Wouter Franssen

Postdoctoral Research Fellow interested in sedentary behaviour, physical activity and cardiometabolic health

[Pablo Corral MD @drpablocorral]

👉Cardiometabolic Disease: The Silent Pandemic We Keep Underestimating

1️⃣ Kills ~20 million people every year worldwide — twice as many as all cancers combined.
2️⃣ Accounts for ~31% of all global deaths, compared with ~16% for cancer.
3️⃣ Often strikes suddenly and without warning, frequently outside the hospital and before a diagnosis is ever made.
4️⃣ Cardiovascular disease, diabetes, and chronic kidney disease progress together, damaging multiple organs simultaneously.
5️⃣ The disease develops silently over decades, making prevention and early intervention essential.
6️⃣ The annual global economic burden exceeds US$4.7 trillion, nearly 4 times greater than that of cancer.
7️⃣ The greatest opportunity in modern medicine is not treating late disease—it’s identifying high-risk patients early and preventing the first event.
8️⃣ A patient-centered cardiorenometabolic approach has become one of the most important public health priorities of our time.

☝️Bottom line:
Cardiorenometabolic disease is not just the leading cause of death—it is the leading cause of lost healthy life and healthcare costs worldwide. Prevention can no longer wait.

@society_eas
@nationallipid
@escardio
@fhpatienteurope
@ACCinTouch
@AHAScience

[SportsCardiology @Sports_CardioNL]

Refined physical activity recommendations considering cardiovascular disease risk stratification: a cohort study
https://t.co/bsuTGOCVaW
#CVD #physicalactivity #riskstratification #Sportscardiology

[Christoph Burch @ChristophBurch]

Role of Physical Activity in Obesity Treatment and Cardiometabolic Health: A Scientific Statement From the American Heart Association
https://t.co/zg2Ao3WND5

[Christoph Burch @ChristophBurch]

Physical activity and the brain barriers: Mechanisms of neuroprotection and disease resilience
https://t.co/UgC05yKrup

[Aitor Viribay @MVAitor]

“Exogenous lactate” field is heating up - it seems!

Check the latest paper published by George Brooks, father of modern lactate understanding, addressing the main gap in Exogenous Lactate administration: exogenous delivery.

Molecular vehicles of Lactate: https://t.co/hSfXFyi3rz

[Agingdoc🩺Dr David Barzilai🔔MD PhD MS MBA DipABLM @agingdoc1]

Physical activity for public health in the 21st century

https://t.co/8wRfe2lPtE

[Eric Topol @EricTopol]

Our best shot for preventing many diseases?
Exercise
A @Cell_Metabolism new review
https://t.co/axi6aUDpZ7

[ProPASS Consortium @ProPASSconsort]

See the latest report from the WHO meetings on integrating wearables into global physical activity surveillance, available to read online now:
https://t.co/jRYFyGN733

[ProPASS Consortium @ProPASSconsort]

New evidence on short-bursts of activity and lower type 2 diabetes risk among non-exercises: A clear dose–response. Even ~4 min/day of vigorous intermittent lifestyle activity (VILPA) is linked to ~36% lower type 2 diabetes risk [1/2]
https://t.co/LDjv2bvtY0

[Christoph Burch @ChristophBurch]

Efficacy of Exercise-Based Interventions for Metabolic Syndrome: An Umbrella Review With Meta-Analyses
https://t.co/90lN9ogxAO

[Asker Jeukendrup @Jeukendrup]

This paper from the UCI project sports nutrition for road cycling is now available! https://t.co/6n8Bj96jes
I posted a summary here: https://t.co/coa452kQRG

[Aitor Viribay @MVAitor]

Exogenous Lactate - effects on Fat Oxidation and Glycogen Synthesis.👇🏼

Very interesting study carried out in rats:

“… lactate supplementation may increase fat utilization as well as induce positive effects on glycogen synthesis in athletes.”

https://t.co/Ys9WWKD9G7

[David Bishop (🦋 also bluespotscience.bsky.social) @BlueSpotScience]

Exercise training induces mitochondrial biogenesis, while high-fat diet increases the ability of mitochondria to use long and short-chain fatty acids https://t.co/wVNqbOeTi0

[David Bishop (🦋 also bluespotscience.bsky.social) @BlueSpotScience]

Serum metabolomic signatures for high-, moderate-, and low-intensity exercise.
https://t.co/v2rfOQKPXu

[Nick Krontiris @nick_krontiris]

Once again shedding doubt on the concept of “metabolically healthy obesity”, this one found that children aged 7 to 17 years with metabolically healthy obesity have an increased associated long-term risk of type 2 diabetes, hypertension, and dyslipidemia compared with their peers in the general population.

[Nick Krontiris @nick_krontiris]

In this study, a 12-week multiple behaviour change intervention aimed at reducing sedentary time was associated with modest improvements in cardiac autonomic function, muscle oxidative capacity and functional exercise capacity, improvements that were largely linked to increases in moderate-to-vigorous physical activity.

[David Morales-Álamo @D_Morales_Alamo]

New in @Cell_Metabolism : Lactate isn’t waste—it’s a key circulating fuel, tightly regulated between production and clearance, essential for whole-body energy balance.

https://t.co/siUTsQgYmI

[Christoph Burch @ChristophBurch]

Crosstalk between skeletal muscle and the brain during physical activity - in search of epigenetic mechanisms
https://t.co/JvxDaGGKoZ

[EHJ Editor-in-Chief @ehj_ed]

Volume vs intensity of physical activity and risk of cardiovascular and non-cardiovascular chronic diseases. Read more in the @EHJ at https://t.co/0huJxbCxZa #PhysicalActivity #CardiovascularHealth #ExerciseScience @ESCardio @ESC_Journals

[Trends in Endocrinology & Metabolism @Trends_Endo_Met]

Online Now: Palmitic and oleic acids in type 2 diabetes mellitus https://t.co/R4yNPngqYL #trends #endocrinology #metabolism