gmt999

MD, Drug Development, Biotech investor

[gmt999 @gmt9992]

@DrSamuelBHume @TTRAmyloid Guess they were co- authors and $MRNA employees

[gmt999 @gmt9992]

Incredible strong data presented today at #ESMO2026. Why is there so little discussion on X? Much more impactful and practice changing than the $MRNA melanoma data presented today as well…

[NEJM @NEJM]

Presented at #ESMO26:

In a prespecified interim analysis of a phase 3 trial involving patients with extensive-stage SCLC, the median overall survival was 21.1 months with tarlatamab–durvalumab maintenance therapy and 12.7 months with durvalumab alone. Full DeLLphi-305 trial results: https://t.co/9dEqH6apj2

@myESMO

[gmt999 @gmt9992]

I think the $AMGN Imdelltra data in SCLC presented today are far more exciting than these $MRNA melanoma results

[Sam Fazeli @SamFazeli8]

Congratulations to $AMGN $AZN for a standing ovation :-) practice changing data

[gmt999 @gmt9992]

@CloisterRes @adamfeuerstein @Biohazard3737 This kind of data will make safety departments of FDA and EMEA very nervous

[gmt999 @gmt9992]

@Pharma_Pro @Biohazard3737 Only very few pts have reached the FU of 30 months, so that analysis at this time point is meaningless

[gmt999 @gmt9992]

@GeeDGee @adamfeuerstein Data is already out

[gmt999 @gmt9992]

@bradloncar Great interview Brad!

[gmt999 @gmt9992]

@Biohazard3737 Do algos sleep too?

[gmt999 @gmt9992]

@johndoe16637903 @MartinShkreli How would you look like if you were down 21% since July?

[gmt999 @gmt9992]

@pawcio2009 No-brainer actually…

[gmt999 @gmt9992]

@pawcio2009 Have you heard about them before?

[gmt999 @gmt9992]

@CloisterRes No, she has good genes

[gmt999 @gmt9992]

@semodough This study was funded by $BBIO and one of the authors is a $BBIO employee..

[gmt999 @gmt9992]

@PersimmonTI This study was funded by $BBIO and one of the authors is a $BBIO employee..

[gmt999 @gmt9992]

@MartinShkreli Shouldn’t $SPRB be > 500 by now?

[gmt999 @gmt9992]

@JacobPlieth Amgen calls this construct a half-life extended (HLE) BITE, compared to the first generation of Fc-less BITE, which they call “canonical BITEs”

[gmt999 @gmt9992]

@PersimmonTI Interesting indeed

[gmt999 @gmt9992]

@A_May_MD @BrettErmilio Oh, I still remember the Lion CEO Manish Singh…

[gmt999 @gmt9992]

@A_May_MD @hkd_tweets I wished there were more stupid people like this here on X😉

[gmt999 @gmt9992]

@Frank_S_David @RxRegA @adamfeuerstein Very true