Abigail Groff

Scientific director, working on in vitro gametogenesis

[Matt Krisiloff @mattkrisiloff]

We're hiring for a bunch of technical roles at @Conception

This is arguably the most complex research problem in biotech, and the potential for impact is massive

Apply on our website if you're up for the challenge and think you're a fit!

[Lucas Harrington @CRISPR_LuCas]

IVF without injections, the ability for women to safely have children later in life and for cancer survivors to have children.

Highly recommend reading @Conception's update if you want a glimpse into what the future of fertility looks like

[Avi Roy @agingroy]

Women are born with every egg they’ll ever have. The count falls from about a million to roughly 25,000 by 37, and the eggs that remain keep aging. No one can make a new one. That’s the timer on fertility, and why IVF gets harder with age.

@Conception says it just built a way around it. From a blood draw, they grew human eggs inside a tiny ovary also made from stem cells. The eggs have begun meiosis, the special division that halves a cell's 46 chromosomes to 23. That halving is what makes an egg an egg. A world first, they say. It matters because the starting cell is skin or blood, so ovarian age stops setting the limit.

The road here ran through mice. In 2016 Katsuhiko Hayashi's lab turned a mouse skin cell into an egg, then live pups. Humans stalled for years. Mitinori Saitou's team reached the egg's ancestor, but no one could build the follicle an egg ripens in or start meiosis in a dish. Conception says it cleared both.

These eggs only began meiosis. They haven't completed it, nothing's been fertilized, nothing published, no safety data.

If it holds, it reaches cancer survivors, women in early menopause, women who started late, two-dad families. Half the world, at every age. This could be truly revolutionary.

[Matt Krisiloff @mattkrisiloff]

Read more at the link -- we're hiring a ton too.

So so proud of the team at @Conception!!

https://t.co/DXlbPkub2l

[Abigail Groff @groffAF]

Very proud of this team and the work we're doing at Conception!

[Conception @Conception]

Conception’s mission is to turn stem cells into human eggs and redefine fertility.

We have an exciting update - we've generated the first early human egg cells derived from stem cells.

[Abigail Groff @groffAF]

@kaia_mattioli @PierceOgdenJ @CUDenver Congrats Kaia!! Well deserved and so excited for you!!

[Dr. Kaia Mattioli @kaia_mattioli]

super excited to share that I'm starting as an Assistant Professor at @CUDenver this fall! my lab will be right in downtown Denver :)

https://t.co/tnVeWuUqAd

i'm hiring! if you're interested in joining us to study how alternative isoforms contribute to cancer, please reach out

[Abigail Groff @groffAF]

Open source easy-start cloud compute infrastructure for bio. Looking for testers— if you’re a small start up or lab that could use compute infrastructure support, please reach out!
https://t.co/6QonBUVJBt

[Abigail Groff @groffAF]

@kaia_mattioli Woah!! Wild and I’m glad you’re alright!! What a journey!

[Sager Gosai @SagerGosai]

I’m thrilled to share that our paper “Machine-guided design of cell-type-targeting cis-regulatory elements” was published online in @Nature. https://t.co/NJiCihH745 #genomics #MachineLearning #SyntheticBiology #bioengineering 1/9

[Schuh Lab @SchuhLab]

Women lose >90% of their #eggs by their mid-30s, with persistent #DNADamage driving this loss. But why isn’t this damage repaired?

Our new work in @CurrentBiology, led by @ninadini_sharma, reveals the causes of high DNA damage in aged oocytes.🧬💥

https://t.co/hd8iT1TKnJ (1/13)

[Mercy Nyamewaa Asiedu, Ph.D @dr_nyamewaa]

Check out our blog post on developing deep learning models to predict fetal well-being during labor, using an open source dataset of time series signals consisting of fetal heart rate and uterine contractions and patient clinical data.

[Schmidt Science Fellows @SchmidtFellows]

Fantastic work from the @AppelGroup including Schmidt Science Fellow @AndreadAquino7 Incredible innovation on such a critical issue

[Abigail Groff @groffAF]

@marta_mele_m @mele_lab @BSC_CNS @Bioinfo4women Congrats Marta!!!

[Rahul Satija @satijalab]

Want to hear about the latest updates/new techniques in single cell and spatial genomics? Check out my lab's eighth annual Single Cell Genomics Day on March 29. Keynotes from @IdoAmitLab @JD_Buenrostro and Xiaowei Zhuang. Please RT/spread the word! https://t.co/zG98gkckMU

[James Lee @Dr_James_Lee]

New 2-year postdoc position available in my lab @TheCrick to test novel therapies for #IBD and related diseases by targeting a master regulator of #macrophage-driven inflammation using antibody-drug conjugates and related tools. Apply here: https://t.co/RXAUM2x7JQ Pls retweet!

[Abigail Groff @groffAF]

@ezgi_hsuleyman @UFScripps @darnelr Congrats Ezgi!!! 💃🏼💃🏼

[Alan Penzias @AlanPenzias]

On Tuesday November 8th - Vote! ⁦@docs4fertility⁩ #RoeRoeRoeYourVote #reproductiverights

[Sara Kemppainen @sarakemppainen]

We're building a growing list of all the amazing labs working on female reproductive health.

BUT we know there are some hidden gems. Can you help us find them? 💎👩‍🔬

https://t.co/UA6h59m0xv

[David Ubilava @DavidUbilava]

The wordcloud of names of the authors of the published articles in top-5 journals between 2005 and 2020.