Harry Wu

PhD Candidate at Jun Lab | @ucsf Chemical Biology | @hunter_college Chemistry | Daydreaming about molecules

[UC San Francisco @UCSF]

More than a decade of NIH-funded work from the lab of UCSF's Kevan Shokat led up to this breakthrough. He found a way to create drugs against a mutation that appears in 20% of all cancers, including pancreatic, colon, and lung.

[Harry Wu @harrychembio]

And therapeutically, is there an advantage to adding tall receptors versus the above? Also worth comparing with the approach of degrading the glycocalyx, as recently demonstrated by Bertozzi and Paszek labs.

[Harry Wu @harrychembio]

This is a cool addition to the size-dependent segregation model of immunoreceptor activation! Tall receptors, if at relatively low affinities/densities, can speed up short receptor binding at crowded cell-cell interfaces filled with bulky bystander proteins.

[Fletcher Lab @FletcherLab_UCB]

Preprint out! Cell surfaces are crowded with tall proteins that block immune recognition.

We discovered tall binding proteins create “stepping stones” that help short receptors engage, even in dense crowds.

In memory of Phillip L. Geissler

https://t.co/XS3yKP1n7u

[Harry Wu @harrychembio]

Some thoughts: would simply increasing the affinity/density of the short immunoreceptors also confer a similar kinetic enhancement to that of adding tall receptors?

[Cell @CellCellPress]

Now online! HLA export by melanoma cells decoys cytotoxic T cells to promote immune evasion https://t.co/Qlj3FUedwz

[nature @Nature]

Nature research paper: Inhibitory PD-1 axis maintains high-avidity stem-like CD8+ T cells

https://t.co/6cCvtdlHeZ

[Zhi lindsey Lin @Zhi_Lindsey_Lin]

Excited to share our newest paper on @nchembio where we present temporal MultiMap for dynamic neighborhood mapping. Our sincere gratitude to all our collaborators @WayneNgo1 , Yu-Ting, @harrychembio , @katherine_susa for their hard work!
https://t.co/6Ih01vb7U7

[Harry Wu @harrychembio]

@iskander Do you think the pneumonia/influenza vaccine comparisons were useful? And what are your thoughts on the mice model data? Would’ve been nice to have an additional control of LNPs without mRNA to parse out their relative adjuvant effects

[Vincent Graziano @VinnieViruses]

Hi everybody! I am super excited to share the work done during my PhD published in @nature today! We describe a new mechanism of self- vs. non-self RNA discrimination by showing how N-glycans shield glycoRNAs from stimulating endosomal RNA sensors https://t.co/7hzGDPjvMU

[Katie Galloway @GallowayLabMIT]

So you want to change transgene expression: just change your promoter, right? Changing the promoter increases RNA and thus protein levels. What more could be happening?

[1/n] Well, promoters don’t just set RNA levels; they uniquely transform how RNAs are transmitted into protein levels. 🧵

[Harry Wu @harrychembio]

@Zhi_Lindsey_Lin @ScienceMagazine @realJimWells Congrats Lindsey! Excited to see a more accessible and probe-agnostic photocatalyst for proximity labeling

[Andrew York @AndrewGYork]

Meet MagLOV: an engineered protein that responds STRONGLY to magnetic fields.

This is a fluorescence timelapse of MagLOV in E. coli. We're waving a (small) magnet under the plate.

Can you tell where the magnet is?

Want some? It's on Addgene now! https://t.co/eWs0aAIT1A

[Xiao Wang @WangXiaoLab]

Why can RNA only be linear or circular? It can be branched! We made multi-tailed mRNA, and we had fun! Here is our story led by brilliant graduate student @HongyuChenChem: https://t.co/IkMLUN0wX9 and his cartoon illustration👇@ChemistryMIT @broadinstitute

[Michael Dustin @MichaelLDustin]

Structural evidence for a resting state of the T cell receptor in lipid bilayers. Are prior structures in detergent micelles activated?
The resting state of the human T-cell receptor https://t.co/hASmYLW1OF

[William Gibson @wgibson]

What if small molecules could allow you to alter protein localization at will?

What if they could allow you to turn on specific transcription factors?

Our new manuscript reveals bifunctional molecules to do just that. 🧵

[Kamyar Yazdani @kamyaryzd]

First year of grad school all done! Excited to pass the squeaker and juvenile phases and become pigs of the sounder! @doc_jlmeier @JeffsChemBio @harrychembio @DavidByunCCB @UCSF #chembio

[Kamyar Yazdani @kamyaryzd]

Had a wonderful day at Chemical Biology in the Bay Area conference at Berkeley! Amazing talks from @davidrliu on gene editing and @CarolynBertozzi on bioorthogonal chemistry! Special thanks to great speakers and organizers @UCB_Chemistry!

[Feng Zhang @zhangf]

Delivery of therapeutic molecules is a major bottleneck for treating a wide range of diseases. Today we describe a new modality for delivering proteins based on an engineered contractile injection system @nature https://t.co/eIAn8MW6jN

[ChemBioChem @ChemBioChem]

Scientific Fluency as the Greatest Strength of Chemical Biologists (Prescott, Huang) @PrescottNico @HsinCheHuang @TPCB_NYC https://t.co/tj5yhbvj4A

[That Chemist @That_Chemist]

I have been long-awaiting a TOC graphic as legendary as this.