSurgeryCS | Soft Tissue Sarcoma & GI Malignancies | 🇨🇦

[Erman Akkus @Erman_Akkus]

Systemic therapy, gastrectomy, cytoreductive surgery, and hyperthermic intraperitoneal chemotherapy versus systemic therapy alone for gastric cancer with limited peritoneal metastases (PERISCOPE II): final results of a multicentre RCT phase III https://t.co/V8f6madiNj

[Fahima Dossa, MD PhD @fdossa]

@jgong15 @NIH @theNCI @CedarsSinai @MOASC_Office @crisbergerot @PauloBergerot @CParkMD @NIHFunding @NazliDizman @ronanhsieh @DaniCastilloMD @CancerNetwrk @KReddyMD Congrats!! 🌠

[Duke Surgical Oncology @DukeSurgOnc]

🎙️ Proud of our own former @DukeSurgRes Resident, Dr. Nellie Farrow (now @EmoryMedicine)! Check out her new @SocSurgOnc micro-learning on MSLT-3 & melanoma paradigm shifts with Dr. Mark Faries of Cedar Sinai. #SurgOnc

https://t.co/uFGy6r64lU

[Journal of Clinical Oncology @JCO_ASCO]

Watch and Wait for Rectal Cancer: A Risky Gamble or a Safe Strategy for Patients With a Near-Complete Response? Co-authored by @fdossa.

Read the full article. https://t.co/Uc3mfOxyXW

[Hannah Abrams, MD @HannahRAbrams]

I was skeptical of virtual twin studies but @fdossa convinced me they have a role, especially for our patients with rare cancer. Look forward to seeing what’s next out of this line of research #ASCO26 #sarcoma 👇🏻

[Fahima Dossa, MD PhD @fdossa]

SARC041: confirms clinical activity of abemaciclib for pts with advanced dediff liposarcoma ✅

👏🏽 to Mark Dickson @MSKSarcoma on this work and Paolo Casali @casali_pg @IstTumori for an excellent discussion

Open❔role in resectable disease

#ASCO26

[Jun Gong, MD @jgong15]

A much needed breakthrough for our pts with #PDAC 👏👏. Glad to see amongst investigators for this important study, our fearless #GImedonc leader @DrHendifar as an author in the @NEJM manuscript

@OncoAlert @DrArsenOsipov @AGangiMD @_BrainyMD_ @CFerroneMD @fdossa @CedarsSinaiMed

[SSAT @SSATNews]

Congratulations to @DrDrFoster of @Stanford University, recipient of the SSAT Career Development Award! 🎉 Dr. Foster’s work reflects the innovation and dedication that continue to advance the field of digestive diseases.

#Surgery #AcademicMedicine #Research #StanfordUniversity

[Dr. Nina Niu Sanford @NiuSanford]

This is a great read on watch & wait in rectal cancer.

B/c patients with local regrowth after WW have higher rates of distant mets, there has been an intuitive fear that regrowth is causal (i.e delaying TME permits metastatic seeding hence WW risky).

The authors here argue (and I agree) that regrowth/metastases are manifestations of intrinsic aggressive tumor biology because:

1) no difference in time to surgery in patients w pCR/regrowth who developed mets vs. those who didn't (if delay were causal, would expect longer delay in patients who developed M1).

2) in OPRA secondary analysis, patients with cCR underwent least surgery/longest observation while those with incomplete response had surgery most frequently/immediately. But outcomes still tracked with response phenotype not timing of surgery (i.e. cCR did best).

3) tumor response itself is prognostic (i.e. even when all pts undergo TME, more regression after neoadjuvant therapy --> better DFS/DM).

4) modern tumor evolution data suggest metastatic spread mostly happens early.

5) chemo/radioresistance appears to be linked to metastatic potential (i.e. regrowth is a marker of aggressive biology not the mechanism itself).

IMO a persuasive argument against hypothesis that regrowth seeds metastasis, but rather biology=dominant driver. @OncoAlert

[Fahima Dossa, MD PhD @fdossa]

@NiuSanford Thanks for this great summary of our work!

[Fahima Dossa, MD PhD @fdossa]

Thrilled to finally see this out - 🚨#Sarculator bayesian update for more refined risk estimates in extremity soft tissue sarcoma

App📱update and @LancetOncology pub: https://t.co/MU01O5h5ca

Phenomenal work @DCalleMD, Gabriele Tine, et al. ! 👏🏽👏🏽

[Dario Callegaro @DCalleMD]

The #Sarculator app update is now live!
This comes together with our @TheLancetOncol paper introducing #BayeSarc, a Bayesian sequential learning approach to refine prognostication in extremity soft tissue #sarcoma.
Paper: https://t.co/gQuFERjCqu
App: https://t.co/4mLSfv7zE3

[Fahima Dossa, MD PhD @fdossa]

@jgong15 @JCO_ASCO Thanks so much!

[Fahima Dossa, MD PhD @fdossa]

With ⤴️use of W&W for rectal cancer, how can we safely 🫸the limits? Is there a role for W&W in pts with *near* complete response or does this risk distant disease?

More on the📊 and our recommendations for safe W&W practices: https://t.co/SrxoUVZFcQ

@JCO_ASCO @DrGarciaAguilar

[Fahima Dossa, MD PhD @fdossa]

@DanielleHammo20 @HannahRAbrams Spider/radar diagram

[Fahima Dossa, MD PhD @fdossa]

@HannahRAbrams Thanks for highlighting! This is probably clearer in the paper but we purposely framed all outcomes such that further from center = better (eg tolerability rather than toxicity)

So niro had ⬆️toxicity (incl ovarian suppression) but most rapid effect💨(?differences in study pops)

[Fahima Dossa, MD PhD @fdossa]

New RCT data 📈 supporting the efficacy of Doxil for progressing desmoid tumors. Now 3 options supported by level 1 data - but how to choose? 🧐

👀 editorial in @CCR_AACR with @SilviaStacchia and @alegronchi

https://t.co/pDLiZK0fX7

[Fahima Dossa, MD PhD @fdossa]

@jgong15 @NIH @theNCI @ConquerCancerFd @TowerCancer @CSCancerCenter @crisbergerot @PauloBergerot @CParkMD @montypal @NazliDizman @ASCO @NIHFunding @MOASC_Office @nataliagandur Congrats!!👏🏽 🥳

[Fahima Dossa, MD PhD @fdossa]

Congrats @seacm! 👏🏽 👏🏽

[Jackie Garonzik Wang @garonzikwang]

Celebrating @seacm on receiving the AHPBA Research Development Grant. This is the impact we strive for: advancing science, elevating care and leading the way.

https://t.co/ZPkzAodCsP

[Jun Gong, MD @jgong15]

Great way to cap off #colorectalcancer awareness month hosting our @CSCancerCenter #CRC research social w/Dr. Alessio Pigazzi @EdwinPosadasMD for a productive exchange of ideas, networking & future collabs w/PhDs & MDs in #CRC research @AGangiMD @fdossa @SGrivennikov @SekiEki

[Fahima Dossa, MD PhD @fdossa]

@drohan_ashley 🙏🏽