Top Tweets for #AlloSCT
🔥 Steroid definitions in GVHD (post-SCT) – must know numbers 👇
1️⃣ Steroid-Refractory GVHD (SR-GVHD)
❗ No improvement after 3–5 days of methylpred 2 mg/kg/day
❗ OR progression after >48–72 hrs on steroids
#GVHD #BMT #AlloSCT #Hematology #Transplant #MedEd #FOAMed
2️⃣ Steroid-Resistant GVHD
❗ GVHD progresses despite adequate steroids
❗ OR new organ involvement while on steroids
#GVHD #BMT #AlloSCT #CAR_T #Heme #Immunology #MedEd #FOAMed
3️⃣ Steroid-Dependent GVHD (SD-GVHD)
❗ Symptoms flare during taper below 0.25–0.5 mg/kg/day
❗ OR cannot taper without recurrence within <14 days
#GVHD #AlloSCT #BMT #Immunosuppression #Transplant #Heme #MedEd #FOAMed
4️⃣ Steroid-Intolerant GVHD
❗ Cannot continue steroids due to toxicity (infection, diabetes, psychosis, GI bleed, myopathy)
#GVHD #BMT #AlloSCT #Hematology #GVHDManagement #MedEd #FOAMed ✅
Frontline Allo-SCT in adult ALL at MD Anderson 2025
🔹 High-risk cytogenetics (e.g. KMT2A, complex karyotype)
🔹 Ph-like ALL (CRLF2, JAK2)
🔹 High-risk Ph+ (IZKF1⁺)
🔹 T-ALL: ETP subtype
🔹 Persistent MRD by NGS
#ALL #AlloSCT #Hematology #MDAnderson
10.1001/jamaoncol.2025.0613
🧬 Allo-SCT in Mantle Cell Lymphoma
• Consider in primary chemorefractory or very high-risk cases
• 2-yr OS: 80% (TP53 WT) vs 70% (TP53 altered)
• May overcome TP53 poor prognosis
⚠️ High NRM, select fit patients
#MCL #AlloSCT #TP53 #Hematology #ILC7
Just published our data on the population of patients where the scope of improvement is huge!!!!
Lots of work to do
Thank you to our patients and collaborators
#CML
#AlloSCT
@Reema_Shayra
@SujayRainchwar
@dbhurani
12-year single-centre data on Allo-SCT in CML-BP is out!
2-yr OS: 48.3% | Relapse: 48.5%
Only OS predictor? Post-transplant TKI (p = 0.001)
Takeaway: Transplant early. Maintain well. Pray BP behaves.
#ClinicalResearch_Cafe #CML #ASCT @Rohanhematdoc @dbhurani @SujayRainchwar
Stop by at our EHA2024 poster on relapsed/refractory AML - @zucenka
#AlloSCT #Cancer #EHA2024 #OncoDaily #Oncology #TargetedTherapy #TP53m
https://t.co/Bvz0pV1SFe
Are you a pharmacist or health care professional who manages patients undergoing allogeneic stem cell transplant? Join our next Pharmacy SIG journal club on June 5 at 2 p.m. CT: https://t.co/x3zHMkGg70 #alloSCT
Out in #Cancer by @jayastuMD & @TapKadia ➡️ promosing outcomes in older patients with #AML treated with Cladribine, low-dose cytarabine & venetoclax followed by #AlloSCT @MDAndersonNews #leusm @OncoAlert
➡️ Check out our latest paper:
- >60 y/o👴🏽pts with AML who had AlloSCT after Clad/LDAC/Ven alt with HMA-Ven (Clinical trial @TapKadia) had promsing survival outcomes✅️
- Superior RFS, lower CIR than >60 y/o pts👵🏻who had SCT after Int Rx
@MDAndersonNews
https://t.co/TRB1TG4Raa
Are you a pharmacist or health care professional who manages patients undergoing allogeneic stem cell transplant? Join our next Pharmacy SIG journal club on June 5 at 2 p.m. CT: https://t.co/x3zHMkGg70 #alloSCT
Researchers at the University of Birmingham have explored dynamics of inflammatory biomarkers following #alloSCT. This study seeks to enhance early prediction of patient outcomes by monitoring of 92 proteins after transplantation. Read more on Nucleus: https://t.co/wA25HE8p2a
#AlloSCT the best second shot in T-cell lymphomas, very nice talk by Dr. Schmitz in the #LymphomaWorkingPartySession @TheEBMT @valerotmo
Are you a pharmacist or health care professional who manages patients undergoing allogeneic stem cell transplants #alloSCT or #CARTcells therapy? Join our Pharmacy SIG journal club this afternoon at 2 PM CT: https://t.co/wgw2PKx6vt
Are you a pharmacist or health care professional who manages patients undergoing allogeneic stem cell transplants #alloSCT or #CARTcells therapy? Join our next Pharmacy SIG journal club on Nov. 29 at 2 PM CT: https://t.co/p0SAxGpryi
✅️How to treat mixed chimerism in hemoglobinopathy,
👌a fantastic and helpful algorithm by Josu de la Fuente
#hemoglobinopathy #sickle #allosct #transplantation
New manuscript from our big-team! Reduced Incidence of Neurologic Complications after #alloSCT with Calcineurin-Free GVHD Prophylaxis. By @aitana_balag. @HematoLaFe @GETH_info @sehh_es @IISLaFe @HospitalLaFe https://t.co/ALFVcCCRX6
@MichonneauDavid on operational tolerance after #AlloSCT
Of course we need GvT/GvL (here called hematopoietic GvH) without #GvHD
Very interesting slide
Mittlerweile in Isolation in der Einliegerwohnung und telefonischen Kontakt „nach oben“ zu meiner Mutter. Die weinte kurz, da sie Angst hat, sich angesteckt zu haben. Wir saßen ja gestern Abend noch gemütlich auf dem Sofa. Sie hat zwar AKs nach der #alloSCT bekommen und 5/x
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