Do we study the right biology after myocardial infarction (MI)?
• Surgery in standard mouse model masks MI-specific immune responses
• Minimally invasive model better reflects patient immune responses & reveals immature neutrophils worsen heart function
https://t.co/MIDaP9lSgs
Please join us for our 2nd Immuno-Cardiology Symposium in beautiful Bar Harbor, Maine, Sept. 18-19! @jacksonlab@MDIBL explore how dysregulated immune system function contributes to inflammation and fibrosis in disease and related disorders in the kidney, lung and liver
Sicklinger & colleagues developed a new #ultrasound-guided method to induce #HeartAttacks in mice, allowing precise control & real-time monitoring without the need for invasive surgery. Learn more at https://t.co/yqrOd4AS7o
@volkersmirko@junedh_amrute@rkramann
In @Nature we use single cell multiomics, fibroblast fate tracing, and in vivo models to characterize immune fibroblast crosstalk in heart failure with @LavineLab @washumedicine, @Amgen , and @ImmunoFibHF https://t.co/xyzLItDYmk
Check out our paper just published in Circulation
➡️ Translation controls inflammation after myocardial infarction
https://t.co/xWORVd0MKd
This work was a huge collaborative effort over many years.
@dzhk_germany@DGK_org@VolkersMirko
Key findings + paper summary below 🧵⬇️⬇️⬇️
Very happy that our manuscript is now online @CircAHA. Transient inhibition of translation protects against #reperfusion injury. Kudos to first author @ChrlsHofmann and to all Co-authors for a great team effort. @CRC1550@dzhk_germany@uniklinik_hd https://t.co/Ormsibt4ul
Read my Tools of the Trade article, published in @NatRevCardiol, highlighting my experience with and the method of ultrasound guided induction of myocardial infarction:
https://t.co/GNFn4rSA3L
Thanks to @FloSicklinger & F. Leuschner for developing such an innovative method.
A shortcut to the infarcted heart
Excited to share our collaborative effort with @DenisSchapiro lab led by @FloSicklinger and @FloWuenne. Using spatial omics technologies, we found a new way how monocytes sneak into the infarcted heart.
https://t.co/cOO80X7L9M