Gokhan Cucun

Postdoctoral Researcher at Karolinska Institutet, Neurobiologist

[Atilgan Yilmaz @Atilgan__Yilmaz]

We are looking for a highly motivated PhD candidate to work in my group at KU Leuven, in close collaboration with the group of Prof. Ioannis Papantoniou. Please feel free to spread the word for the vacancy below.

https://t.co/rwBBDrGh2Q

[Science Magazine @ScienceMagazine]

A species of lungfish found in South America has claimed the title of the animal with the biggest genome sequenced so far. ⁠
⁠
The DNA of Lepidosiren paradoxa comprises a staggering 91 billion chemical letters or “bases,” 30 times as many as the human genome, researchers reported in Nature in 2024. However, those 91 billion bases of DNA only contain about the same number of genes that humans have—roughly 20,000—with the rest consisting of noncoding, perhaps even “junk” DNA. ⁠
⁠
By comparing this genome with those of other lungfishes, the researchers determined that L. paradoxa adds the equivalent of a human genome to its DNA every 10 million years.⁠

Learn more on #DNADay: https://t.co/QekhKNSOzY

[Neuron @NeuroCellPress]

Online now: Enhancer dynamics and cellular architecture in the human spinal cord https://t.co/QIMSgG5W5J

[Sergiu P. Pasca @Sergiu_P_Pasca]

Perspectives in @ScieMagazine after our Asilomar conferences on neural #organoids and #assembloids

https://t.co/pl0i386vH9

[Sergiu P. Pasca @Sergiu_P_Pasca]

Our latest work is out today in @ScienceMagazine: a self-organizing system that models organizer-driven patterning and commissural axon guidance in human neural development.

This was achieved with human midline #assembloids by combining floor plate and spinal cord #organoids from pluripotent stem cells.

A key advance is the three-part configuration (a floor plate squeezed in between two spinal cords), which enables human axons to cross the midline (and the subsequent synchronization of activity between the two parts seen in the video below).

This platform opens the door to many applications; here, we used it to screen and identify human-enriched midline crossing regulators.

Work led by @massimo_onesto with Neal Amin

[Ali Max Erturk @erturklab]

We have developed DELIVR, a user-friendly deep-learning pipeline for automatically detecting and analyzing cells from whole-brain images to map neuronal activity via cFOS. DELIVR uses virtual reality to substantially accelerate the generation of training data and is accessible to biologists without advanced coding skills through a simple Fiji plugin.

Kaltenecker, Al-Maskari, Negwer...Ertürk, Nature Methods. (Virtual reality-empowered deep-learning analysis of brain cells. 2024; doi:10.1038/s41592-024-02245-2)

@Dorie00
@Rami96614090
@moritz_negwer

#AI #Neuroscience #DeepLearning #VirtualReality #BrainMapping #ImageAnalysis #ComputationalBiology #CancerResearch #cFos #Fiji

[Shayan Shamipour @ShamipourShayan]

📣 Symposium 2050 at the University of Zurich

Join us for this event exploring emerging directions in life sciences, presented by a diverse group of leading experts.
Free and open to all! More info/register:
https://t.co/PStH1Ob3Ya

[ShorterLab @ShorterLab]

Neuronal aging causes mislocalization of splicing proteins and unchecked cellular stress: https://t.co/lR7iwXnBfP

[Xuyu Qian @QianXuyu]

Today in @Nature, we report a spatial single-cell atlas of human cortical development, revealing surprisingly early specification of human cortical layers and areas.
We built an interactive browser to explore the spatial data: https://t.co/Xy3JcsSpYw
Paper link below👇

[Ali Shariati علی شریعتی @Ali__Shariati__]

We’re living through pretty unusual times, but we’re excited to share good news! Our CRISPRa-programmed #embryo model paper is out! Thanks to our amazing group @glodewijk_sci @sayakakozuki and collaborators. I hope the community finds this model useful for new discoveries #CRISPR

[Claire Wyart @ClaireWyart]

A great school to learn the finest all optical experiments from the @EmilianiLab and world experts on in vivo single cell manipulation at ms resolution, voltage population imaging and more : sign up now to secure your spot!

[Madeline Lancaster @mad_lancaster]

I really enjoyed writing this Perspective for the special issue on Neuroscience. It's an exciting time to study the human brain!
Unraveling mechanisms of human brain evolution: Cell https://t.co/6bNN3Eab4u

[Sergiu P. Pasca @Sergiu_P_Pasca]

Our newest work is online now in Neuron @NeuroCellPress showing the generation of diencephaluc #organoids, assembly to form cortico-thalamic #assembloids and their application to discover defects following loss of function and gain of function mutations in CACNA1G, which are associated with high risk for schizophrenia and absence seizure epilepsy, respectively.

Work spearheaded by Ji-il Kim, Yuki Miura and @Minyin_Li

[Skirmantas Kriaucionis @sk_kriaucionis]

Cost of having DNA methylation: DNA replication by DNA polymerase epsilon is a source of C to T mutations in CpGs, especially methylated ones. This expands our understanding of one of the most widespread endogenous mutational mechanisms. https://t.co/V42N3MDEGG

[Caghan Kizil @CaKizil]

We're excited to share our new study on the role of the ABCA7 gene in brain resilience against #Alzheimer’s. Published in @CellGenomics, we found that ABCA7 is crucial for maintaining synaptic health by regulating #neuropeptide Y (NPY), a key molecule for brain communication and repair. Loss of ABCA7 reduces NPY, weakening the brain's defenses against AD.

By combining #zebrafish models, human datasets, and #patient-derived iPSCs, we discovered that ABCA7 variants impact synaptic integrity and brain function. Our study also highlights how Alzheimer mechanisms mechanisms vary across different ethnicities. Understanding ABCA7's role in diverse populations can help develop more targeted and effective treatments. By targeting #ABCA7 and boosting NPY signaling, future therapies could offer better protection against AD, giving us hope for new treatment strategies.

#Neurodegeneration #DiversityInResearch #HealthEquity #BrainHealth

Study Shows How Common Genetic Variants in Black Americans Increase Alzheimer’s Risk https://t.co/e0NcDvkqIN

[GDR ImaBio @GDR_ImaBio]

Save the date 7-8/10/2024 : GDRImabio will co-organize with @Fr_BioImaging a workshop on "High Resolution 3D Microscopy in Biology: Development & Applications", happy to welcome @JungmannLab @Sciezgin Sophie Brasselet @Gaelle_Recher and Virgile Viasnoff, call for abstract soon !

[Claire Wyart @ClaireWyart]

Update - Motor school following Brain prize @Cajal_Training @bdxneuroschool Apply by **July 22** for in vivo mini projects on neuropixels, behavior in humans, all optical experiments for connectivity mapping in brainstem, test how many command neurons elicit motor actions & more!

[Developmental Cell @Dev_Cell]

Online now: Axonal endoplasmic reticulum tubules control local translation via P180/RRBP1-mediated ribosome interactions https://t.co/c3hpra4LJd

[Ali Max Erturk @erturklab]

Very excited to share that our DELiVR method is now open access published @NatureMethods. We created a simple, brain-wide cell analysis deep learning tool, no coding needed! Fiji Plugin makes it accessible to all. https://t.co/qjFk3p5aba
by @Dorie00 @Rami96614090 @moritz_negwer

[Sergio Perez Acebron @Acebron]

Really excited to announce our international #WNT meeting 2024 in Heidelberg (Sept. 25-27). A great opportunity to meet amazing colleagues, discuss outstanding science, and think about the future of the field. Organised by @sfb1324 Please register here: https://t.co/9SEGPCTwV8