Top Tweets for #CAPItello
Tragedia questa mattina a Capitello, dove un imprenditore 72enne di Montesano sulla Marcellana è deceduto in spiaggia dopo un malore. I soccorsi sono stati inutili.
👉 Approfondisci la notizia sul nostro sito o scarica l'app Liratv Play. Link in bio
#Capitello #Cronaca #tragedia
Il Capitello di Calle Campanile Duomo a #Chioggia (VE)���
Madonna di Lourdes 💙
💬 Datato agli anni Ottanta del secolo scorso
🛐 La statuetta è posta all'interno di una nicchia che vuole ricordare una grotta
Capitelli votivi (2017)
#Capitello #artepopolare #Venezia #veneto
PTEN-deficient mHSPC is no longer just a poor-prognosis label.
#ASCO #GU26 #CAPItello-281
It may be a targetable biology.
@OncoAlert @ASCO
🔬 Capivasertib + abiraterone vs abiraterone:
📈 rPFS: 33.2 vs 25.7 months
HR 0.81 (95% CI 0.66–0.98) | p=0.034
Biomarker-selected benefit.
🧬 Why PTEN matters?
Loss of PTEN → PI3K/AKT pathway activation
→ AR-independent survival signaling
→ Therapeutic vulnerability.
This is biologic precision, not escalation for everyone.
📊 What about QoL?
✔ No clinically meaningful deterioration in FACT-P total score
✔ Physical wellbeing decline slightly earlier (expected with AKT AEs)
✔ Overall HRQoL preserved
✔ >80% continued treatment
Targeted therapy without sacrificing function.
⚠ Common AEs (class-consistent):
• Diarrhea
• Rash
• Hyperglycemia
Mostly early. Mostly manageable.
Dose modifications worked.
💡 My clinical take:
We are entering an era where:
mHSPC ≠ one disease
PTEN-deficient ≠ standard ARPI alone
The question is no longer:
“Doublet or triplet?”
It is:
“Who needs pathway-specific targeting?”
Capivasertib + abi may represent the first biomarker-driven strategy in mHSPC.
That’s a paradigm shift.
@DrGeorgeDuke
@KarimFizazi
@urotoday @ecancer
@MedicalwatchHQ @ecancer_espanol
💫🌟 #CAPItello-290 (Phase III) | Annals of Oncology
#Capivasertib + paclitaxel as 1L treatment for metastatic #TNBC
🔸 Dual primary endpoint NOT met
– No OS benefit in the overall population
– No OS benefit in PIK3CA/AKT1/PTEN-altered tumors
🔸 PFS numerically favored capivasertib–paclitaxel
– Overall population: HR 0.72 (95% CI 0.61–0.84)
– Altered tumors: HR 0.70 (95% CI 0.52–0.95)
🔸 ORR numerically improved, suggesting biological activity
– Signal strongest in molecularly selected patients.
🔸 Toxicity matters
– Grade ≥3 diarrhea: 12.7% vs 0.7%
– Treatment-related deaths: 4.2%
– Discontinuation due to AEs: 8.5%
🔸 Clinical takeaway
– Activity ≠ practice-changing
– OS remains the benchmark in 1L metastatic TNBC
– Therapeutic index and patient selection are critical
https://t.co/HU3fVCOebv
@Annals_Oncology @myESMO @JavierCortesMD
#TNBC #BreastCancer #TargetedTherapy #AKT #Oncology #ClinicalTrials #MedicalWatch
🏛️✨ Premio “Capitello” 2025 – IX Edizione
Si è appena conclusa, al Museo Archeologico “Francesco #Ribezzo” 🏺 in #PiazzaDuomo a Brindisi, la cerimonia di conferimento del Premio #Capitello 2025 🎖️ promossa da CISL Taranto Brindisi e Adiconsum Taranto Brindisi.
Il riconoscimento della IX edizione è stato conferito a
S.E. Dott. #LuigiCarnevale, #Prefetto di Brindisi 📨
per il suo costante impegno istituzionale a servizio del territorio.
I temi del nostro appuntamento:
🟢 Partecipazione
🟢 Responsabilità
🟢 Legalità
🟢 Prossimità
🟢 Dialogo
🟢 Lavoro
#CISL #USTCISLTarantoBrindisi #USTCISL #TarantoBrindisi #Taranto #Brindisi #PremioCapitello
I had a presentation this week and just wanted to see what AI has to tell about the trial.
So I uploaded to Notebook LLM and asked for Reports.
The result was mind-blowing!!!
#oncology #capitello #capivasertib #medtwitter #notebookLLM #google #AI #Gemini
Congratulations to the research team at Maria Auxiliadora Hospital for their work on the Capitello-281 study #ESMO2025 #CAPITELLO-281 #ProstateCancer
Il Capitello di Calle Donaggio a #Chioggia (VE)
Sacro Cuore di Gesù 💓
⏳Il capitello era già presente nel 1977
🎨Al suo interno è custodita una statuetta in gesso dipinta
#capitello #arte #veneto
FONTE 📚
Capitelli votivi (2017)
P. Mancarella - P. G. Tiozzo Gobetto
Il Capitello di Fondamenta Marangoni 📍
Madonna di Marina 💙
#chioggia #capitello #Madonna #veneto
Chioggia | Capitello | Venezia | arte popolare
FONTE 📚
Capitelli votivi (2017)
P. Mancarella - P. G. Tiozzo Gobetto
Come trattare i torinesi e i cattolici da d e f i c i e n t i https://t.co/bxDz7gJ9y5 @pontifex @vaticannews @twitorino @laverita @iltempo @Libero_official #gnosticismo #lucifero #capitello #ingegneriasociale #antipapa #Bergoglio
“Truqap combination (w/abiraterone) in #PTEN -deficient #mCSPC #ProstateCancer demonstrated statistically significant & clinically meaningful improvement in rPFS in #CAPItello-281 Phase III trial”
Look forward to seeing this data & relative toxicity https://t.co/z3xll2uiOw
“Truqap combination (w/abiraterone) in #PTEN -deficient #mCSPC #ProstateCancer demonstrated statistically significant & clinically meaningful improvement in rPFS in #CAPItello-281 Phase III trial”
Look forward to seeing this data & relative toxicity https://t.co/z3xll2uiOw
Eccone un altro https://t.co/AnvIUWWcDe @pontifex @ucscei @marcotosatti #gnosi #spretato #Vezelay #bizzarrie #Giuda #capitello #antipapa #Bergoglio
Quello che stupisce seriamente - e preoccupa - sono i cattolici che credono a queste baggianate https://t.co/TqngqWYN27 @pontifex @ucscei @marcotosatti @aldovalli @avvenire #Vezelay #bizzarrie #storiadellarte #capitello #antipapa #gnosi
🚨 📢 Promising results from #CAPItello-291 trial in HR+/HER2– ABC: Adding #Capivasertib to #Fulvestrant boosts PFS significantly (HR 0.60; p<0.001) with manageable AEs often low grade. Early intervention with medications proves effective.
#MedEd #bcsm
https://t.co/IaDgvRxKEK
The #OncoAlertTopTweet #SABCS23 DAY1⃣
Tweet @OncoAlert 🚨 Faculty @stage4kelly
@MOliveira_MD presents patient reported outcomes (PROs) data of #CAPITELLO-291 trial ➡️ PROs data support the positive benefit/risk ratio of capivasertib in AI resistant HR+/HER2-neg #BreastCancer
Best, @weoncologists
At #SABCS23 @MOliveira_MD presents patient reported outcomes (PROs) data of #CAPITELLO-291 trial
➡️ PROs data support the positive benefit/risk ratio of capivasertib in AI resistant HR+/HER2-neg #breastcancer
@OncoAlert @SABCSSanAntonio
At #SABCS23 @MOliveira_MD presents patient reported outcomes (PROs) data of #CAPITELLO-291 trial
➡️ PROs data support the positive benefit/risk ratio of capivasertib in AI resistant HR+/HER2-neg #breastcancer
@OncoAlert @SABCSSanAntonio
FDA aprueba FOne CDx como DxC para Capivasertib+Fulvestrant en #CancerdeMama metást RH+ HER2-con alt en PIK3CA/AKT1/PTEN a progresión T.Hormonl tras result #CAPITELLO. #SoltiHOPE propicio entrar a muchos pac
@_SOLTI
Approves Capivas+Fulvest The ASCO Post https://t.co/dNTKo4G7ad
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