Freddie Partridge

Lecturer in Cell Biology at the University of Westminster. Interested in genetics, protein misfolding diseases and parasites.

[Freddie Partridge @fpartridge]

Our new paper (and 1st since I joined @LifeSciWestmin ) on drug repurposing for the neglected human infection whipworm, with Avril Coghlan @Berriman_mb4 @mariaduco @gr10_rinaldi : A drug repurposing screen for whipworms informed by comparative genomics https://t.co/PUdmb4NaTq

[Freddie Partridge @fpartridge]

@ponganer @LifeSciWestmin @Berriman_mb4 Oh no twitter seems to have broken the link. I'm sure it was working when I posted it...

[Freddie Partridge @fpartridge]

Happy to share my first preprint since joining @LifeSciWestmin. Lead by Avril Coghlan and @Berriman_mb4 (Sanger, Glasgow) we used comparative genomics to predict drugs with potential for repurposing against whipworm infection

https://t.co/exSQ1mOVlr

[Freddie Partridge @fpartridge]

Really appreciate the clear statement and advice from @AddisonsUK clinical panel regarding vaccination priority groups for Addison's disease - very helpful

[Addison's Disease Self-Help Group (ADSHG) @AddisonsUK]

Links are inc in our "Coronavirus Vulnerable Adult Advice" statement by the Addison's Clinical Advisory Panel 👇

This gives you the info to pass onto your medic, so they have more details about providing you with an emergency hydrocortisone injection.
https://t.co/Lg5sEkzaT9

[Freddie Partridge @fpartridge]

Really recommend this new paper from @_JamesIrving_
- very impressed by the creative way that it integrates many different techniques (EM, SAXS, crystallography) and datasets by using modelling to assess which antitrypsin polymer structure fits best with the evidence

[James Irving @_JamesIrving_]

Our paper is out - to address the question of the structure of alpha-1-antitrypsin polymers in a person who carries two copies of the Z allele, we went to the source: the liver itself. #antitrypsin #A1ATD @UCLRespiratory @ismb_london @AlphaFriend https://t.co/SxBQdoAyBq

[Freddie Partridge @fpartridge]

Our new preprint on screening methods for mosquito larvicides and detecting resistance - even with a mobile phone - with Steve Buckingham @QM_SBCS, @Beth_Poulton
and @LSTM_VectorGene from @LSTMnews and Ben Miller and Rachel McKendry from @isenseIRC
.

[bioRxiv @biorxivpreprint]

Automated phenotyping of mosquito larvae enables high-throughput screening for novel larvicides and smartphone-based detection of larval insecticide resistance https://t.co/VEhc0mu4vV #bioRxiv

[Freddie Partridge @fpartridge]

From a special issue in @BeilsteinInst #BJOC on open science in chemistry organised by @MatToddChem who is part of the pioneering @O_S_M team doing such great work for malaria. Would be really great to set up a similar Open Science programme for neglected helminth diseases! (3/3)

[Freddie Partridge @fpartridge]

Our new #bjoc review article on Open Science and anthelmintic drug discovery. With @kathelse @ruthaforman from @LydiaBeckerIII and @AJR_group Carole Bataille and @wynner71 from @OxfordChemistry. https://t.co/TX4q3rVdLt We assess the state of the anthelmintic field, (1/3)

[Freddie Partridge @fpartridge]

highlight many open-source screening methods and genomic tools and also discuss the success of open drug discovery initiatives such as the @MedsforMalaria Pathogen Box (2/3)

[Freddie Partridge @fpartridge]

@BoronChem @ACSCatalysis @SheffieldChem First of many! Congratulations to both!

[Freddie Partridge @fpartridge]

Our @UCLRespiratory PhD students Anwen Brown and Emma Elliston presenting their images at the @ucl Reseach Images as Art/Art Images as Research competition

[Freddie Partridge @fpartridge]

Our concert coming soon! Also J. Rathbone ‘Seven last words’ https://t.co/QitGjBU1lr https://t.co/l7qZpIIZKn

[London Forest Choir @ForestChoir]

Conductor meets composer. Christopher Wood dropped in to hear us rehearse his Holy Week. Luckily he liked what he heard! We’re all ready for its debut performance on 1 April in Waltham Abbey.

[Freddie Partridge @fpartridge]

Our paper on fast screening methods for parasitic worms and C. elegans with @ruthaforman @kathelse @ProfJBMatthews is now published https://t.co/vQq4pk3Lyj Includes screening of the great open science Pathogen Box from @MedsforMalaria All code free to use https://t.co/UsgUIIwwlH

[Freddie Partridge @fpartridge]

Technique with a lot of potential for 3D imaging of parasites within host tissue https://t.co/nLt32yMDEA

[Apyx Risk Curator @ApyxRisk1]

our paper exploring the potential of xray tomography for understanding parasite biology is out now with @kathelse and @ProfAndrewMac https://t.co/6rlwdcDsZp

[Stanford Pathology @StanfordPath]

Trichuris trichiura (whipworm) seen in cross section with numerous eggs on the GI biopsy service #pathology #whipworm #trichuristrichiura

[Current Biology @CurrentBiology]

Meet the #nematode Diploscapter — millions of years without sex & entire #genome packed into a single chromosome https://t.co/OhunGTxsR4

[Freddie Partridge @fpartridge]

Our new preprint on screening methods for parasitic worms and C. elegans. Collaboration with @kathelse @ProfJBMatthews @AJR_group https://t.co/0TXccVwkHO

[bioRxiv @biorxivpreprint]

An automated high-throughput system for phenotypic screening of chemical libraries on C. elegans and ... https://t.co/jxinAXcdE8 #bioRxiv

[Freddie Partridge @fpartridge]

Also encouragingly high cure rate (68.5%) with albendazole/oxantel pamoate combination for whipworm

[Freddie Partridge @fpartridge]

Important trial supporting the use of new drug combinations, hoping to delay the occurrence of resistance due to mass drug administration https://t.co/fOEMZjosjT

[The Lancet Infectious Diseases @TheLancetInfDis]

New online: Tribendimidine alone or in combination vs albendazole plus oxantel pamoate against #hookworm and #STHs https://t.co/sx7lS318nU

[The University of Manchester News @UoMNews]

New drug developed by @kathelse & colleagues destroys parasite that infects 500m people https://t.co/AfPVRahOK3