Frydman Lab

A lab at Stanford University studying protein biogenesis, folding, and aggregation in health and disease. Tweets by lab members.

[Frydman Lab @FrydmanLab]

Another great story from Jae Ho Lee in the lab: a new concept in cotranslational proteostasis-ribosome communication via chaperoneNAC. An exciting collaboration with Elke Deuerling's lab @DeuerlingLab and Marina Rodnina's lab https://t.co/XF7wlCrr5W

[Frydman Lab @FrydmanLab]

New exciting work from Jae Ho Lee in our lab, in a fantastic collaboration with Alessandro Ori @AOri_lab and Alessandro Cellerino @Alessan82703458 on why and how the brain ages and becomes vulnerable to neurodegenerative diseases https://t.co/sVQRO43tZo

[Anshul Kundaje @anshulkundaje]

Paging @NIHDirector_Jay . Is abruptly cutting these grants going to "make America healthy again"?

[Nature Metabolism @NatMetabolism]

Triglycerides are an important fuel reserve for synapse function in the brain https://t.co/CGh06mwETW

[John Maraganore 🇺🇸🇬🇷🇺🇦 @JMaraganore]

I stand with dozens of other biopharma leaders highlighting the potential catastrophic effects of proposed research cuts on bringing innovation to patients! https://t.co/ZlDal4Euug

[John Streicher @JohnStreicher1]

My NIDA grant renewal is almost 2 months late and I’m going to have to start firing my students and staff. Not a lot of transformation to be had in my lab.

[Eran Segal @segal_eran]

Our lab at the Weizmann Institute was hit tonight by Iran

We will rebuild and return 💪

[Frydman Lab @FrydmanLab]

@JSheltzer Such great news!
Looking forward to many opportunities to collaborate and discuss science

looking

[Frydman Lab @FrydmanLab]

@SergioCruzLeon1 @jpkreysing @MarinaLusic @Beck_Laboratory @MPIbp This is incredible! So incredibly cool and important. Congratulations!

[Frydman Lab @FrydmanLab]

@SamantLab Congratulations! Being a fellow Luddite myself I commiserate, but don't miss the irony I do so on social media. Looking forward to many more PhD thesis to come from your lab!

[Piere Rodriguez-Aliaga @PiereBiophysics]

It was a pleasure to participate in the "Protein folding & Chaperones" platform session this morning in #bps2025 sharing our story from the @FrydmanLab about TRiC mutations and their link with brain malformations. A session with a nice mix of cool stories focused protein folding

[Fabián Morales-Polanco @FaboPolanco]

Closing an unforgettable chapter at Stanford. Grateful for the science, the growth, and the incredible people who shaped this journey—especially Judith, with whom I had the privilege of doing great science. This place and its people will always mean a lot to me. Very excited!

[Frydman Lab @FrydmanLab]

@nmr900 @LEK_Lab @UofT @EASorg December 4 Webinar | 10 a.m. - Noon EDT via @ProteinSociety https://t.co/8iOxb5wyYo

Congratulations on this super deserved award!

[Frydman Lab @FrydmanLab]

@HuaipengXing @Beck_Laboratory @goetheuni Congrats Dr Xing! A brilliant future awaits!

[Frydman Lab @FrydmanLab]

3) Two surprises that could only be revealed by cryoET raise new cool future questions (I) It uncovered a new cofactor, PDCD5 which binds to ALL open TRiC complexes (and was missed by biochemical studies) and (II) closed TRiC forms stereotypic clusters of mysterious function.

[Frydman Lab @FrydmanLab]

2) The MS also quantified TRiC-Prefoldin cooperation in vivo. Importantly it establishes that closed TRiC engages in specific interactions with quasi-folded substrate folding intermediates in its closed folding chamber, which is clearly NOT an "Anfinsen cage"

[Frydman Lab @FrydmanLab]

Check out our MS describing the in vivo cycle of chaperonin TRiC/CCT, in a wonderful collaboration with Martin Beck's lab: https://t.co/0d2O9smiMF
1) The study established TRiC's important function in folding newly translated proteins and defines its ATP-driven cycle

[Frydman Lab @FrydmanLab]

@Beck_Laboratory @HuaipengXing @Nature Congratulations Huaipeng and Martin for this super-exciting collaboration and to all of the Beck lab for the warm welcome and hospitality during my sabbatical in Frankfurt last year! Not every day one discovers a new major chaperone cofactor, and from cryoET density no less.

[Frydman Lab @FrydmanLab]

A really nice piece on our recent study: https://t.co/eFsAcSHx6m

[Frydman Lab @FrydmanLab]

@CAMBUpenn @ErikaHolzbaur what a great paper!