Giulio Chiesa

research associate in @GartonLab, former @MoKhalilLab: synthetic biology, protein design and vibes

[Oded Rechavi @OdedRechavi]

A PhD's success depends more on the fit between the student, the advisor, and the lab than on the specific topic being studied (it barely matters at all).

Similarly, a lab's success depends more on how excited (or miserable) its researchers are than on the precise project they are working on (it could be virtually anything).

This information isn't in papers or in grant proposals, you have to ask the researchers.

[Giulio Chiesa @gchies1]

@kenbwork Good post but mentioning complex techniques aas “you just do a perturb-Seq” seems to me a bit dismissive of the complexity each techniques involved. Beside their cost. There is a hidden cost of complexity I.e. how much trial/error and experience it takes to ace the experiment

[Giulio Chiesa @gchies1]

One of the most satisfying ways to use Claude is to ask for help troubleshooting something, explain in detail what the problem is, figure out the solution and delete the prompt.
Zero tokens!

[Giulio Chiesa @gchies1]

@DdelAlamo It costs a fortune!! $$$

[Giulio Chiesa @gchies1]

Opinions on the best disorder predictors in 202*? Using PONDR and DisEMBL makes me feel old 😬
Hey I love them, but they are from 20 years ago! #IDP #disorderedprotrins

[Bashor Lab @BashorLab]

We are pleased to share a paper from our lab out in this week’s issue of @Nature, where we show that HT + ML can dramatically speed up the synbio DBTL cycles, profiling gene circuit design spaces at unprecedented scale: https://t.co/7FwDVN4259 (1/16)

[Giulio Chiesa @gchies1]

[ENG post soon]
L’Ozempic spiegato ai miei

https://t.co/Bh8PyJEfK4

[Giulio Chiesa @gchies1]

Everybody who shows up at the FedEx office at opening on a Saturday of a long weekend has a story to tell. It generally involves *stress*!!

[Michael Baym @baym]

For those of you who aren't aware, cancelling Harvard's F and J visas does not just affect students. It also affects many, many postdoctoral researchers.

And critically, it affects OPT holders. These are graduates who stayed here to work in the US, they cannot "transfer"

[Giulio Chiesa @gchies1]

SynBio 7.0 and Bioengineering Conference is coming soon! June 1-3, 2025 at the University of Toronto! 🧬🇨🇦
Abstract submission open until May 2nd!
Submit it here: https://t.co/Vf2eD7QyJ8

Our keynotes: Dr. Nika Shabika Dr. Kevin Solomon, Dr. Benjamin Scott, and Dr. Adam Damry.

[Noémie @FedericoNoemie]

🧵New H1-B rule by Homeland Security

HUGE changes that align with policy goals to drive U.S. innovation, especially in STEM fields and AI.

[Katie Galloway @GallowayLabMIT]

Bringing neural networks to life | Science
It was fun to highlight the neat new work from @ZiboChen and @ElowitzLab in this highlight
Link below

[Giulio Chiesa @gchies1]

They all share a hydroxyl group

[Daddy Warpig @DaddyWarpig]

I hate this and I’m mad I didn’t make it.

[Jean-Baptiste Lugagne @jblugagne]

Excited to share that I will soon be starting a group at @UniofOxford in the Dept of Engineering Science. We will focus on data-driven methods for cell-machine interfaces, with applications in biomanufacturing, biomaterials, fundamental biology research, and more

[Giulio Chiesa @gchies1]

@JessicaSacher We have either a space for laptops or an old computer at each bench. Just enough to use OneNote and with internet access. It works for me, but might not for everyone.

[Giulio Chiesa @gchies1]

@JessicaSacher Very real! I also found slacking yourself (or telegram or other IM with the option of self-posting) helps, especially for those with electronic lab books.

[Giulio Chiesa @gchies1]

@A_BlanchAsensio Always cool work you guys!

[Katie Langin @k_langin]

"Postdoc positions can be exploitative."

My latest story—about a study showing that international postdocs in the U.S. are paid less and received less careeer support and guidance than U.S. citizens. #AcademicChatter #postdocs @ScienceCareers

https://t.co/TI3TSAXnYF

[Giulio Chiesa @gchies1]

Stellar! 😮

[Matthew Eroglu @matt_eroglu]

Why are so many inherited traits not explained by genome sequence variation? In my PhD work with @wbderry we describe a new mechanism of inheritance in animals that may account for this ‘missing heritability' 🧵https://t.co/K0tfW4PIoi

[Kresten Lindorff-Larsen @LindorffLarsen]

Our work on computational design of intrinsically disordered proteins is now out in Science Advances

We asked whether we could use molecular simulations and ML to design disordered proteins with specified properties of conformational ensembles 🍝

https://t.co/Q9tk46v9iO