Gestwicki Lab

The Gestwicki Lab @UCSF uses #chemicalbiology and #biochemistry to understand the #proteostasis network. This account is student run.

[Gestwicki Lab @GestwickiLab]

Proud to share this publication by our postdoc, Shweta Devi! It offers new insights into the interaction capabilities of the TPR domain to EEVD-like motifs in nonchaperone proteins.

https://t.co/fOcVT8Z9Y0

[Gestwicki Lab @GestwickiLab]

Excited to share the work done by @taiawu and Zach Gale-Day on DSFWorld: an online open-source software that streamlines the planning and analysis of DSF experiments!

https://t.co/T5g731xMfk

[Gestwicki Lab @GestwickiLab]

Interested in learning how dyes might help in characterizing protein activity?

We're excited to share the development of a protein-adaptive DSF platform (paDSF), a dye-based method used to interrogate stability, dynamics, and ligand binding!

https://t.co/uTANww2Vwc

[Laura Kiessling @ChemicalBiology]

First woman to graduate from MIT was a chemist. She applied chemistry to issues like nutrition - a pioneer ahead of her time in many different ways #WomenInSTEM

[Gestwicki Lab @GestwickiLab]

We’re thrilled to have Nick joining us!

[Scripps Research Graduate Program @ScrippsGradPrgm]

An alum of Prof. Jeff Kelly's lab, Nicholas Yan looks forward to a postdoc position in @UCSF's @GestwickiLab and @SouthworthLab, where he'll use cryo-electron microscopy to explore the structural basis of small molecules that target amyloid fibrils. More: https://t.co/uTCkTLIcza

[Gestwicki Lab @GestwickiLab]

@ChemicalBiology @KiesslingGroup Thank you!

[Gestwicki Lab @GestwickiLab]

Congratulations to our amazing postdoc @proteins_emma on winning a poster award at the Protein Folding Dynamics Gordon Research Conference!!! It��s a well-earned testament to her brilliance & creativity!

[Gestwicki Lab @GestwickiLab]

Huge congratulations to @CarolynBertozzi !!! What a well deserved honor.

[The Nobel Prize @NobelPrize]

BREAKING NEWS:
The Royal Swedish Academy of Sciences has decided to award the 2022 #NobelPrize in Chemistry to Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless “for the development of click chemistry and bioorthogonal chemistry.”

[QBI @QBI_UCSF]

As part of the #QBIChemBio22 Symposium today, @jadoudna, Nobel Laureate, co-inventor of #CRISPR-Cas9 & Professor at @UCSF/@UCBerkeley will participate in a Twitter Space hosted by Jason Gestwicki. Tune in at 1:30 PT to hear about her work!
https://t.co/Juigimzrqj

[Ziyang Zhang @bignerdzzy]

Jumping around the mutation alphabet to hit cancer! Our new work covalent targeting of KRAS G12S is online: https://t.co/GWj1Wzcugq Interested in more? The Zhang lab (https://t.co/Fm4hoDMWpP) at @UCBerkeley is recruiting:)

[Frydman Lab @FrydmanLab]

Chaperones are needed for so many processes! How do you make process-specific or disease-specific chaperone inhibitors that are not generally toxic? A great collaboration with @GestwickiLab shows the way...https://t.co/6DwCRX1WS8

[Gestwicki Lab @GestwickiLab]

Another great collaboration out today!

[Frydman Lab @FrydmanLab]

Chaperones are needed for so many processes! How do you make process-specific or disease-specific chaperone inhibitors that are not generally toxic? A great collaboration with @GestwickiLab shows the way...https://t.co/6DwCRX1WS8

[Arun Wiita @apwiita]

…and another 1! 2nd paper in 1 wk @idferguson. Collabo w @gestwickilab @CellChemBiol: allosteric HSP70 inhibitors overcome proteasome inhibitor resistance in #myeloma #mssm. #proteomics finds surprising mechanism: block HSPA9 & destabilize mitoribosome!
https://t.co/GGkkRBi4Zf

[Gestwicki Lab @GestwickiLab]

It was fun to be a part of this exciting work!

[Arun Wiita @apwiita]

…and another 1! 2nd paper in 1 wk @idferguson. Collabo w @gestwickilab @CellChemBiol: allosteric HSP70 inhibitors overcome proteasome inhibitor resistance in #myeloma #mssm. #proteomics finds surprising mechanism: block HSPA9 & destabilize mitoribosome!
https://t.co/GGkkRBi4Zf

[Ziyang Zhang @bignerdzzy]

I concur. I confirm that new PIs will do everything to make their mentees successful! I contend that other hashtags are also cool. I also confess that I’m a new PI @UCB_Chemistry and we are recruiting https://t.co/AVQsBE2WaO

[Matthew Ravalin @MatthewRavalin]

Happy to share the @biorxivpreprint for my first bit of work w/ @aliceyting. Together with @heegwangroh, we built a simple and versatile single-component luminescent biosensor for detecting the SARS-CoV-2 spike protein.
https://t.co/GPU8D4MwlA

[Gestwicki Lab @GestwickiLab]

@StressCell Thank you!

[Gestwicki Lab @GestwickiLab]

Check out our latest review article on non-canonical Hsp70 interactions—out now in Cell Stress & Chaperones! With the recent explosion of studies mentioning them, @oletaknowsstuff & Jason thought this timely. We hope it inspires new important research! https://t.co/cOsNn1v7J0

[Gestwicki Lab @GestwickiLab]

@MartinUCSF @tauCWOW @SinaiBrain @GeschwindLab @dlswaney @grinberg_t @timschang @TheBiocheminist Congratulations!!!

[Martin Kampmann @MartinUCSF]

Excited to co-direct the Tau Center Without Walls @tauCWOW with Alison Goate @SinaiBrain and @GeschwindLab, working with awesome colleagues @dlswaney @grinberg_t @timschang @TheBiocheminist and wonderful trainees!