Petros Giannikopoulos

[Anshul Kundaje @anshulkundaje]

If it's isn't obvious already, it is the end of papers as a measure of productivity, expertise or accomplishment. The odds of publishing in "glam" conferences & journals also very quickly approaches random & the time for gate keeping review increasing exponentially. 1/

[Michael 英泉 Eisen @mbeisen]

US biomedical science is way too self-congratulatory. Yes, we've made amazing progress in many areas. But after receiving nearly a TRILLION DOLLARS in federal funds this century, significant progress is a MINIMAL EXPECTATION - not some miraculous gift to society. The field in so many ways overpromises and underdelivers. If we want this kind of public investment for another quarter century, we can't just say "look how much we've done, give us more money!", we have to ask how we can restructure ourselves to optimally - not just marginally - deliver on this investment and trust, and then actually carry though in making the fundamental changes that will accomplish that.

[NEJM @NEJM]

Original Article: CRISPR-Based Therapy for Hereditary Angioedema (phase 2 trial) https://t.co/gvFbB2rTQF

Editorial: A Milestone for Gene-Editing Therapies https://t.co/dqXZFuKEUh

#Oncology

[Brigham and Women's Pathology @BWHPath]

We are heartbroken. Together we share our sorrow with the pathology and sarcoma communities, and with all who deeply admired and were inspired by Dr. Fletcher. In Memoriam: https://t.co/QhznOo2z22

#CDMF #Pathology #Pathologists #BSTPath #PathTwitter #PathX #Sarcoma

[Elon Musk @elonmusk]

What are the odds? 😂

[Fyodor Urnov @UrnovFyodor]

The @igisci is working to develop a suite of #CRISPR cure companion diagnostics in our CAP-accredited CLIA lab for high complexity molecular testing directed by @giannikopoulosp, MD.
The resulting laboratory developed tests will be widely available to the community.

[David R. Liu @davidrliu]

Today we report in @NatureComms the development of laboratory-evolved CBE6 cytosine base editors that offer high on-target C•G-to-T•A editing, virtually no A•T-to-G•C editing, low off-target editing, broad sequence context compatibility, and compatibility with multiple Cas domains.
/1

[Petros Giannikopoulos @giannikopoulosp]

@UrnovFyodor We used to call it 'man-to-man'

[Fyodor Urnov @UrnovFyodor]

My emotional COI here is taller than the Burj Khalifa.
With that disclosure:
https://t.co/uWfL0fyKBu
behold beautiful work by the brilliant @JRo_Hamilton @doudna_lab @igisci on what I personally think will be THE paradigm for immune system genome editing for both oncology and other disease indications.

[Fyodor Urnov @UrnovFyodor]

What does an "Avengers Unite!" team to build CRISPR Cures look like?
As @leilei_wuu @endpts explains ...
https://t.co/eQJ72S2mjD
... this requires
1- editing experts @igisci @berkeleyMCB:
@doudna_lab @giannikopoulosp and yours truly.
2- world-leading clinicians with deep expertise in treating patients with devastating disease: Jennifer Puck and Mort Cowan (ARTEMIS-SCID) and Michelle Hermiston (HLH) @UCSFMedicine.
3 - physician-scientists at @igisci @UCSFHospitals to lead the nonclinical work: @matthewjkan and David Nguyen.
4 - golden-handed wizards of manufacturing edited cells: @Kohn_Lab @UCLAHealth and @brshy @UCSFHospitals ...
5 - ALL of this multiplied by the might of @DanaherCorp R&D in Aldevron, IDT, Cytiva, Beckman Coulter Life Sciences, Leica Biosystems, and Leica Microsystems!!
#HealthJustice

[Chris Bakke @ChrisJBakke]

Sam Altman showing up to his office as CEO of MicrosoftAI and remembering that he has to use Microsoft Teams

[Mark Lewis, MD, FASCO @marklewismd]

Trust me, you do NOT want to catch them all

[Rowan Cheung @rowancheung]

This is the first robot that I've seen that could actually replace many warehouse workers.

Made by the Germans, of course.

[Michael 英泉 Eisen @mbeisen]

There is no excuse for having such a system.

[Jungsu Kim @jungsukim77]

😲 Time to revise textbooks 🤔
Title: "Transcription factors interact with RNA to regulate genes"

"at least half of TFs also bind RNA, doing so through a previously unrecognized domain"
https://t.co/Tql32vXfct

[Eric Topol @EricTopol]

When the #AI diagnoses a heart attack better than expert clinicians
via ECG in >7,000 consecutive patients across multiple US sites
https://t.co/LTwrGPTxGn
@NatureMedicine by @al_zaiti and colleagues

[Massimo @Rainmaker1973]

21-year-old Max Park has set a new world record for solving a 3x3x3 Rubik's Cube in just 3.13 seconds.

[his previous records: https://t.co/xUWAQ2v6HN]

[Nature Biotechnology @NatureBiotech]

Can microbes save the planet?
Genetic engineering and accelerated evolution of microbes aim to help climate change https://t.co/42iihnUjbd