Tumor-Agnostic Precision Medicine from the AACR
GENIE Database: Clinical Implications
@CCR_AACR
https://t.co/OPrwZzekv4
👉Distribution of 5 tissue-agnostic targets with FDA approval among different cancer types : BRAFV600E, RET & NTRK fusions, TMBhigh & MSI
@myESMO
We close @eventsWCS#CanGenAnalysis23 with presentations by participants! All teams had to analyse TCGA data from different #cancer types and present its drivers, oncoplots, mutational signatures and clinical correlations. I think it was a success! 😀😀
Accumulative publications showing that immunotherapy is more potent when given early in the day. Time to change our practice and give our IOs in the morning? At least until evidence of a circadian biology supporting the hypothesis & availability of data from phase III trials?
Pembrolizumab in Patients With Tumors With High Tumor Mutational Burden: Results From the TAPUR Study
@JCO_ASCO
https://t.co/BUdhRmTwV9
👉efficacy, but only moderate association btw TMB and ORR, PFS, & OS
👉TMB alone is insufficient to predict benefit from ICIs
@myESMO@OncoAlert
Pan-KRAS probe compounds BI-2865 and BI-2493 active against a broad range of oncogenic #KRAS variants that selectively inactivate downstream signaling and tumor growth, while sparing NRAS and HRAS. Now in print @nature#openaccess#precisiononcology
https://t.co/40IZvE0O5E