We have a new Clinical Notice recommending against ivermectin & fenbendazole for cancer treatment outside of clinical trials.
Read more: https://t.co/zuzM9uffuu
#ScienceSaturday
❓ Why do some cancers keep dodging our best immune therapies?
➡️ Scientists have discovered a trick tumors use: they decorate their surface with special sugars (called glycans) that act like “invisibility cloaks,” shutting down immune cells through receptors called Siglecs.
➡️A recent study published in @Nature Biotechnology introduces an innovative strategy to counter this effect: antibody–lectin chimeras (AbLecs). These engineered molecules are designed with dual functionality:
- One component selectively binds to cancer cells
- The other disrupts glycan-mediated inhibitory signaling
➡️As a result, immune cells such as macrophages and natural killer (NK) cells regain and enhance their tumor-killing activity. In preclinical mouse models, AbLecs demonstrated superior tumor reduction compared with standard antibody therapies.
➡️ Bonus: AbLecs can be customized to target different cancers and even combine two immune checkpoints (like PD-1 and Siglec) in one molecule. This could open new doors for patients who don’t respond to current immunotherapies.
🌟 Huge kudos to Jessica Stark, Carolyn Bertozzi, and their teams at MIT, Stanford, Rockefeller University, and collaborators for this breakthrough in cancer immunotherapy! @JessicaCStark@MIT@Stanford@RockefellerUniv@NatureBiotech
Read more: https://t.co/MiMdg4uh1s
A new internal checkpoint!
TAK1 helps cancer cells survive T cell attack.
Block TAK1, and immune therapy works better!
@CellReports@OncoAlert@ONCOassist
https://t.co/jea9xqDLkW
Congratulations to Deb Schrag, MD, MPH, FASCO on being elected to serve as ASCO President for the 2027-2028 term! Dr. Schrag will take office as President-Elect after the #ASCO26 Annual Business Meeting.
Learn more about additional elected members: https://t.co/AFIw7J27Ud
The @US_FDA approved a combination of two drugs — enfortumab vedotin and an immunotherapy drug pembrolizumab, to be given before and after surgery for people with muscle-invasive urothelial carcinoma — a cancer that usually starts in the bladder and can also appear in other parts of the urinary system.
MSK genitourinary oncologist Dr. Rosenberg has led multiple clinical trials testing enfortumab vedotin alone or in combination with others for #bladdercancer. Learn more ⬇️ https://t.co/AqMsWmJVTS
And the mystery speaker is...
Stephen Fry!
We’re thrilled to announce this latest addition to The Festival of Genomics and Biodata agenda. Stephen will take part in a Fireside Chat with Vivienne Parry. Find out more on our website: https://t.co/86wpyNaSA2 #FOG2026